[Research on anti-diphtheria immunization in the city of Bucharest]. / Investigatii privind imunizarea antidifterica în municipiul Bucuresti.

Biological, sero-epidemiological and bacteriological investigations, carried out in the town of Bucharest for evaluating the present diphtheria vaccination programme showed: -- high anatoxin titers, exceeding the titer considered as protective, in the vaccinates ; -- a concentration of the level of the titers of 1--4 AU/ml, in over 62% of the subjects, which means that the protective titer was exceeded 33 to lucru: -- negative Schick reaction, in the mean 95.06%, in the subjects examined during the 1969--1975 period; -- isolation of the Bacillus diphtheriae in a proportion of 0.08%, none of the toxigenic gravis type. The authors, correlating these data, consider the present vaccination calendar too loaded both as number of inoculations and as antigen concentration per revaccination dose, and recommend reconsideration of the vaccination programme.

[Sero-epidemiological surveillance, a method of prevention of complications of streptococcal infections]. / Supravegherea seroepidemiologica - metoda de profilaxie a complicatiilor poststreptococice

In order to find methods for the prevention and control of streptococcal infections of 711 day schoolchildren and boarders, aged 7 to 14 years, were followed up during the 1969-1973 period. The clinical and epidemiologic investigations revealed a great number of acute infections with varied clinical manifestations and high proportions of the acute articular rheumatism (3.1%) in the boarding schools as compared to the day schools (0.5%). The bacteriologic examinations confirmed and established the etiology of the cases, revealing moreover the role of carriers in maintaining and spreading the infection. The ASLO test showed persistent and high gammaglobulin titers in the children of the boarding schools, pointing to a state of hypersensitivity consequent to repeated streptococcal infections.