Odds ratio of occurrence of pain, postural changes, and disabilities of violinists.

The objective of this study is to evaluate the odds ratio of occurrence of pain, postural changes, and disabilities of violinists. Thirty-eight violinists were assessed. Photographs from anterior, posterior, and lateral views were taken and analyzed using Software of Postural Analysis. Pain was assessed by the Visual Analogue Pain Scale and the musculoskeletal disability of the arm, shoulder, and hand questionnaire (DASH). A logistic regression model was employed and all variables related to posture, age, gender, hours of practice, and duration of practice were considered. The results regarding the VAS and DASH were analyzed using multivariate techniques. The most important variables for the discrimination between the groups regarding the VAS scores were head and shoulder and thoracic kyphosis. For the DASH index, the key variables were the lateral spinal deviation and the head tilt. The odds ratio of occurrence pain was associated with the duration of the practice and the following postural variables: shoulder asymmetries, head postures, and lumbar lordosis. Scapular postures and thoracic kyphosis were associated with hours of practice, and the scapular postures with the duration of practice. This article provides new evidence of occurrence of pain, postural changes and disabilities in violinists. The odds ratio of occurrence pain was associated with the duration of the professional practice.

Comparative evaluation of HPV genotyping: A study on the performance concordance between Anyplex II HPV28 detection and Linear Array genotyping tests in nationwide studies in Brazil.

BACKGROUND: Advances in laboratory techniques for HPV diagnosis necessitate a thorough assessment of the efficiency, replicability, sensitivity, and specificity of those methods. This study aims to validate and compare HPV detection/genotyping using the Anyplex™ II HPV28 Detection assay (Seegene) assay and the Linear Array HPV Genotyping test (Roche Diagnostics) on genital samples for use in epidemiological studies. METHODS: From 6,388 penile and cervical DNA samples collected in the POP-Brazil, 1,745 were randomly selected to be included in this study. The samples were submitted to HPV detection and genotyping following the manufacturers' protocols. DNA was genotyped using the Anyplex™ II HPV28 Detection kit (Seegene), and the results were compared to those obtained using the Linear Array HPV Genotyping test (Roche Diagnostics). Concordance of HPV genotyping results was assessed by the percentage agreement and Cohen's kappa score (κ). RESULTS: The agreement between the two methodologies was deemed good for HPV detection (κ = 0.78). Notably, Anyplex™ II HPV28 demonstrated enhanced capability in detecting a broader spectrum of genotypes compared to Linear Array. CONCLUSION: Anyplex™ II HPV28 exhibited comparable results to the Linear Array assay in clinical specimens, showcasing its potential suitability for a diverse array of research applications requiring the detection and genotyping of HPV. The study supports the utility of Anyplex™ II HPV28 as an effective tool for HPV screening in epidemiological studies, emphasizing its robust performance in comparison to established diagnostic tests.

Can species guilds act as hubs for energy transfer in macrophyte meadows of Amazonian floodplain lakes?

Aquatic macrophytes are the main autochthonous component of primary production in the Amazon Basin. Floating meadows of these plants support habitats with highly diverse animal communities. Fishes inhabiting these habitats have been assumed to use a broad range of food items and compose a particular food web. We employed carbon (δ13C) and nitrogen (δ15N) stable isotope analysis to draw the trophic structure of these habitats and to trace the energy flow by its trophic levels. Fishes and other animals from 18 independent macrophyte meadows of a floodplain lake of the Solimões River (Amazonia, Brazil) were analyzed. The food web of macrophyte meadows consists of four trophic levels above autotrophic sources. In general, primary consumers exhibited a broader range of food sources than the upper trophic levels. Some fish species depended on a large number of food sources and at the same time are consumed by several predators. The energy transfer from one trophic level to the next was then mainly accomplished by these species concentrating a high-energy flux and acting as hubs in the food web. The broad range of δ13C values observed indicates that the organisms living in the macrophyte meadows utilize a great diversity of autotrophic sources.

FIRST REPORT OF CHEMICAL IMMOBILIZATION AND PHYSIOLOGICAL PARAMETERS FOR FREE-RANGING MANED SLOTH (BRADYPUS TORQUATUS), USING A COMBINATION OF KETAMINE AND MEDETOMIDINE.

The maned sloth (Bradypus torquatus) is an endemic and endangered species of two Brazilian states, with much unknown biological information needed to direct conservation actions. Other sloth species have been studied regarding anesthesia; however, there is a lack of anesthesia research for the maned sloth. Anesthetic data were collected from 12 free-range maned sloths that were immobilized for a field examination. Individuals were anesthetized using a combination of ketamine (4.0 mg/kg) and medetomidine (0.03 mg/kg), and antagonized with atipamezole (0.1 mg/kg). Time to induction and recovery were recorded and compared with sex and age classes. After the induction and until antagonist administration, physiological parameters (rectal temperature, heart rate, respiratory rate, and oxygen saturation) were recorded every 10 min during anesthesia and were statistically evaluated over time. Induction was fast (3.21 ± 0.76), but recovery was longer (113.3 ± 18) when compared to other studies. Induction and recovery times were not different across sex or age classes. Rectal temperature, heart rate, and oxygen saturation remained stable throughout the procedure. Respiratory rate significantly decreased over time, from 18.25 ± 7.03 to 13.17 ± 3.66 movements per minute. Our results indicate that the described combination of ketamine and medetomidine is a safe and effective choice for anesthesia of maned sloths.

Perceived quality of life and associated factors in long COVID syndrome among older Brazilians: A cross-sectional study.

AIMS AND OBJECTIVES: This paper aims to: (a) determine the personal, sociodemographic, clinical, behavioural, and social characteristics of older Brazilians with clinical evidence of long COVID; (b) evaluate perceived quality of life and determine its association with personal, sociodemographic, behavioural, clinical and social variables; and (c) assess significant predictors of high perceived QoL. BACKGROUND: Given the inherent vulnerabilities of the ageing process, the older people are an at-risk group for both contagion of SARS-CoV-2 and the perpetuation of residual symptoms after infection, the so-called long COVID or post-COVID syndrome. DESIGN: A cross-sectional survey design using the STROBE checklist. METHODS: Brazilian older people with long COVID syndrome (n = 403) completed a phone survey measuring personal, sociodemographic, behavioural, clinical, and social characteristics, and perceived Quality of Life (QoL). Data were collected from June 2021-March 2022. A multiple linear regression model was performed to identify salient variables associated with high perceived QoL. RESULTS: The mean age of participants was 67.7 ± 6.6 years old. The results of the multivariate regression model showed that race, home ownership, daily screen time, musculoskeletal and anxiety symptoms, and work situation were the significant predictors of QoL among COVID-19 survivors. CONCLUSIONS: Knowledge about the persistence of physical, emotional, and social symptoms of COVID-19 can help nurses and other healthcare providers to improve the management of survivors, bringing benefits to the whole society. RELEVANCE TO CLINICAL PRACTICE: Given the novelty of long-COVID and its heterogeneous trajectory, interventions focusing on the repercussions and requirements unique to more vulnerable older persons should be developed and these aspects should be included in public health recommendations and policymakers' concerns. PATIENT OR PUBLIC CONTRIBUTION: No patient or public contribution was required to design, to outcome measures or undertake this research. Patients/members of the public contributed only to the data collection.

Guia para a elaboração de relatórios fonoaudiológicos de crianças implantadas: opinião de especialistas / Guide to the preparation of speech reports for implanted children: opinion of specialists

RESUMO Objetivo Desenvolver guia para elaboração de relatórios fonoaudiológicos de crianças implantadas para serem compartilhados entre fonoaudiólogos dos serviços de implante coclear (IC) e reabilitadores. Método O método Delphi foi utilizado para selecionar os itens relevantes e fundamentais que deveriam constar nas duas versões propostas para compor o guia: Guia 1 - Relatórios fonoaudiológicos fornecidos pelo serviço de IC aos reabilitadores, e Guia 2 - Relatórios fonoaudiológicos fornecidos pelos reabilitadores aos serviços de IC. Vinte e um fonoaudiólogos especialistas e com experiência na área de implante coclear e de reabilitação auditiva participaram da discussão e do julgamento dos itens durante as rodadas de seleção. Considerou-se consenso quando o item obteve a concordância igual ou superior a 80% entre os participantes, sendo selecionados para comporem os dois guias. Resultados Após as duas rodadas, 21 itens do Guia 1 obtiveram consenso entre os terapeutas, ou seja, mais de 80% deles concordaram que estes itens deveriam estar presentes no relatório enviado pelo serviço de IC. Para o Guia 2, 22 itens analisados pelos fonoaudiólogos atuantes em serviços de IC setor pós-operatório, foram selecionados na segunda rodada. Conclusão A partir da análise das duas rodadas, foi desenvolvido o "Guia para a elaboração de relatórios fonoaudiológicos: intersecção entre serviço de IC e reabilitadores". Este material pode ser aplicado na rotina de acompanhamento de crianças implantadas, padronizando as informações compartilhadas sobre o dispositivo eletrônico, resultados de avaliações, monitoramento dos resultados e processo terapêutico dessa população.

ABSTRACT Purpose To develop a guide for the preparation of speech-language reports of implanted children to be shared among speech-language pathologists of cochlear implant (CI) services and rehabilitation professionals. Methods The Delphi method was used to select the relevant and fundamental items that should be included in the two versions proposed for the guide: Guide 1 - Speech-language reports provided by the CI services to rehabilitators, and Guide 2 - Speech-language reports provided by the rehabilitators to CI services. Twenty-one speech therapists specialized and with experience in cochlear implants and auditory rehabilitation participated in the discussion and judgment of the items during the selection rounds. Consensus was considered when the item reached agreement equal to or greater than 80% among participants, being selected to compose the two guides. Results After the two rounds, 21 items from Guide 1 reached consensus among therapists, that is, more than 80% of them agreed that these items should be present in the report sent by the CI service. For Guide 2, 22 items analyzed by speech therapists working in CI services in the postoperative sector were selected in the second round. Conclusion Based on the analysis of the two rounds, the "Guide for the preparation of speech-language pathology reports: intersection between CI service and rehabilitators" was developed. This material can be applied in the follow-up of implanted children, standardizing the information shared about the electronic device, evaluation results, monitoring of results and therapeutic process of this population.

Guide to the preparation of speech reports for implanted children: opinion of specialists. / Guia para a elaboração de relatórios fonoaudiológicos de crianças implantadas: opinião de especialistas.

PURPOSE: To develop a guide for the preparation of speech-language reports of implanted children to be shared among speech-language pathologists of cochlear implant (CI) services and rehabilitation professionals. METHODS: The Delphi method was used to select the relevant and fundamental items that should be included in the two versions proposed for the guide: Guide 1 - Speech-language reports provided by the CI services to rehabilitators, and Guide 2 - Speech-language reports provided by the rehabilitators to CI services. Twenty-one speech therapists specialized and with experience in cochlear implants and auditory rehabilitation participated in the discussion and judgment of the items during the selection rounds. Consensus was considered when the item reached agreement equal to or greater than 80% among participants, being selected to compose the two guides. RESULTS: After the two rounds, 21 items from Guide 1 reached consensus among therapists, that is, more than 80% of them agreed that these items should be present in the report sent by the CI service. For Guide 2, 22 items analyzed by speech therapists working in CI services in the postoperative sector were selected in the second round. CONCLUSION: Based on the analysis of the two rounds, the "Guide for the preparation of speech-language pathology reports: intersection between CI service and rehabilitators" was developed. This material can be applied in the follow-up of implanted children, standardizing the information shared about the electronic device, evaluation results, monitoring of results and therapeutic process of this population.

OBJETIVO: Desenvolver guia para elaboração de relatórios fonoaudiológicos de crianças implantadas para serem compartilhados entre fonoaudiólogos dos serviços de implante coclear (IC) e reabilitadores. MÉTODO: O método Delphi foi utilizado para selecionar os itens relevantes e fundamentais que deveriam constar nas duas versões propostas para compor o guia: Guia 1 - Relatórios fonoaudiológicos fornecidos pelo serviço de IC aos reabilitadores, e Guia 2 - Relatórios fonoaudiológicos fornecidos pelos reabilitadores aos serviços de IC. Vinte e um fonoaudiólogos especialistas e com experiência na área de implante coclear e de reabilitação auditiva participaram da discussão e do julgamento dos itens durante as rodadas de seleção. Considerou-se consenso quando o item obteve a concordância igual ou superior a 80% entre os participantes, sendo selecionados para comporem os dois guias. RESULTADOS: Após as duas rodadas, 21 itens do Guia 1 obtiveram consenso entre os terapeutas, ou seja, mais de 80% deles concordaram que estes itens deveriam estar presentes no relatório enviado pelo serviço de IC. Para o Guia 2, 22 itens analisados pelos fonoaudiólogos atuantes em serviços de IC setor pós-operatório, foram selecionados na segunda rodada. CONCLUSÃO: A partir da análise das duas rodadas, foi desenvolvido o "Guia para a elaboração de relatórios fonoaudiológicos: intersecção entre serviço de IC e reabilitadores". Este material pode ser aplicado na rotina de acompanhamento de crianças implantadas, padronizando as informações compartilhadas sobre o dispositivo eletrônico, resultados de avaliações, monitoramento dos resultados e processo terapêutico dessa população.

Elaboração de um protocolo de classificação de risco para pacientes oncológicos em Cuidados Paliativos Domiciliares / Development of a risk classification protocol for cancer patients in Home-based Palliative Care

RESUMO Os serviços de Cuidados Paliativos Domiciliares especializados no tratamento de pacientes oncológicos têm como objetivo identificar e controlar sintomas físicos, psicossociais e espirituais em domicílio. Alguns desafios encontrados são a complexidade de sintomas, a sobrevida reduzida dos pacientes com câncer avançado e limitações do sistema de saúde. Para estratificar a prioridade de atendimento dos pacientes com câncer avançado em Cuidados Paliativos Domiciliares, foi elaborado um protocolo de classificação de risco. Este artigo é um relato de experiência sobre o processo de elaboração de um protocolo de classificação de risco para pacientes com câncer avançado atendidos em um serviço de Cuidados Paliativos Domiciliares no Rio de Janeiro. A etapa inicial envolveu reuniões da equipe da Assistência Domiciliar de um hospital oncológico e buscas estruturadas na literatura. Depois, foram listadas as situações clínicas de manejo mais complexo no domicílio, chamadas de sinais e sintomas de alerta: dor, falta de ar, náuseas/ vômitos, sangramento e confusão mental aguda. Elaborou-se um protocolo de avaliação e classificação de risco com cinco categorias/cores, para determinar a prioridade de atendimento dos pacientes. O sistema de triagem desenvolvido possui fácil aplicabilidade e requer um treinamento breve do profissional de saúde para que possa ser utilizado durante os atendimentos domiciliares.

ABSTRACT Home-based Palliative Care services specialized in the treatment of cancer patients aim to identify and control physical, psychosocial, and spiritual symptoms at home. Some challenges encountered are the complexity of symptoms, reduced survival of patients with advanced cancer, and limitations of the health care system. To stratify the priority of care for patients with advanced cancer in home Palliative Care, a risk classification protocol was developed. This article is an experience report on the process of creating a risk classification protocol for patients with advanced cancer treated at a home Palliative Care service in Rio de Janeiro. The initial stage involved meetings of the home care team at an oncology hospital and structured searches in the literature. Afterwards, the clinical situations of more complex management at home were listed and named as warning signs and symptoms: pain, shortness of breath, nausea/ vomiting, bleeding, and acute mental confusion. An assessment and triage protocol was developed with five categories/colors to determine the priority of patient care. The developed triage system has easy applicability and requires a brief training of the health professional so that it can be used during home visits.

Fatores associados à autopercepção de desempenho acadêmico por estudantes de Odontologia durante a pandemia da COVID-19 / Factores asociados a la autopercepción del desempeño académico de los estudiantes de odontología durante la pandemia de COVID-19 / Factors associated with self-perceived academic performance by dentistry undergraduates during the COVID-19 pandemic

O estudo objetivou investigar associações entre a autopercepção do desempenho acadêmico e crenças de autoeficácia, variáveis sociodemográficas e vida acadêmica em graduandos em Odontologia no período de ensino remoto durante a pandemia de COVID-19. Trata-se de um estudo transversal que empregou os seguintes instrumentos no formato virtual: questões sociodemográficas, autopercepção do rendimento escolar, aprendizagem durante o período de ensino remoto, e Escala de Autoeficácia Geral Percebida (EAGP). Os questionários foram disponibilizados entre setembro de 2020 e abril de 2021 para os alunos matriculados entre o segundo e o quinto ano do curso. Utilizaram-se modelos de regressão para analisar as associações entre variáveis preditores com o desfecho autopercepção do desempenho acadêmico. Estimou-se odds-ratiosbrutos e ajustados com os respectivos intervalos de 95% de confiança. Uma amostra de 150 graduandos respondeu ao questionário, sendo 70,0% mulheres (n=105) com idade média de 21,7 anos. Verificou-se que a autopercepção do desempenho acadêmico classificada como 'insuficiente ou pouco suficiente' esteve associada aos estudantes que não se adaptaram bem à nova experiência de ensino e aprendizagem (OR=8,08; IC95%: 2,02-32,35), que acharam que não dominavam os conhecimentos e competências ensinados nas aulas remotas (OR=10,74; IC95%: 2,81-41,02) e que achavam que o seu desempenho como estudante havia piorado desde que as aulas presenciais foram suspensas (OR=8,19; IC95%: 1,59-42,12). Conclui-se que durante o período pandêmico, a baixa autopercepção do rendimento acadêmico esteve associada à dificuldade de adaptação ao novo modelo de ensino remoto, ao senso de não assimilação dos conteúdos e de piora do desempenho escolar (AU).

El estudio tuvo como objetivo investigar asociaciones entre la autopercepción del desempeño académico y las creencias de autoeficacia, variables sociodemográficas y vida académica en estudiantes de Odontología durante el período de enseñanza remota durantela pandemia de COVID-19. Se trata de un estudio transversal que utilizó los siguientes instrumentos en formato virtual: preguntas sociodemográficas, rendimiento académico autopercibido, aprendizaje durante el periodo de docencia remota y Escala de Autoeficacia General Percibida (EAGP). Los cuestionarios estuvieron disponibles entre septiembre de 2020 y abril de 2021 para estudiantes matriculados entre el segundo y quinto año del curso. Se utilizaron modelos de regresión para analizar las asociaciones entrelas variables predictivas y la autopercepción de resultados del rendimiento académico. Los odds ratios crudos y ajustados se estimaron con sus respectivos intervalos de confianza del 95%. Respondieron al cuestionario una muestra de 150 estudiantes universitarios, de los cuales el 70,0% eran mujeres (n=105) con una edad promedio de 21,7 años. Se encontró que la autopercepción del rendimiento académico clasificado como 'insuficiente o insuficiente' se asoció con estudiantes que no se adaptaron bien a la nueva experiencia de enseñanza y aprendizaje (OR=8,08; IC 95%: 2,02-32,35), quienes sintieron que no dominaban los conocimientos y habilidades impartidos en las clases remotas (OR=10,74; IC 95%: 2,81-41,02) y que sentían que su desempeño como estudiante había empeorado desde que se suspendieron las clases presenciales (OR=8,19; IC 95%: 1,59-42,12). Se concluye que durante el período de pandemia la baja autopercepción del rendimiento académico se asoció con la dificultad de adaptación al nuevo modelo de enseñanza a distancia, la sensación de no asimilación de contenidos y el empeoramiento del rendimiento académico (AU).

This cross-sectional study investigates associations between self-perceived academic performance by dentistry undergraduates and self-efficacy beliefs, sociodemographic variables and academic life during the remote teaching implemented due to the COVID-19 pandemic. Data collected by means of questionnaires (sociodemographic questions, self-perceived academic performance, learning during the remote teaching period) and the General Self-Efficacy Scale (GSE), answered online. The questionnaires were emailed between September 2020 and April 2021 to students enrolled between the second and fifth year. Associations between predictor variables and the outcome (self-perceived academic performance) were analyzed by regression models. Crude and adjusted odds-ratios were estimated with their respective 95% confidence intervals. A total of 150 undergraduates answered the questionnaires of which, 70.0% were women (n=105) with mean age of 21.7 years. Self-perceived academic performance classified as 'insufficient or insufficient' was associated with students who did not adapt well to the new teaching-learning experience (OR=8.08; 95%CI: 2.02­32.35), who felt that they lacked mastery of the knowledge and skills taught in remote classes (OR=10.74; 95%CI: 2.81­41.02) and who felt that their academic performance had worsened since in-class lessons were suspended (OR=8.19; 95%CI: 1.59­42.12). During the pandemic, low self-perceived academic performance was associated with difficulties in adapting to the new remote teaching model, a sense of non-assimilation of content and worsened academic performance (AU).

Integrated Metabolic and Inflammatory Signatures Associated with Severity of, Fatality of, and Recovery from COVID-19.

Severe manifestations of coronavirus disease 2019 (COVID-19) and mortality have been associated with physiological alterations that provide insights into the pathogenesis of the disease. Moreover, factors that drive recovery from COVID-19 can be explored to identify correlates of protection. The cellular metabolism represents a potential target to improve survival upon severe disease, but the associations between the metabolism and the inflammatory response during COVID-19 are not well defined. We analyzed blood laboratorial parameters, cytokines, and metabolomes of 150 individuals with mild to severe disease, of which 33 progressed to a fatal outcome. A subset of 20 individuals was followed up after hospital discharge and recovery from acute disease. We used hierarchical community networks to integrate metabolomics profiles with cytokines and markers of inflammation, coagulation, and tissue damage. Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) promotes significant alterations in the plasma metabolome, whose activity varies according to disease severity and correlates with oxygen saturation. Differential metabolism underlying death was marked by amino acids and related metabolites, such as glutamate, glutamyl-glutamate, and oxoproline, and lipids, including progesterone, phosphocholine, and lysophosphatidylcholines (lysoPCs). Individuals who recovered from severe disease displayed persistent alterations enriched for metabolism of purines and phosphatidylinositol phosphate and glycolysis. Recovery of mild disease was associated with vitamin E metabolism. Data integration shows that the metabolic response is a hub connecting other biological features during disease and recovery. Infection by SARS-CoV-2 induces concerted activity of metabolic and inflammatory responses that depend on disease severity and collectively predict clinical outcomes of COVID-19. IMPORTANCE COVID-19 is characterized by diverse clinical outcomes that include asymptomatic to mild manifestations or severe disease and death. Infection by SARS-CoV-2 activates inflammatory and metabolic responses that drive protection or pathology. How inflammation and metabolism communicate during COVID-19 is not well defined. We used high-resolution mass spectrometry to investigate small biochemical compounds (<1,500 Da) in plasma of individuals with COVID-19 and controls. Age, sex, and comorbidities have a profound effect on the plasma metabolites of individuals with COVID-19, but we identified significant activity of pathways and metabolites related to amino acids, lipids, nucleotides, and vitamins determined by disease severity, survival outcome, and recovery. Furthermore, we identified metabolites associated with acute-phase proteins and coagulation factors, which collectively identify individuals with severe disease or individuals who died of severe COVID-19. Our study suggests that manipulating specific metabolic pathways can be explored to prevent hyperinflammation, organ dysfunction, and death.

Fatores associados à visita à emergência ou hospitalização em cuidados paliativos oncológicos domiciliares: uma revisão integrativa / Factors associated with emergency room visit or hospitalization in care oncolagy home care: an integrative review / Factores asociados a la visita a urgencias o a la hospitalización en cuidado atención oncológica a domicilio: una revisión integradora

Objetivo: identificar os fatores associados à visita à emergência ou hospitalização dos pacientes oncológicos em cuidados paliativos domiciliares. Método: revisão integrativa nas bases PubMed, LILACS, Web of Science e Embase. Perguntou-se "quais os fatores associados à visita a serviços de emergência ou hospitalização de pacientes oncológicos em cuidados paliativos domiciliares?". Descritores foram neoplasias; cuidados paliativos; hospitalização; serviços médicos de emergência; serviços de assistência domiciliar. Critérios de elegibilidade foram texto na íntegra; entre 2012 e 2022; idioma inglês, português ou espanhol; idade adulta. Resultados:foram selecionados 16 artigos. As causas mais comuns de visita à emergência/hospitalização foram dor, falta de ar, infecção, sintomas digestivos, delirium e queda do estado geral/fadiga. Conclusão: este estudo identificou lacunas em que os cuidados paliativos domiciliares podem ser aprimorados.

Objective: to identify the factors associated with the emergency visit or hospitalization of cancer patients in palliative home care. Method: integrative review in PubMed, LILACS, Web of Science and Embase. The question was "what factors are associated with visiting emergency services or hospitalization of cancer patients in palliative home care?". Descriptors were neoplasms; palliative care; hospitalization; emergency medical services; home care services. Eligibility criteria were full text; between 2012 and 2022; English, Portuguese or Spanish language; adulthood. Results: 16 articles were selected. The most common causes of emergency room visits/hospitalization were pain, shortness of breath, infection, digestive symptoms, delirium, and poor general condition/fatigue. Conclusion: this study identified gaps in which palliative home care can be improved.

Objetivo: identificar los factores asociados a la visita a urgencias u hospitalización de pacientes oncológicos en cuidados paliativos domiciliarios. Método: revisión integrativa en PubMed, LILACS, Web of Science y Embase. La pregunta fue "¿qué factores se asocian con la visita a los servicios de emergencia o la hospitalización de pacientes oncológicos en cuidados paliativos domiciliarios?". Descriptores fueron neoplasias; Cuidados paliativos; hospitalización; servicios médicos de emergencia; servicios de atención domiciliaria. Los criterios de elegibilidad fueron texto completo; entre 2012 y 2022; idioma inglés, portugués o español; edad adulta. Resultados:se seleccionaron 16 artículos. Las causas más comunes de visitas a la sala de emergencias/hospitalización fueron dolor, dificultad para respirar, infección, síntomas digestivos, delirio y mal estado general/fatiga. Conclusión: este estudio identificó brechas en las que se pueden mejorar los cuidados paliativos domiciliários.

Lições aprendidas em tempos pandêmicos: revisão de escopo sobre a atuação docente e os impactos na saúde / Lessons learned in pandemic times: scope review on teaching activity and health impacts / Lecciones adquiridas en tiempos pandémicos: examen del ámbito de enseñanza y los efectos en la salud

A pandemia de Covid-19 alterou a atuação dos profissionais da educação para o ensino remoto devido à emergência sanitária de saúde pública global. Esse novo formato de trabalho trouxe consequências e desafios para a educação mundial, e deixou legado a ser incorporado na prática educacional. Este estudo teve como objetivo analisar como a literatura científica nacional e internacional abordou o trabalho docente no período da pandemia de COVID-19, bem como a saúde desses profissionais e as lições aprendidas a partir desse contexto. Realizou-se uma revisão de escopo com abrangência nacional e internacional, no período que compreende os anos de 2020 a 2021. Foram analisados 36 estudos e identificados três temáticas principais: (1) atuação docente e estratégias pedagógicas, (2) impactos na saúde física e mental de docentes e (3) lições educacionais aprendidas. Constatou-se que a experiência do trabalho remoto emergencial, sem diretriz política específica e planejamento para desenvolvimento desta nova forma de desenvolvimento do trabalho docente foi complexa e imprevisível em todos os países componentes do estudo. Nos demais países pesquisados, os dados expressam um resultado semelhante ao brasileiro, com dificuldades no acesso e permanência à internet pelos estudantes e professores, além da ausência de equipamentos apropriados para ministrar/assistir as aulas remotas.

The COVID-19 pandemic has shifted the workings of education professionals to remote education due to the global public health health health emergency. This new format of work brought consequences and challenges for world education, and left a legacy to be incorporated into educational practice. This study aimed to analyse how national and international scientific literature addressed the teaching work in the period of the COVID-19 pandemic, as well as the health of these professionals and the lessons learned from this context. A national and international scoping review has been carried out in the period from 2020 to 2021. 36 studies were analysed and three main themes identified: (1) teaching performance and pedagogical strategies, (2) impacts on the physical and mental health of teachers and (3) educational lessons learned. It was found that the experience of remote emergency work, without specific policy guidelines and planning for the development of this new form of teaching work development, was complex and unpredictable in all the countries that were components of the study. In the other researched countries, the data expresses a result similar to the Brazilian one, with difficulties in access and permanence to the internet by the students and teachers, besides the absence of appropriate equipment for teaching/attending the remote lessons.

La pandemia del Covid-19 ha cambiado las acciones de los profesionales de la educación a distancia debido a la emergencia mundial de salud pública. Este nuevo formato de trabajo ha traído consecuencias y retos para la educación mundial y ha dejado el legado para ser incorporado a la práctica educativa. El objetivo de este estudio fue analizar cómo la literatura científica nacional e internacional abordó el trabajo docente durante el período de pandemia COVID-19, así como la salud de estos profesionales y las lecciones aprendidas de él. En el período 2020-2021 se llevó a cabo un examen del alcance nacional e internacional. Se analizaron 36 estudios y se identificaron tres temas principales: 1) actividades docentes y estrategias pedagógicas, 2) impactos en la salud física y mental de los maestros y 3) lecciones educativas aprendidas. Se constató que la experiencia de la labor de emergencia a distancia, sin directrices normativas y planificación específicas para el desarrollo de esta nueva forma de desarrollo del trabajo docente, era compleja e impredecible en todos los países que elaboraban el estudio. En los otros países investigados, los datos expresan un resultado similar al del brasileño, con dificultades para acceder y permanecer en Internet por parte de estudiantes y profesores, además de la falta de equipamiento adecuado para dar/ver clases remotas.

Monitoring the Establishment of VOC Gamma in Minas Gerais, Brazil: A Retrospective Epidemiological and Genomic Surveillance Study.

Since its first identification in Brazil, the variant of concern (VOC) Gamma has been associated with increased infection and transmission rates, hospitalizations, and deaths. Minas Gerais (MG), the second-largest populated Brazilian state with more than 20 million inhabitants, observed a peak of cases and deaths in March-April 2021. We conducted a surveillance study in 1240 COVID-19-positive samples from 305 municipalities distributed across MG's 28 Regional Health Units (RHU) between 1 March to 27 April 2021. The most common variant was the VOC Gamma (71.2%), followed by the variant of interest (VOI) zeta (12.4%) and VOC alpha (9.6%). Although the predominance of Gamma was found in most of the RHUs, clusters of Zeta and Alpha variants were observed. One Alpha-clustered RHU has a history of high human mobility from countries with Alpha predominance. Other less frequent lineages, such as P.4, P.5, and P.7, were also identified. With our genomic characterization approach, we estimated the introduction of Gamma on 7 January 2021, at RHU Belo Horizonte. Differences in mortality between the Zeta, Gamma and Alpha variants were not observed. We reinforce the importance of vaccination programs to prevent severe cases and deaths during transmission peaks.

Encaminhamento dos usuários com alterações renais ao nefrologista pela Estratégia Saúde da Família: estudo transversal / Referral of users with kidney disorders by the Family Health Strategy to the nephrologist: a cross-sectional study / Derivación de usuarios con trastornos renales al nefrólogo por la Estrategia Salud de la Familia: estudio transversal

Objetivo: analisar os encaminhamentos de usuários de risco ao desenvolvimento da doença renal crônica para serviço especializado de nefrologia pelas equipes da Estratégia de Saúde da Família. Método: estudo transversal, com coleta de dados dos prontuários de usuários diagnosticados com diabetes e hipertensão arterial, acompanhados na atenção primária no município do Rio de Janeiro, em março de 2021. O protocolo de pesquisa obteve a aprovação em Comitê de Ética. Resultados: a solicitação de creatinina sérica foi identificada em 96% dos prontuários, mas tal realidade foi diferente junto aos demais exames. Quanto aos estágios, o mais indicado para encaminhamento foi o 3B compreendendo 37%, seguido pelo estágio 4 que abrange 33% da amostra. Conclusão: sendo uma doença de curso insidioso, o acompanhamento laboratorial deve ser realizado continuamente. É inquestionável o papel da Atenção Primária, porém diante dos desafios evidenciados é importante considerar novas estratégias para melhor efetivação das ações e integralidade do cuidado na rede.

Objective: to examine referrals of users at risk of developing chronic kidney disease by the Family Health Strategy teams to a specialized nephrology service. Method: in this cross-sectional study, data were collected in March 2021 from the medical records of users diagnosed with diabetes and high blood pressure, and monitored in primary care in Rio de Janeiro city. The research protocol was approved by the ethics committee. Results: serum creatinine was requested in 96% of the medical records, but the situation was different with the other exams. Referral was indicated most often at stage 3B (37% of the sample), followed by stage 4 (33%). Conclusion: as the course of this disease is insidious, laboratory monitoring must be carried out continuously. The role of Primary Care is unquestionable, but in view of the challenges highlighted, it is important to consider new strategies for more effective action and comprehensive care in the system.

Objetivo: analizar la derivación de usuarios con riesgo de desarrollar enfermedad renal crónica a un servicio especializado de nefrología por parte de los equipos de la Estrategia Salud de la Familia. Método: estudio transversal, con recolección de datos de las historias clínicas de usuarios con diagnóstico de diabetes e hipertensión arterial, cuyo seguimiento se realizó en la atención primaria de la ciudad de Rio de Janeiro, en marzo de 2021. El protocolo de investigación fue aprobado por el Comité de Ética en Investigación. Resultados: la solicitud de creatinina sérica fue identificada en el 96% de las historias clínicas, pero esa realidad fue diferente a los demás análisis. En cuanto a las etapas, la más indicada para la derivación fue la 3B que comprende el 37%, seguida de la etapa 4 que abarca el 33% de la muestra. Conclusión: al ser una enfermedad de curso insidioso, el seguimiento de laboratorio debe realizarse de forma continua. El rol de la Atención Primaria es incuestionable, sin embargo, frente a los desafíos señalados, es importante considerar nuevas estrategias para una mejor implementación de las acciones y la atención integral en la red.

Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development.

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurodegenerative disease that leads to motor impairment due to a chronic inflammatory process in the central nervous system (CNS). However, the HAM/TSP pathogenesis is not completely clear, and biomarkers to define the disease prognosis are still necessary. Thus, we aimed to identify biomarkers for HAM/TSP and potential mechanisms involved in disease development. To that end, the concentrations of VILIP-1, BDNF, VEGF, ß-NGF, TGF-ß1, fractalkine/CX3CL1, IL-6, IL-18, and TNF-α, and the soluble forms of TREM-1, TREM-2, and RAGE, were assessed using a multiplex bead-based immunoassay in paired cerebrospinal fluid (CSF) and serum samples from HAM/TSP patients (n = 20), asymptomatic HTLV-1 carriers (AC) (n = 13), and HTLV-1-seronegative individuals (n = 9), with the results analyzed according to the speed of HAM/TSP progression. HAM/TSP patients had elevated fractalkine in the serum but not in the CSF, particularly those with low neuroinflammatory activity (CSF/serum ratio of neopterin <1 and of CXCL10 < 2). HAM/TSP patients with normal CSF levels of neurofilament light chain (NfL) showed elevated ß-NGF in serum, and serum BDNF levels were increased in HTLV-1-infected individuals, particularly in HTLV-1 AC. Both HTLV-1 AC and HAM/TSP patients had lower TGF-ß1 levels in CSF compared to uninfected individuals, and HAM/TSP patients with active CNS inflammation showed higher CSF levels of IL-18, which correlated with markers of inflammation, neuronal death, and blood−brain-barrier permeability. Although none of the factors evaluated were associated with the speed of HAM/TSP progression, reduced TGF-ß1 levels in CSF suggest that suppressive responses to control subclinical and/or active neurodegeneration are impaired, while increased CSF IL-18 indicates the involvement of inflammasome-mediated mechanisms in HAM/TSP development.

Antioxidant Baccharis trimera Leaf Extract Suppresses Lipid Accumulation in C. elegans Dependent on Transcription Factor NHR-49.

Obesity is a global public health problem that is associated with oxidative stress. One of the strategies for the treatment of obesity is the use of drugs; however, these are expensive and have numerous side effects. Therefore, the search for new alternatives is necessary. Baccharis trimera is used in Brazilian folk medicine for the treatment of obesity. Here, B. trimera leaf extract (BT) showed antioxidant activity in seven in vitro tests, and it was not toxic to 3T3 murine fibroblasts or Caenorhabditis elegans. Furthermore, BT reduces the intracellular amount of reactive oxygen species and increases C. elegans survival. Moreover, these effects were not dependent on transcription factors. The inhibition of fat accumulation by BT in the C. elegans model was also investigated. BT reduced lipid accumulation in animals fed diets without or with high amount of glucose. Furthermore, it was observed using RNA interference (iRNA) that BT depends on the transcription factor NHR-49 to exert its effect. Phytochemical analysis of BT revealed rutin, hyperoside, and 5-caffeoylquinic acid as the main BT components. Thus, these data demonstrate that BT has antioxidant and anti-obesity effects. However, further studies should be conducted to understand the mechanisms involved in its action.

Repercussões no contexto familiar do paciente com câncer de próstata

Objetivo Analisar as repercussões no contexto familiar do paciente com câncer de próstata. Método Foi realizada uma pesquisa descritiva com abordagem qualitativa, que teve como participantes 10 homens com diagnóstico de câncer de próstata, que tinham convívio familiar e que estavam cadastrados no Programa do Tratamento Fora do Domicílio (TFD) do município de Ipiaú, Bahia. A coleta de dados foi realizada através de uma entrevista, seguindo um roteiro semiestruturado, com visitas no domicílio dos participantes. Resultados A maior incidência de pacientes com câncer de próstata está na faixa etária maior que 70 anos, comparando com idades inferiores. O carcinoma acomete homens acima de 65 anos e sua incidência é ascendente em homens da raça negra, quando comparados ao da raça branca. A história familiar é um grande fator de risco para a ocorrência desta doença. A falta de informação faz com que a maioria dos homens resista ao exame, por preconceito ou mesmo medo do desconhecido, podendo afetar sua qualidade de vida. Conclusão O estudo evidenciou a importância da participação da família no processo de descoberta do câncer, bem como durante o seu diagnóstico e tratamento, o que leva os pacientes a superarem as diversas dificuldades vivenciadas. Outro ponto relevante é o cuidado como fator de grande importância no atendimento ao paciente, sendo considerado como facilidade durante o tratamento.

Objective To analyze the repercussions in the family context of patients with prostate cancer. Method A qualitative descriptive study was carried out with ten men diagnosed with prostate cancer and with a family relationship, who were enrolled in the Out of Home Treatment Program (PDT) of the city of Ipiaú, Bahia. The data was collected through interviews, using a semi-structured script, and visits were made to the participants' homes. Results The highest incidence of prostate cancer occurs in men aged over 70 years, compared to those in younger age groups. Prostate carcinoma primarily affects men over the age of 65, with a higher incidence rate in black men than in white men. A family history of prostate cancer is a major risk factor for developing the disease. Despite this, many men are reluctant to undergo screening exams due to misinformation, prejudice, or fear of the unknown. This reluctance can significantly impact their quality of life. Conclusion The study highlighted the importance of family involvement in the process of cancer diagnosis, treatment, and recovery, as it can help patients overcome the various challenges they face. Additionally, the study identified the significance of proper care during treatment, which can significantly improve the patient's overall experience.

Objetivo Analizar el impacto en el contexto familiar del paciente con cáncer de próstata. Método Se realizó un estudio descriptivo con enfoque cualitativo, en el que participaron 10 hombres diagnosticados con cáncer de próstata y con relaciones familiares, inscritos en el Programa de Tratamiento Fuera del Domicilio (TFD) del municipio de Ipiaú, Bahía. La recolección de datos se llevó a cabo mediante entrevistas, utilizando un guión semi-estructurado, y se visitaron los hogares de los participantes. Resultados La mayor incidencia de cáncer de próstata se presenta en hombres mayores de 70 años, en comparación con las edades más jóvenes. El carcinoma prostático afecta principalmente a los hombres mayores de 65 años, con una tasa de incidencia más alta en hombres de raza negra que en los de raza blanca. Tener antecedentes familiares de cáncer de próstata es un factor de riesgo importante para la aparición de esta enfermedad. A pesar de esto, muchos hombres se muestran reacios a someterse a exámenes de detección debido a la falta de información, prejuicios o miedo a lo desconocido, lo que puede afectar significativamente su calidad de vida. Conclusión El estudio demostró la importancia de la participación de la familia en el proceso de detección, diagnóstico y tratamiento del cáncer, pues ayuda a los pacientes a superar las diversas dificultades. Otro punto relevante es el cuidado, que se considera un factor muy importante en el cuidado del paciente y puede mejorar significativamente su experiencia durante el tratamiento.

Chitotriosidase 1 in the cerebrospinal fluid as a putative biomarker for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) progression.

Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is an inflammatory neurodegenerative disease that affects motor, urinary, intestinal, and sensory functions. Typically, HAM/TSP is slowly progressive, but it may vary from limited motor disability after decades (very slow progression) to loss of motor function in a few years from disease onset (rapid). In this study, we aimed to identify prognostic biomarkers for HAM/TSP to support patient management. Thus, proteomic analysis of the cerebrospinal fluid (CSF) was performed with samples from HTLV-1 asymptomatic carriers (AC) (n=13) and HAM/TSP patients (n=21) with rapid, typical, and very slow progression using quantitative label-free liquid chromatography/tandem mass spectrometry. Enrichment analyses were also carried out to identify key biological processes associated with distinct neurological conditions in HTLV-1 infection. Candidate biomarkers were validated by ELISA in paired CSF and serum samples, and samples from HTLV-1-seronegative individuals (n=9) were used as controls. CSF analysis identified 602 proteins. Leukocyte/cell activation, immune response processes and neurodegeneration pathways were enriched in rapid progressors. Conversely, HTLV-1 AC and HAM/TSP patients with typical and very slow progression had enriched processes for nervous system development. Differential expression analysis showed that soluble vascular cell adhesion molecule 1 (sVCAM-1), chitotriosidase 1 (CHIT1), and cathepsin C (CTSC) were upregulated in HAM/TSP. However, only CHIT1 was significantly elevated after validation, particularly in HAM/TSP rapid progressors. In contrast, none of these biomarkers were altered in serum. Additionally, CSF CHIT1 levels in HAM/TSP patients positively correlated with the speed of HAM/TSP progression, defined as points in the IPEC-2 HAM/TSP disability scale per year of disease, and with CSF levels of phosphorylated neurofilament heavy chain, neopterin, CXCL5, CXCL10, and CXCL11. In conclusion, higher CSF levels of CHIT1 were associated with HAM/TSP rapid progression and correlated with other biomarkers of neuroinflammation and neurodegeneration. Therefore, we propose CHIT1 as an additional or alternative CSF biomarker to identify HAM/TSP patients with a worse prognosis.

Vida saudável? Os discursos construídos no Instagram pelo médico Mohamad Barakat / Healthy life? The discourses constructed by the doctor Mohamad Barakat on Instagram / ¿Vida saludable? Los discursos construidos por el médico Mohamad Barakat en Instagram

Em meio ao crescimento da participação de médicos nas mídias sociais digitais, este artigo objetiva analisar os discursos sobre vida saudável produzidos no Instagram pelo médico Mohamad Barakat (@doutorbarakat). O corpus é composto por stories selecionados a partir de uma coleta diária realizada ao longo de três meses em 2020. Como referencial teórico-metodológico recorre-se à semiótica discursiva e à semiótica plástica. Os resultados apontam a construção do discurso de vida saudável revestido por temas como rotina, estilo de vida, comportamento, aconselhamento e autocuidado, figurativizados por elementos de comprovação e reforçados pelo arranjo expressivo, em que a presença do médico é marcada por informalidade, intimidade e proximidade. Uma concepção de vida saudável que dialoga com a otimização de si discutida por Paula Sibilia e Marianna Ferreira Jorge e com a busca da aptidão levantada por Zygmunt Bauman

Amid growing physician participation in digital social media, this article aims to analyse the discourses on healthy living produced on Instagram by doctor Mohamad Barakat (@doutorbarakat). The corpus consists of stories selected from a daily collection carried out over three months in 2020. As a theoretical and methodological reference, discursive semiotics and plastic semiotics are used. The results reveal the construction of the healthy life discourse covered by themes such as routine, lifestyle, behaviour, counselling and self-care, figuratively represented by elements evidencing them and reinforced by the expressive arrangement, in which the presence of the doctor is characterized by informality, intimacy and proximity. A conception of healthy life that dialogues with the optimization of oneself discussed by Paula Sibilia and Marianna Ferreira Jorge and with the search for fitness approached by Zygmunt Bauman

En medio del crecimiento de la participación de los médicos en las redes sociales digitales, este artículo tiene como objetivo analizar los discursos sobre vida saludable producidos en el Instagram por el médico Mohamad Barakat (@doutorbarakat). El corpus está compuesto por relatos seleccionados de una compilación diaria realizada durante tres meses en 2020. Como referente teórico-metodológico, han sido utilizadas la semiótica discursiva y la semiótica plástica. Los resultados revelan la construcción del discurso de vida saludable revestido por temas como la rutina, el estilo de vida, el comportamiento, las recomendaciones y el autocuidado, figurado por elementos de comprobación y reforzados por el arreglo expresivo, en el cual la presencia del médico es caracterizada por la informalidad, intimidad y proximidad. Una concepción de vida saludable que dialoga con la optimización de sí mismo discutida por Paula Sibilia y Marianna Ferreira Jorge y con la búsqueda de la aptitud planteada por Zigmunt Bauman