[Effect of lithium oxybutyrate on microcirculation in the mucous membrane of the hamster cheek pouch in the postischemic period]. / Vliianie oksibutirata litiia na mikrotsirkuliatsiiu v slizistoi obolochke zashchechnogo meshka khomiachka v postishemicheskom periode.

It was demonstrated in experiments on hamsters that lithium oxybutyrate (preliminary or therapeutic injection in a dose of 400 mg/kg) leads to relative normalization of microcirculation and secretory activity of the mast cells. Lithium oxybutyrate can be used for the prevention and treatment of postischemic disorders.

[Microcirculatory changes in experimental trigeminal neuralgia in rats]. / Izmeneniia mikrotsirkuliatsii pri éksperimental'noi trigeminal'noi nevralgii u krys.

Biomicroscopic studies of mesentery in trigeminal neuralgia rats caused by creation of a generator of pathologically enhanced excitation in trigeminal nerve caudal nucleus (injection 0.25-1.0 DLM Tetanus toxin) have shown the microcirculatory disorders, venular permeability, mast cells degranulation, and an increase in lymphatic contractile activity. Microcirculatory disorders intensity and adaptation reaction appearance correlated with trigeminal neuralgia clinical picture.

[The microcirculatory system in hamsters in a model of central pain syndromes]. / Sostoianie sistemy mikrotsirkuliatsii u khomiachkov v usloviiakh modelirovaniia tsentral'nykh bolevykh sindromov.

Experimental models of central pain syndromes, namely, trigeminal neuralgia (TN) and a pain syndrome of spinal origin, were developed in Syrian hamsters. Microhemocirculatory disorders, increased venular permeability, and increased mast cell degranulation in the mucosa of the cheek pouches were revealed. The importance of studying microcirculation in the cheek pouches of hamsters, especially in experimental TN is discussed, because appraisal of microcirculation in both pouches allows the beginning of generalization disorders to be determined.

[Effects of verapamil on behavioral and microcirculatory disorders in pain syndrome of spinal etiology]. / Vliianie verapamila na povedencheskie i mikrotsirkuliatornye narusheniia pri bolevom sindrome spinal'nogo proiskhozhdeniia.

In the experiments on Wistar rats with pain syndrome of spinal origin (PSSO) caused by the generator of pathologically enhanced excitation (GPEE) in dorsal horns of the spinal cord lumbosacral segments, it was shown that the intravenous verapamil injection (1.25 mg/kg) undoubtedly decreased behaviour response and improves the state of microcirculation. The compound of 10-fold decreased dose does not affect the behaviour response and microcirculation. When PSSO exists, the intravenous injection of analgin (150 mg/kg) produced an effect on the behaviour response and does not produce any action on microcirculation. When verapamil reaches the dorsal surface of the spinal cord (GPEE area) it decreases the behaviour response and microcirculation disorders created in PSSO. The obtained data make it clear that the GPEE depression caused by the verapamil calcium channel blocker weakens PSSO and normalizes the microcirculation.

[Effects of SP1-11 and its N-terminal fragment SP1-4 on several indices of the microcirculatory system in stress]. / Izuchenie deistviia SP1-11 i ego N-kontsevogo fragmenta SP1-4 na nekotorye pokazateli sistemi mikrotsirkuliatsii pri stresse.

In the experiments on rats it was shown that 5-hour immobilization induced the disturbances of terminal blood flow, degranulation of mast cells, increase of venular permeability and contractile activity of lymphaticus. I/p injection SP1-11 (125 micrograms/kg) before stress aggravated the disturbances caused by immobilization. The prophylactic i/p injection SP1-4 induced tranquilizing (100%), sedative (30%) or narcosis (20%) effect. In the rats with sedative or narcosis effects the relative normalization of components of microcirculatory system was observed.

[Globulin transport in the microcirculatory system under normal and stress conditions]. / Transport globulina na urovne mikrotsrkuliatornoi sistemy v usloviiakh normy i stressa.

Biomicroscopic studies of rat mesentery during 24-hours immobilization have shown phasic changes in globulin-FITC transport in the system: venule-interstitial-lymphatic microvessel. During short immobilization we have discovered the increasing contraction of lymphatic microvessels; during long immobilization--the decreasing contraction has been discovered.

[Dynamics of carrageenin-induced inflammation after use of lithium oxybutyrate]. / Dinamika karrageninovogo vospaleniia v usloviiakh primeneniia oksibutirata litiia.

Lithium hydroxybutyrate (200 mg/kg) has been shown to depress the development of carrageenan inflammation. Subcutaneous drug injection in chronic inflammation of the mucous membrane in the hamster cheek pouch restored the blood flow, checked dilatation of the blood vessels, decreased their permeability and prevented necrosis of the mucous membranes. Subcutaneous drug injection depressed all the signs of both phases of acute inflammatory reaction in the rat hind foot and promoted preservation of the hind foot function. Therefore, lithium hydroxybutyrate may be an effective preparation for the treatment of inflammation.

[Indices of acute inflammation against a background of lithium oxybutyrate action]. / Pokazateli ostrogo vospaleniia na fone deistviia oksibutirata litiia.

The experiments on rats have shown that intraperitoneal administration of silver nitrate solution induces peritonitis while subplantar histamine, serotonin and prostaglandin E2 administration leads to an acute paw edema. Preliminary subcutaneous injection of lithium hydroxybutyrate prevents the development of inflammation.

[Dynamics of the inflammatory process caused by carrageenin administration during experimental therapy]. / Dinamika protsessa vospaleniia, vyzvannogo vvedeniem karagenina, pri éksperimental'noi terapii.

Carrageenan is shown to cause acute inflammation in mucous membrane of hamster cheek pouch and rat hind foot. Rutin has no effect on the pathological process in the cheek pouch, and arrests the first phase of inflammation in the foot. Esculamine has a therapeutic effect on both phases of inflammatory reaction in the cheek pouch and foot.

[Effect of rutin and esculamine on models of aseptic inflammation]. / Vliianie rutina i éskulamina na nekotorye modeli aspeticheskogo vospaleniia.

It was shown in experiments on rats that intraabdominal administration of silver nitrate solution induces peritonitis and the subplantar administration of histamine, serotonin and prostaglandin E2 leads to an acute paw edema. Preliminary subcutaneous administration of esculamine or rutin inhibited the development of the inflammation. Esculamine proved more active here.