Human immunodeficiency virus type 1 (HIV-1) and Mycobacterium leprae co-infection: HIV-1 subtypes and clinical, immunologic, and histopathologic profiles in a Brazilian cohort.

Co-infections with human immunodeficiency virus (HIV) and Mycobacterium leprae represent unique opportunities to investigate the interaction of both pathogens. We determined the immunologic, virologic, and histopathologic characteristics of 22 co-infected Brazilian patients (median age = 38 years, 81.8% males, 72.2% with paucibacillary leprosy, and 95.4% with acquired immunodeficiency syndrome). The HIV-1 subtypes B and BF predominated in envelope and gag heteroduplex mobility analysis. Borderline tuberculoid (BT), tuberculoid, lepromatous, and indeterminate morphology with CD3+, CD8+, and CD68+ cell distributions compatible with leprosy patients not infected with HIV were observed. Histologic evidence of nerve damage was observed in BT lesions. IgM antibody to M. leprae-specific phenolic glycolipid I was not detected. Two of six co-infected patients monitored during highly active antiretroviral therapy (HAART) developed a leprosy type 1 reaction after an increase in CD4+ cells, suggesting an immune restoration phenomenon. Clinical, immunologic, histopathologic, and virologic features among these HIV-leprosy co-infected patients indicate that each disease progressed as in single infection. However, HAART immune reconstitution may trigger potential adverse effects, such as leprosy acute inflammatory episodes.

Açäo "in vitro" do ivermectin sobre ovos de Lagochilascaris minor Leiper, 1909 / In vitro effect of ivermectin of the eggs of Lagochilascaris minor Leiper, 1909

Ovos uterinos de fêmeas L. minor, obtidos por eliminaçäo espontânea de abscessos cervicais da paciente W. M. R. (Pequizeiro- GO) - foram postos em contato com soluçäo de Ivermectin nas concentraçöes de 50, 100, 150, 200 e 250 microgramas. Os resultados demonstraram que a droga em todas as concentraçöes utilizadas näo impediu o desenvolvimento larvário. Entretanto, decorrida a embriogênese houve um processo de desvitalizaçäo da larva no interior do ovo caracterizado pela liberaçäo de uma massa amorfa a partir do ovo embrionado. Em ovos do grupo controle houve eclosäo de uma larva integra com todas as características estruturais de larva de Lagochilascaris

Notas parasitológicas sobre Lagochilascaríase humana em Goiás / Parasitological notes about human lagochilascariasis from Goiás

Temos , até o presente momento, 10 casos de lagochilascaríase humana diagnosticados em Goiás. Os autores chamam atençäo para a freqüência e distribuiçäo geográfica do parasito na área compreendida entr o norte do Estado e a regiäo sul do Pará (Amazônia Legal). Foram realizadas tentativas de reproduçäo experimental do ciclo evolutivo do verme com resultados infrutíferos