Assuntos
Hipersensibilidade/diagnóstico , Adolescente , Criança , Pré-Escolar , Humanos , Hipersensibilidade/epidemiologia , Itália , Testes CutâneosRESUMO
Plasma levels of isoniazid (INH) have been monitored in fifteen children, aged 1 to 13 years, who were under chronic therapy with INH plus rifampin for tuberculosis. The pharmacokinetic parameters of children were not significantly different from those found in adults by other authors. It is necessary to check two plasma concentrations at the 3rd h. versus different doses (5 mg/kg and 10 mg/kg) of INH, in order to determine the optimal dose to be given. In subjects with external ventricular drainage, the concentrations of INH in cerebro-spinal fluid are lower than in plasma. The latter finding should be stressed for its importance in the therapy of tuberculous meningitis.
Assuntos
Isoniazida/uso terapêutico , Tuberculose dos Linfonodos/tratamento farmacológico , Tuberculose Meníngea/tratamento farmacológico , Tuberculose Pulmonar/tratamento farmacológico , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Isoniazida/análogos & derivados , Isoniazida/sangue , Isoniazida/líquido cefalorraquidiano , Cinética , Masculino , Rifampina/uso terapêutico , Tuberculose Pulmonar/sangueRESUMO
Investigations for G6PD deficiency have been carried out among 900 subjects at the Paediatric Departments of the hospitals in Sestri Ponente and Pegli, in the western part of Genoa. 24 G6PD deficient males, 15 heterozygous and 1 homozygous females have been detected. Four variants, which have been encountered during the population survey, are reported. All of them, upon full characterization, were found to be unique new variants.
Assuntos
Deficiência de Glucosefosfato Desidrogenase/genética , Adulto , Criança , Feminino , Genética Populacional , Heterozigoto , Homozigoto , Humanos , Recém-Nascido , Itália , MasculinoRESUMO
This study was undertaken to determine, first the relationship between the Sabin-Feldman dye test and the enzyme-linked immunosorbent assay (ELISA) as far as the antitoxoplasmic IgG antibodies are concerned, and secondly the relationship between the indirect immunofluorescence test and the ELISA as regards the antitoxoplasmic IgM antibodies. The results achieved through this research show a good relationship between the dye test and IgG-ELISA, especially satisfactory with the low and medium values of the antibody titers. Furthermore, a very good agreement could be documented between IgM-ELISA and IgM-IFAT in the detection of IgM-specific antibodies in the early phases of toxoplasmic infection.
