RESUMO
ABSTRACT A retrospective cohort study, were evaluated: polymyxin B plus aminoglycosides or polymyxin B plus other antibiotics. Any degree of acute kidney injury occurred in 26 (86.6%) patients. The median time to acute kidney injury was 6.0 (95% CI 3-14) days in the polymyxin-aminoglycoside containing regimen group, against 27.0 (95% CI 6-42) days in the polymyxin with other antimicrobial combinations group (p = 0.03). Polymyxin B with aminoglycosides group progressed faster to any degree of renal dysfunction.
Assuntos
Humanos , Masculino , Feminino , Polimixina B/uso terapêutico , Infecções por Enterobacteriaceae/tratamento farmacológico , Rim/efeitos dos fármacos , Mediastinite/microbiologia , Mediastinite/tratamento farmacológico , Antibacterianos/uso terapêutico , Testes de Sensibilidade Microbiana , Carbapenêmicos/farmacologia , Estudos Retrospectivos , Resultado do Tratamento , Estatísticas não Paramétricas , Medição de Risco , Resistência beta-Lactâmica/efeitos dos fármacos , Infecções por Enterobacteriaceae/mortalidade , Estimativa de Kaplan-Meier , Injúria Renal Aguda/induzido quimicamente , Aminoglicosídeos/uso terapêutico , Mediastinite/mortalidadeRESUMO
A retrospective cohort study, were evaluated: polymyxin B plus aminoglycosides or polymyxin B plus other antibiotics. Any degree of acute kidney injury occurred in 26 (86.6%) patients. The median time to acute kidney injury was 6.0 (95% CI 3-14) days in the polymyxin-aminoglycoside containing regimen group, against 27.0 (95% CI 6-42) days in the polymyxin with other antimicrobial combinations group (p=0.03). Polymyxin B with aminoglycosides group progressed faster to any degree of renal dysfunction.
