The predictive value of the clinical features of malignancy in cases of preoperative follicular thyroid neoplasia.

AIM: It is generally impossible to make a distinction between benign and malign with a cytopathological examination using a fine needle aspiration biopsy (FNAB) in follicular lesions of the thyroid gland. This is the reason why lesions are frequently reported as follicular neoplasia (FN). Our study aims to examine the predictive value of carcinoma detection of different clinical features in cases with determined FN with FNAB. METHODS: Clinical and histopathological data of a total of 116 patients (26 male, 90 female) subjected to surgery because of thyroid gland pathology with FN between March 1997 and December 2011 were retrospectively examined in two different centers. RESULTS: Results of the histopathological examinations were reported as: carcinoma in 33 (28.4%) cases (18 [54.5%] cases with papillary thyroid cancer, 11 [33.3%] cases with follicular thyroid cancer and 4 [12.1%] cases with papillary thyroid cancer follicular variant), as follicular adenoma (FA) in 32 (27.6%) patients and as a benign colloidal nodule in 51 (43.9%) patients. No statistical significance was determined between advanced age, male sex, solid single nodule, increased nodule diameter, hypoactive nodule existence and malignancy (P>0.05). CONCLUSION: Malignancy was found in 28.4% cases with FN detected as a result of FNAB in our study series, a ratio which is significantly higher than that reported in the literature. We think that the characteristics of the patient and the tumor are not effective in diagnosing cancer. In the case of the existence of bilateral thyroid pathology, the surgical therapy option should be bilateral total thyroidectomy due to such a high ratio of cancer occurrence.

Nitric oxide as an independent regulatory factor in regenerating rat liver.

Nitric oxide production and lipid peroxidation modulate the proliferating activity of liver cells, but the relationship between enhanced nitric oxide production, lipid peroxidation, and liver regeneration remains unclear. We examined the role of nitric oxide and lipid peroxidation on experimental liver regeneration. Thirty-five male Wistar albino rats underwent a sham operation (I), partial hepatectomy alone (II, IV), partial hepatectomy and daily N-nitro-L-arginine methyl ester (L-NAME) treatment for 24-hrs (III) or 48-hrs (V). Liver tissue concentrations of catalase, nitrite and nitrate, glutathione, and serum levels of alaninaminotransferase and bilirubin were measured. CD34, Ki-67 and proliferating cell nuclear antigen were evaluated in liver samples. Compared with other groups, both of the L-NAME groups had decreased tissue nitric oxide concentrations. Nitrate and nitrite (nitric oxide) concentrations were higher in partial hepatectomy-alone groups, as were CD34 counts and proliferation indexes. Partial hepatectomy elevated catalase, and glutathione levels in all groups compared to the sham-operated controls. In conclusion, nitric oxide inhibition impaired hepatic regeneration following partial hepatectomy. An obvious effect of nitric oxide on lipid peroxidation in the context of hepatocyte and endothelial cell proliferation could not be demonstrated. Thus, while lipid peroxidation could influence some steps in liver regeneration, nitric oxide poses as an independent regulatory factor in regenerating rat liver.