Cardiac output measured by a new arterial pressure waveform analysis method without calibration compared with thermodilution after cardiac surgery.

OBJECTIVES: To investigate whether measuring cardiac output and its course after cardiac surgery by a new analysis technique of radial artery pressure waves, without need for calibration (FloTrac/Vigileo [FV]; Edwards Lifesciences, Irvine, CA), conforms to the standard bolus thermodilution method via a pulmonary artery catheter (PAC). DESIGN: Prospective study. SETTING: Intensive care unit of university hospital. PARTICIPANTS: Twenty patients for up to 24 hours after cardiac surgery. INTERVENTIONS: Simultaneous and triplicate PAC thermodilution and FV cardiac output measurements at 1 and 3 hours after surgery and the following morning. MEASUREMENTS AND MAIN RESULTS: Fifty-six simultaneous measurement sets were obtained. Mean cardiac output (PAC) ranged between 2.8 and 10.3 L/min and for the FV method between 3.3 and 8.8 L/min. The coefficient of variation for pooled measurements was 7.3% for the PAC and 3.0% for the FV method. For pooled data, the r2 was 0.55 (p < 0.001), with a bias of -0.14, precision of 1.00 L/min, and 95% limits of agreement between -2.14 and 1.87 L/min in a Bland-Altman plot. Also, the FV method tended to overestimate cardiac output when <7 L/min and increased with time, whereas mean arterial pressure increased and PAC cardiac output did not change. Changes in cardiac output correlated (r2 = 0.52, p < 0.001). CONCLUSIONS: The FV arterial pressure waveform analysis method is a clinically applicable method for cardiac output assessment without calibration, after cardiac surgery. It performs well at low cardiac outputs but remains sensitive to changes in vascular tone.

Attenuated renal and intestinal injury after use of a mini-cardiopulmonary bypass system.

BACKGROUND: Transient, subclinical myocardial, renal, intestinal, and hepatic tissue injury and impaired homeostasis is detectable even in low-risk patients undergoing conventional cardiopulmonary bypass (CPB). Small extracorporeal closed circuits with low priming volumes and optimized perfusion have been developed to reduce deleterious effects of CPB. METHODS: A prospective, randomized trial was conducted in 49 patients undergoing elective coronary artery bypass graft surgery either with the use of a standard or mini-CPB system (Synergy). We determined early postoperative inflammatory response (leukocytosis, C-reactive protein, urine interleukin-6), platelet consumption and activation (urine thromboxane B2), proximal renal tubular injury (urine N-acetyl-glucosaminidase), and intestinal injury (intestinal fatty acid binding protein). RESULTS: In patients undergoing coronary artery bypass grafting with a mini-CPB system, we observed decreased priming volumes with subsequent attenuation of on-pump hemodilution, improved hemostatic status with reduced platelet consumption and platelet activation, decreased postoperative bleeding and minimized transfusion requirements. We also found reduced leukocytosis and decreased urinary interleukin-6. Levels of urine N-acetyl-glucosaminidase were on average threefold lower, and urinary intestinal fatty acid binding protein was 40% decreased in the patients on the mini-CPB system, as compared with standard CPB. CONCLUSIONS: The use of the mini-CPB system during myocardial revascularization represents a viable nonpharmacologic strategy that can attenuate the alterations in the hemostatic system, reduce bleeding and transfusion requirements, decrease systemic inflammatory response, and reduce immediate postoperative renal and intestinal tissue injury.