RESUMO
The characteristic slowness of movement initiation and execution in adult individuals with mental retardation may be driven by the slower frequency profile of the dynamics of the system. To investigate this hypothesis, we examined the resting and postural finger tremor frequency profile (single and dual limb) of adults as a function of level of mental retardation (moderate, severe, profound). There was a progressive increase in the contribution of slow frequency components to the enhanced amplitude of tremor as a function of mental retardation, particularly in the group with profound mental retardation. Findings support the hypothesis of mental retardation inducing a slower frequency to the system dynamics that may fundamentally drive the characteristic slowness of movement behavior.
Assuntos
Deficiência Intelectual/epidemiologia , Periodicidade , Tremor/epidemiologia , Adulto , Eletrofisiologia/métodos , Feminino , Dedos/fisiopatologia , Humanos , Masculino , Transtornos dos Movimentos/diagnóstico , Transtornos dos Movimentos/epidemiologia , Transtornos dos Movimentos/fisiopatologia , Postura , Índice de Gravidade de Doença , Tremor/diagnóstico , Tremor/fisiopatologiaRESUMO
The effect of neuroleptic withdrawal on postural task performance of 20 adults with mental retardation was examined. Dyskinesia was measured using the DISCUS rating scale and postural stability using a force platform during a prospective longitudinal neuroleptic medication withdrawal protocol. Assessments were conducted at baseline and monthly intervals, extending to approximately one year following complete medication withdrawal, when significant changes in amount of postural motion and sequential pattern of postural movement complexity were observed. Postural task performance tended to return to near baseline levels at periods of up to 1 year following medication withdrawal, although one third of the subjects continued to display atypical postural motion profiles at follow-up. Results provide within-subject evidence that tardive dyskinesia is associated with generalized changes in motor control and not simply peripheral disturbances of movement.
Assuntos
Antipsicóticos/efeitos adversos , Discinesia Induzida por Medicamentos/diagnóstico , Discinesia Induzida por Medicamentos/psicologia , Deficiência Intelectual/tratamento farmacológico , Postura , Síndrome de Abstinência a Substâncias/psicologia , Adulto , Análise de Variância , Humanos , Estudos de Amostragem , Análise e Desempenho de Tarefas , Fatores de TempoAssuntos
Academias e Institutos , Má Conduta Científica , Controles Informais da Sociedade , Responsabilidade Social , Universidades , Atitude , Pesquisa Biomédica , Economia , Ética Profissional , Docentes , Humanos , Desenvolvimento Moral , Princípios Morais , Motivação , Organização e Administração , Política Organizacional , Papel Profissional , Pesquisa , Pesquisadores , Ciência , Predomínio Social , Valores Sociais , Estresse Psicológico , Estados UnidosRESUMO
This article presents a first-person account of the events surrounding the investigation and sanctioning of Stephen E. Breuning for scientific fraud. The adverse consequences to the whistleblower in this case are also discussed in detail.
