RESUMO
The role of teeth as lifestyle indicators of the past and present, and as key elements of evolutionary and forensic studies is explored. The wisdom of entrenched information in the structure of enamel, dentine and the DNA of dental pulp cells is being extracted by new technologies.
Assuntos
Esmalte Dentário , Dentina , Dente , Raiz DentáriaRESUMO
The craniofacial complex encapsulates the brain and contains the organs for key functions of the body, including sight, hearing and balance, smell, taste, respiration and mastication. All these systems are intimately integrated within the head. The combination of these diverse systems into a new field was dictated by the dental profession's desire for a research branch of basic science devoted and attuned to its specific needs. The traditional subjects of genetics, embryology, anatomy, physiology, biochemistry, dental materials, odontology, molecular biology and palaeoanthropology pertaining to dentistry have been drawn together by many newly emerging technologies. These new technologies include gene sequencing, CAT scanning, MRI imaging, laser scanning, image analysis, ultrasonography, spectroscopy and visualosonics. A vibrant unitary discipline of investigation, craniofacial biology, has emerged that builds on the original concept of 'oral biology' that began in the 1960s. This paper reviews some of the developments that have led to the genesis of craniofacial biology as a fully-fledged health science discipline of significance in the advancement of clinical dental practice. Some of the key figures and milestones in craniofacial biology are identified.
Assuntos
Odontologia/tendências , Odontologia/métodos , Genética , História do Século XIX , História do Século XX , História do Século XXI , Humanos , Paleodontologia , Tecnologia Odontológica/história , Dente/anatomia & histologia , Dente/embriologiaRESUMO
A review of recent insights into palaeodiets provided by new dating techniques, spectroscopy and attritional wear of enamel in ancient and recent human fossils. Fossilised dental plaque reveals changing dietary content and varying oral microbiota between Neolithic and Industrial era populations. DNA analysis of ancient dental pulpal tissue provides evidence of contemporary hereditary relationships and gene flow of human populations.
Assuntos
Evolução Biológica , Dente/fisiologia , Animais , Dieta , Hominidae/anatomia & histologia , Hominidae/fisiologia , Humanos , Homem de Neandertal/anatomia & histologia , Homem de Neandertal/fisiologia , Dente/anatomia & histologiaRESUMO
The current explosive growth in developmental biology, fuelled by the almost completed sequencing of the human genome, is bound to have a profound impact upon the practice of medicine and dentistry in the twenty-first century. No other discipline more accurately reflects this impact than embryology, which combines the basic and clinical sciences of genetics, ontogeny, phylogeny, teratology, and syndromology into the essence of modern medical and dental practice. The advent of in vitro fertilization, chorionic villus sampling, amniocentesis, prenatal ultrasonography, intrauterine surgery, and stem cell therapy has vaulted the previously esoteric subject of embryology into clinical consciousness. All these aforementioned procedures require an intimate knowledge of the different stages of development. The alphabet soup of acronyms that now peppers papers proclaiming the genetics and characteristics of various growth factors and cytokines (e.g., FGF, TGFalpha) are all based upon an understanding of the developmental mechanisms occurring in the embryo and subsequently in wound healing and oncology. Congenital abnormalities ranging from lethal syndromes to dental malocclusions cannot be diagnosed, treated, cured, or prognosticated upon without a sound conceptualization of embryology. Computer technology has revolutionized the understanding and teaching of embryology by portraying developmental phenomena as three-dimensional model images in sequential depictions of changes proceeding in the fourth dimension of time. Embryology must now form the essential core of the basic sciences in medical and dental curricula. Future dental practice will become rooted in the genetics and morphogenesis of facial fabrication.
Assuntos
Currículo , Educação em Odontologia , Embriologia/educação , Instrução por Computador , Anormalidades Congênitas/embriologia , Desenvolvimento Embrionário e Fetal , Face/embriologia , Genética/educação , Humanos , Morfogênese , Odontogênese , Filogenia , SíndromeRESUMO
It was the purpose of this study to investigate the craniofacial bones, cartilages and major blood vessels of a human anencephalic fetus and to describe the malformations of these structures accompanying this developmental disruption. The head of a 16 week old human fetus with anencephaly was serially sectioned and the craniofacial bones, cartilages and major blood vessels were traced and reconstructed by 3D-computer technology. The sphenoidal, temporal and occipital bones showed severe malformations, whereas the bones of the facial cranium were normally developed. Both internal carotid arteries ended within the cerebro-vascular area with no further branches. The vertebral arteries also ended within the cerebro-vascular area. No arterial circle of Willis was developed. The notochord terminated normally in the sphenoid body. The observations indicate that the possible reason for this malformation was non-closure of the anterior neuropore of the neural tube. The normal termination of the notochord suggests that it had no influence on the pathogenesis of this malformation. The malformations of the temporal and occipital bones are contradictory to the hypothesis of Marin-Padilla (1991) that anencephaly is caused by a maldevelopment of the sphenoidal bone.