Biological response to endodontic treatment in one versus two-visit: a systematic review and meta-analysis of animal studies.

OBJECTIVES: To perform a systematic review of animal studies that compared the histopathological characteristics between teeth with apical periodontitis after endodontic treatment in one or two visits. MATERIALS AND METHODS: This systematic review was registered on the International Prospective Register of Systematic Reviews (PROSPERO) - CRD42022340849. Studies were collected from PubMed/MEDLINE, LILACS, EMBASE, Livivo, SciELO, Web of Science, Scopus, and Cochrane Library and manual and gray literature searches. Animal studies that evaluated histological characteristics after endodontic treatment of teeth with apical periodontitis in one or two visits were included. Risk of bias analysis of the included studies was performed using the Systematic Review Centre for Laboratory Animal Experimentation (SYRCLE) tool. Data synthesis of the included studies with quantitative data was performed, and meta-analysis was conducted with the Comprehensive Meta-Analysis software, using the random effects model and odds ratio (OR). RESULTS: Eighteen studies met the inclusion criteria (Kappa = 0.891). Meta-analyses indicated values in inflammatory infiltrate intensity with effect size of 5.5% (95% CI: 0.020-0.148; p < 0.001), periodontal ligament thickness: 25.6% (95% CI: 0.134-0.487; p < 0.001), dentin resorption: 13% (95% CI: 0.015-1.141; p = 0.066), cementum resorption: 7.1% (95% CI: 0.015-0.325; p = 0.001), bone resorption: 1.4% (95% CI: 0.002-0.130; p < 0.001), mineralized tissue resorption: 42.8% (95% CI: 0.110-1.671; p = 0.222), biological apical sealing: 13.1% (95% CI: 0.055-0.314; p < 0.001), and presence of microorganisms: 10.3% (95% CI: 0.014-0.747; p = 0.025). CONCLUSIONS: When considering animal studies, the two-visit endodontic treatment, using calcium hydroxide-based intracanal medication, resulted in better biological repair characteristics. CLINICAL RELEVANCE: A two-visit endodontic treatment with calcium hydroxide-based intracanal medication yields superior histopathological outcomes.

Edentulismo e fragilidade em pessoas idosas domiciliadas: um estudo transversal / Edentulism and frailty in domiciled older adults: a cross-sectional study

Resumo Objetivo Investigar a associação entre fragilidade e edentulismo em pessoas idosas domiciliadas e determinar os fatores individuais, sociodemográficos e clínicos associados. Método Participaram deste estudo 333 pessoas idosas com 65 anos ou mais; eles responderam ao instrumento Edmonton Frail Scale Instrument (EFS). Também foram coletados dados sobre fatores socioeconômicos, saúde bucal e uso e necessidade de próteses dentárias. Aqueles com dificuldades cognitivas foram excluídos. Foram realizadas regressões logísticas multivariadas por meio dos métodos stepwise e backward que testaram a relação da perda dentária e covariáveis com os resultados da EFS. Variáveis com p<0,20 nas análises não ajustadas foram incluídas na regressão logística ajustada. Resultados A prevalência de fragilidade moderada a grave foi de 12,3%. O edentulismo foi relacionado à fragilidade (OR 3,45; IC 95%: 1,45 - 8,25; p=0,01), idade (OR 2,19; IC 95%: 1,07 - 4,46; p=0,03), sexo feminino (OR 2,75; IC 95%: 1,23 - 6,15; p=0,01), necessidade de prótese dentária inferior (OR 3,19; IC 95%: 1,27 - 8,05; p=0,01) e percepção de dor de dente (OR 2,74; IC 95%: 1,15 - 6,15; p=0,02). Conclusões A fragilidade foi associada ao edentulismo, idade, sexo feminino, necessidade de prótese dentária inferior e percepção de dor de dente. Essas condições bucais são altamente prevalentes entre os idosos e podem ser prevenidas por políticas públicas e ações multiprofissionais. Os exames bucais devem ser considerados nas avaliações de pacientes pré-frágeis e frágeis, pois os indicadores de saúde bucal foram associados a fragilidade da pessoa idosa.

Abstract Objective To investigate the association between frailty and edentulism in community-dwelling older adults and determine the individual, sociodemographic, and clinical factors associated. Method A total of 333 older adults aged 65 years or more participated in this study; they responded to the Edmonton Frail Scale instrument (EFS). Data on socioeconomic factors, oral health, and use of and need for dentures were also collected. Those with cognitive difficulties were excluded. Hierarchical multivariable logistic regression models were performed using the stepwise and backward procedure, which tested the relationship of edentulism and covariates with EFS results. Variables with p<0,20 in the unadjusted analyzes were included in the adjusted logistic regression. Results The prevalence of moderate to severe frailty was 12.3%. Edentulism was related to frailty (OR 3,45; IC 95%: 1,45 - 8,25; p=0,01), age (OR 2,19; IC 95%: 1,07 - 4.46; p=0,03), female sex (OR 2,75; IC 95%: 1,23 - 6,15; p=0,01), the need of lower dental prosthesis (OR 3,19; IC 95%: 1,27 - 8,05; p=0,01) and toothache perception (OR 2,74; IC 95%: 1,15 - 6,15; p=0,02). Conclusions Frailty was associated with edentulism, age, female sex, the need for lower dental prosthesis and toothache perception. These oral conditions are highly prevalent among older adults and can be prevented by multiprofessional actions supported by public policies. Oral examinations should be considered in pre-frail and frail patients' assessments as oral health indicators were associated of older adults' frailty.