Effect of rioprostil on the gastric acid and bicarbonate secretion in patients with gastric ulcer.

This double-blind trial is undertaken to study the effect of rioprostil on the acid and bicarbonate secretion in patients with gastric ulcer. Pentagastrin stimulation is performed before treatment and 9-20 days after the onset of treatment. In the four patients treated with rioprostil, the bicarbonate secretion increases and the parietal volume secretion decreases (p less than 0.05). The eight patients treated with ranitidine do not show an increase in bicarbonate secretion, but the decrease of the basal acid secretion is more prominent. The index of stimulated bicarbonate secretion/maximal acid output increases by 40% in those who are treated with rioprostil. This may be due to an increase in the cytoprotective activity and to a decrease in the aggressive activity of the gastric juice by rioprostil.

[A case of chronic recurrent pancreatitis with multiple severe complications]. / Vurkhu edin sluchai s khronichen retsidivirasht pankreatit s monozhestvo tezhki uslozhneniia.

A case of a man 33 years of age with severe hemorrhagic-necrotic chronic recurrent alcoholic pancreatitis is reported. The diagnosis was confirmed by clinical, laboratory-biochemical and ultrasound examinations. The last recurrence of the disease was marked by two cysts in the left hypochondrium proved by ultrasound examination. The laparoscopy revealed two very large pseudocysts filled with hemorrhagic liquid originating from the pancreas. In spite of the active postoperative treatment the patient died of severe hemorrhage--manifested by hematemesis, melaena and hemorrhagic shock. The postmortem examination revealed severe hemorrhagic-necrotic pancreatitis with sequestrations, pancreatic lithiasis and 3 large cysts in the abdomen: of the omentum, subhepatic and in the left hypochondrium as well as a perforated ventricular ulcer.