Corifollitropin alfa compared to daily rFSH or HP-HMG in GnRH antagonist controlled ovarian stimulation protocol for patients undergoing assisted reproduction.

OBJECTIVE: This study aimed to compare the outcomes of controlled ovarian stimulation (COS) with corifollitropin alfa versus daily recombinant follicle-stimulating hormone (rRFSH) or highly purified human menopausal gonadotropin (HP-HMG) in patients undergoing in vitro fertilization (IVF) cycles based on gonadotropin-releasing hormone (GnRH) antagonist protocols. The primary endpoints were total number of oocytes and mature oocytes. METHODS: This retrospective study looked into 132 controlled ovarian stimulation cycles from IVF or oocyte cryopreservation performed in a private human reproduction center between January 1 and December 31, 2014. Enrollment criteria: women aged < 40 years submitted to COS with corifollitropin alfa 100µg or 150µg (n = 26) and rFSH or HP-HMG in the first seven days of treatment with daily doses of 150-225 IU (n = 106); all subjects were on GnRH antagonist protocols. RESULTS: The groups had similar mean ages and duration of stimulation. The mean number ± standard deviation of total aspirated oocytes and MII oocytes was 11.9±10 and 10.3±7.9 in the corifollitropin alfa group, and 10.9±7.2 and 8.6±5.7 in the group on rFSH or HMG (p>0.05). There were no significant differences in fertilization (76.9% vs. 76.8%, p=1.0), biochemical pregnancy (66.7% vs. 47.2%, p=0.1561) or embryo implantation rates (68.7% vs. 50%, p=0.2588) between the groups using corifollitropin alfa and rFSH or HMG, respectively. CONCLUSIONS: Corifollitropin alfa seems to be as effective as rFSH or HP-HMG when used in the first seven days of ovulation induction for patients undergoing assisted reproduction in GnRH antagonist protocols.

Programa de educação pelo trabalho para a saúde nas escolas: oficina sobre sexualidade / The educational program for health work in schools: workshop on sexuality

Este artigo relata uma experiência de educação em saúde sobre sexualidade, conduzida por monitores do PET-Saúde, da Universidade de Brasília, do subgrupo de Planejamento Familiar. As oficinas foram realizadas com adolescentes de escolas públicas de ensino fundamental e médio dos municípios de Ceres e Santa Isabel, em Goiás. Foram abordadas questões sobre sexualidade; gravidez; métodos anticoncepcionais; doenças sexualmente transmissíveis. Os alunos, divididos em grupos, formularam as perguntas anonimamente e as responderam, por sorteio. Os monitores coordenaram as atividades, orientaram os alunos na elaboração das respostas e simularam o uso de métodos contraceptivos (preservativos masculino e feminino). A experiência evidenciou a importância do desenvolvimento de uma ação crítica, reflexiva e participativa para a promoção da saúde dos adolescentes, abordando-se o tema sexualidade dentro da realidade local. A intenção do trabalho foi estabelecer um meio eficaz e criativo de abordagem dessa temática no âmbito escolar em conjunto com o serviço de atenção básica desses municípios, favorecendo a integração ensino-serviço-comunidade, que é um dos objetivos principais do programa PET-Saúde.

This article reports on an experience in health education on sexuality led by monitors from the Educational Program for Health Work from the University of Brasília, belonging to the Family Planning subgroup. The workshops included teenagers from public elementary and secondary schools in the municipalities of Ceres and Santa Isabel, Goiás State. The workshops discussed issues on sexuality, pregnancy, contraceptive methods, and sexually transmitted diseases. The students, divided into groups, prepared the questions anonymously and answered them by random selection. The monitors coordinated the activities, oriented the students in elaborating the answers, and simulated the use of contraceptive methods (male and female condoms). The experience showed the importance of developing critical, reflexive, and participatory action for health promotion with teenagers, approaching the theme of sexuality within the local reality. The project's goal was to establish an effective and creative means for approaching this topic within the school setting, together with the primary care service in these communities, favoring integration between teaching, health services, and the community, one of the principal objectives of the Educational Program for Health Work.