RESUMO
PIP: The effects of oral contraceptives on serum lipids were investigated in humans and monkeys at the Temple University Health Sciences Center. The compositions of the pills were: 1) 2.0 mg chlormadinone acetate, .08 mg mestranol; 2) 10.0 mg medroxyprogesterone acetate, .05 mg ethinyl estradiol; 3) 1.0 mg ethynodiol diacetate, .1 mg mestranol; 4) 1.0 mg norethindrone acetate, .05 mg ethinyl estradiol, and 5) .5 mg norgestrel, .05 mg ethinyl estradiol. 238 immediately puerperal black women, healthy and aged 20-30, were divided into 6 groups for study purposes; each of 5 groups used a separate oral therapy, while the sixth group (control) was fitted with a plastic intrauterine device. 75 women were still participating in the study at 54 weeks. All of the drugs significantly increased the concentrations of serum cholesterol, serum triglycerides, total phospholipids, and fatty acids. The influence of the drugs on lipoproteins was variable. The higher its progestogen/estrogen ratio, the greater influence a drug had on lipid concentrations. Some of the same effects were seen in 14 mature female squirrel monkeys (Cebus albifrons), which were studied in a similar manner for about 30 cycles; however, only drugs 1, 2, and 3 were used in this part of the study. Clinical observations of the patients in this study, showed no relationship between serum phosphatides participating in the coagulation mechanism and the production of thromboembolic phenomena. The researchers found no justification for the delay of oral contraceptive prescription after childbirth.^ieng
