[E-cadherin in the serum and the peritoneal fluid of women with endometriosis]. / E-kadheryna w surowicy i plynie otrzewnowym kobiet z endometrioza.

Endometriosis, a disease of unclear etiopathogenesis, is a quite common problem in gynecology. It is thought that the retrograde flow of the menstrual debris to the peritoneal cavity plays an important role in the origin of endometriosis but the mechanism of endometrial cells implantation remains unknown. Recently many centers have reported the importance of adhesion molecules in this process. We studied the concentrations of E-cadherin in the serum and the peritoneal fluid of women with endometriosis. Our results show a significant decrease of E-cadherin concentrations in sera and peritoneal fluids in women with endometriosis. We suggest that screening the level of E-caherin may be useful in the monitoring the therapy of endometriosis.

[The risk factors of endometrial cancer]. / Czynniki powodujace stan zagrozenia kobiet rakiem blony sluzowej macicy.

Authors presents the risk factors in endometrial cancer underlying such problems like hyperestrogenism, both external and internal caused by hormonally active ovarian masses, polycystic ovarian syndrome, adrenocortical hyperfunction and role of obesity in this pathological state. Other factors have been also described diabetes mellitus and hypertension, oral contraception, genetics factors, patient's obstetric history and other diseases where the increase of aromatization activity of androstendion to estron has been noted.

[Ulcerative colitis and pregnancy]. / Wrzodziejace zapalenie jelita grubego i ciaza.

On the basis of literature and on the grounds of their own experience the authors presented their opinions on the coexistence of colitis ulcerosa (c.u.) and pregnancy. It was stressed that colitis ulcerosa does not decrease fertility in women whereas the taking of salazosulfapyridine diminishes fertility in men. Pregnancy should be planned during the remission period. Successive pregnancies in the same patient with coexistent c.u. should be taken individually. Classic pharmacotherapy end endoscopic diagnostics are not contraindicated in pregnancy. Past operation (e.g. partial or total colectomy) do not decrease chances of giving birth to a child. There is no evidence that artificial abortion exerts a favourable influence on the course of colitis ulcerosa. Cesarean section should be performed of obstetrical indications only. In addition, the authors emphasize the necessity of a strict monitoring of c.u. in the first trimester of pregnancy and during puerperium, as well as of a rigorous gynecological supervision in the third trimester of pregnancy.

[Use of partusisten in cases of placenta praevia and the incidence of respiratory distress syndrome in newborn infants]. / Zastosowanie partusistenu w przypadkach lozyska przodujacego a liczba wystepujacych zespolów samoistnych zaburzen w oddychaniu u noworodków.

Partusisten (Th 1165a, fenoterol) was given to 40 pregnant women aged from 19 to 39 years in whom ultrasonography demonstrated placenta praevia. Bleeding occurred between 21 and 36 weeks of pregnancy. The control group consisted of 44 pregnant women aged from 21 to 43 years not treated with partusisten. Bleeding in this group developed between 22 and 40 weeks of pregnancy. The authors conclude that partusisten use in cases of bleeding from placenta praevia in adequate doses and at adequate time make possible prolongation of pregnancy duration which increases the progression of lung maturation in the fetus and enabling reaching of relative biological maturity. This reduces the incidence of neonatal respiratory distress syndrome, and is the method of choice if genital bleeding develops prior to the 32nd week of pregnancy.