[The Linz model: separation--divorce--new beginning]. / Das Linzer Modell: Trennung--Scheidung--Neubeginn.

The Linz-Project is a secondary-preventive and therapeutic model for coping with divorce. It contains a children's group (for children with age 8-12) and parallelly a parent group. The authors describe context, theoretical and practical fundamentals, aims, methods, basic structure and process of this specific group model. Their article outlines similarities and differences to other group models for coping with divorce and resumes the experiences with the Linz-Project.

Disposition of 17 beta-trenbolone in humans.

The urinary excretion and metabolic pattern of 17 beta-trenbolone, a synthetic anabolic steroid hormone used as a growth promotor for beef cattle in several countries, has been studied in a human subject. For the separation of the metabolites of 17 beta-trenbolone, a reversed-phase high-performance liquid chromatographic method was established. The method was tested with metabolites obtained from incubation of 17 beta-trenbolone with rat liver microsomes. Fifteen metabolites could be well separated in one run by using a concave acetonitrile-water-methanol gradient. After ingestion of the tracer-labelled hormone at a dose of 0.04 mg/kg body weight 54% of the administered radioactivity was found in the urine after 26 h and 63% after 72 h. Of the urinary material 54% was present as glucuronides, which contained mostly 17 alpha-trenbolone, 17 beta-trenbolone and trendione. At least five other polar metabolites, presumably hydroxylated products, were found in smaller amounts, mostly in the unconjugated and sulphated fractions. Thus, the disposition of 17 beta-trenbolone in humans differs significantly from that in rats, which may have a bearing on the toxicological evaluation of the hormone.