Patient-reported outcomes and clinical performance of CAD/CAM removable dentures: A scoping review.

PURPOSE: This scoping review mapped the literature on CAD/CAM (computer-aided design and manufacturing) removable complete and partial dentures regarding patient and clinician-reported outcomes. MATERIALS AND METHODS: We performed an electronic search of the Cochrane Central Register of controlled trials (CENTRAL), MEDLINE (Ovid), EMBASE, SCOPUS, and Web of Science databases (last update: March 2023). All clinical trials or observational studies investigating CAD/CAM removable dentures (conventional or implant-retained) were included. RESULTS: The search yielded 4035 records and led to 58 included studies. Results suggest that CAD/CAM complete and partial dentures, when compared to the conventional ones, can save time and resources while being rated either non-inferior or superior by patients and clinicians in most studies. However, consensus on which workflow offers fewer adjustments and postoperative sessions is still pending. CONCLUSION: The literature suggests that CAD/CAM complete and partial dentures can combine substantial time and cost savings with patient and clinician experiences at least comparable to the conventional prostheses. Given the low evidence level of existing studies, future well-designed randomized trials with large sample size are required to confirm those advantages.

Discriminant Analysis of Anthropometric and Training Variables among Runners of Different Competitive Levels.

The purpose of this study was to investigate the multivariate profile of different types of Brazilian runners and to identify the discriminant pattern of the distinct types of runners, as a runners' ability to self-classify well. The sample comprised 1235 Brazilian runners of both sexes (492 women; 743 men), with a mean age of 37.94 ± 9.46 years. Individual characteristics were obtained through an online questionnaire: Sex, age, body height (m) and body mass (kg), socioeconomic status, and training information (i.e., self-classification, practice time, practice motivation, running pace, frequency and training volume/week). Multivariate analysis of variance was conducted by sex and the discriminant analysis was used to identify which among running pace, practice time, body mass index and volume/training could differentiate groups such as "professional athletes", "amateur athletes" and "recreational athletes". For both sexes, running pace was the variable that better discriminated the groups, followed by BMI and volume/week. The practice time is not a good indicator to differentiate runner's types. In both sexes, semi-professional runners were those that better self-classify themselves, with amateur runners presenting the highest classification error. This information can be used to guide the long-term training, athlete's selection programs, and to identify the strengths and weaknesses of athletes.

The Acute Effect of Hyperoxia on Onset of Blood Lactate Accumulation (OBLA) and Performance in Female Runners during the Maximal Treadmill Test.

The objective of this study was to analyze the acute effect of hyperoxia during the maximal treadmill test (MTT) of runners. Participants included 10 female street runners who performed the MTT under two different conditions: hyperoxia (HYPX), inhaling oxygen (60% O2) every 3 min; and normoxia (NORM), without additional oxygen inhalation. Both groups performed the MTT with increases in the slope of the run every 3 min until voluntary exhaustion. The variables of lactate concentration, the onset of blood lactate accumulation (OBLA), peripheral oxygen saturation (SpO2), heart rate (HR), and Borg scale were evaluated. It was verified after the comparison (HYPX vs. NORM) that stage 3 (p = 0.012, Cohen's d = 1.76) and stage 4 (p < 0.001; Cohen's d = 5.69) showed a reduction in lactate under the HYPX condition. OBLA under the HYPX condition was identified at a later stage than NORM. There were no differences in Borg scale, SpO2, and HR between the different conditions. It was concluded that the HYPX condition contributed to a reduction in lactate concentration and delayed OBLA in runners.

Impact of immediately loaded implant-supported maxillary full-arch dental prostheses: a systematic review.

OBJECTIVE: The immediate loading of implant-assisted fixed prostheses in edentulous maxillae may achieve favorable success rates with reduced treatment time. An evidence summary of clinical trials is key to recommend loading protocols in these cases. OBJECTIVES: To compare immediately loaded, fully implant-supported complete dentures to early and conventional/delayed loading in the edentulous maxillae of adult patients by a systematic review of controlled clinical trials (CCT). METHODOLOGY: CCTs reports were identified up to January 17, 2019 from Cochrane Oral Health Group's Trial register, Cochrane Central Register of controlled trials (CENTRAL), MEDLINE (Ovid), BIOSIS, EMBASE, CINAHL, Web of Science, and DARE. Two independent reviewers screened titles/abstracts and confirmed inclusion using full texts. Data were extracted and quality assessed (Cochrane Risk of Bias tool) independently and in duplicate. Study heterogeneity prevented pooling by meta-analysis. RESULTS: Out of 1,052 candidate studies, four CCTs were included. Two trials had patient satisfaction as an outcome: (1) A randomized trial compared immediately and early loaded fixed dentures and found more satisfaction with the first after 12 months; (2) A non-randomized study found better satisfaction with immediate fixed dentures compared to conventional loading after 3 months (no more at 12 months). Regarding implant success and prosthetic complications, three trials did not report significant differences comparing immediate loading to other protocols. CONCLUSIONS: This review found weak evidence of differences between immediate load and other loading regimens, regarding patient satisfaction and maintenance events/adversities. The potential of immediate loading for favorable results in edentulous maxillae reinforces the need for well-designed RCTs, for solid clinical guidelines. Registration number CRD42018071316 (PROSPERO database).

Impact of immediately loaded implant-supported maxillary full-arch dental prostheses: a systematic review

Abstract The immediate loading of implant-assisted fixed prostheses in edentulous maxillae may achieve favorable success rates with reduced treatment time. An evidence summary of clinical trials is key to recommend loading protocols in these cases. Objectives To compare immediately loaded, fully implant-supported complete dentures to early and conventional/delayed loading in the edentulous maxillae of adult patients by a systematic review of controlled clinical trials (CCT). Methodology CCTs reports were identified up to January 17, 2019 from Cochrane Oral Health Group's Trial register, Cochrane Central Register of controlled trials (CENTRAL), MEDLINE (Ovid), BIOSIS, EMBASE, CINAHL, Web of Science, and DARE. Two independent reviewers screened titles/abstracts and confirmed inclusion using full texts. Data were extracted and quality assessed (Cochrane Risk of Bias tool) independently and in duplicate. Study heterogeneity prevented pooling by meta-analysis. Results Out of 1,052 candidate studies, four CCTs were included. Two trials had patient satisfaction as an outcome: (1) A randomized trial compared immediately and early loaded fixed dentures and found more satisfaction with the first after 12 months; (2) A non-randomized study found better satisfaction with immediate fixed dentures compared to conventional loading after 3 months (no more at 12 months). Regarding implant success and prosthetic complications, three trials did not report significant differences comparing immediate loading to other protocols. Conclusions This review found weak evidence of differences between immediate load and other loading regimens, regarding patient satisfaction and maintenance events/adversities. The potential of immediate loading for favorable results in edentulous maxillae reinforces the need for well-designed RCTs, for solid clinical guidelines. Registration number CRD42018071316 (PROSPERO database).

O que é um estudo clínico randomizado? / What is a randomized clinical trial?

O estudo clínico randomizado (ECR) é uma das ferramentas mais poderosas para a obtenção de evidências para o cuidado à saúde. Apesar de algumas possíveis variações, baseiam se na comparação entre duas ou mais intervenções, as quais são controladas pelos pesquisadores e aplicadas de forma aleatória em um grupo de participantes. O objetivo deste artigo foi descrever aspectos relativos à validades externa e interna dos ECRs, bem como apresentar bases de dados para sua obtenção e ferramentas para avaliação de qualidade.

The randomized clinical trial (RCT) is one of the most powerful tools for the obtainment of evidence for health care. Despite some possible variations, they are based on the comparison between two or more interventions, which are controlled by researchers and randomly applied on a group of participants. The aim of this study was to describe aspects of external and internal validity of RCTs, as well as to present databases for their obtainment and quality assessment tools.