The Herschel-Quincke tube with modulated branches.

The Herschel-Quincke (HQ) tube concept for transmission loss in pipe systems is expanded to include cases of branches with modulated properties. Modulated waveguides, featuring corrugations in their geometry or speed of sound, are known to produce significant reflection even without the parallel branch of the HQ tube. The HQ tube, in its classical form, produces narrow banded transmission loss at frequencies related to the length, wavenumber and cross-section area of the parallel branch. The modulated Herschel-Quincke (MHQ) tube combines these attributes to produce enhanced transmission loss characteristics in terms of both width and number of transmission loss bands. Several modulated profiles for the speed of sound in different branches of the tube are considered and analytical expressions for the transmission loss and resonant conditions are derived. Detailed analysis of periodically stratified branch profiles demonstrates the effectiveness of the MHQ tube for fluid-borne noise attenuation in pipe systems. This article is part of the theme issue 'Wave generation and transmission in multi-scale complex media and structured metamaterials (part 2)'.

A device for high-throughput monitoring of degradation in soft tissue samples.

This work describes the design and validation of a novel device, the High-Throughput Degradation Monitoring Device (HDD), for monitoring the degradation of 24 soft tissue samples over incubation periods of several days inside a cell culture incubator. The device quantifies sample degradation by monitoring its deformation induced by a static gravity load. Initial instrument design and experimental protocol development focused on quantifying cartilage degeneration. Characterization of measurement errors, caused mainly by thermal transients and by translating the instrument sensor, demonstrated that HDD can quantify sample degradation with <6 µm precision and <10 µm temperature-induced errors. HDD capabilities were evaluated in a pilot study that monitored the degradation of fresh ex vivo human cartilage samples by collagenase solutions over three days. HDD could robustly resolve the effects of collagenase concentration as small as 0.5 mg/ml. Careful sample preparation resulted in measurements that did not suffer from donor-to-donor variation (coefficient of variance <70%). Due to its unique combination of sample throughput, measurement precision, temporal sampling and experimental versality, HDD provides a novel biomechanics-based experimental platform for quantifying the effects of proteins (cytokines, growth factors, enzymes, antibodies) or small molecules on the degradation of soft tissues or tissue engineering constructs. Thereby, HDD can complement established tools and in vitro models in important applications including drug screening and biomaterial development.