RESUMO
The diagnostic value of five staphylococcal allergens prepared from a single S. aureus strain by different methods and in different institutions has been tested on the experimental models of delayed, immediate and mixed (immediate and delayed) hypersensitivity in guinea pigs. The advantages of the allergens prepared in Kazan (USSR) for the detection of delayed hypersensitivity and the ultrasonicated allergen, as well as the allergen made in Czechoslovakia, for the detection of immediate hypersensitivity have been noted.
Assuntos
Alérgenos , Staphylococcus aureus/imunologia , Alérgenos/isolamento & purificação , Anafilaxia/diagnóstico , Animais , Inibição de Migração Celular , Avaliação Pré-Clínica de Medicamentos , Cobaias , Hipersensibilidade Tardia/diagnóstico , Hipersensibilidade Imediata/diagnóstico , Imunização/métodos , Leucócitos/imunologia , Testes Cutâneos/métodosRESUMO
The study made on the experimental models of delayed hypersensitivity (DH) to S. aureus strains Cowan-1 and Wood-46 has shown that acrylic acid/N-vinylpyrrolidone copolymers enhance the development of DH reactions at early periods of sensitization.