Effects of exercise anticipation on cardiorespiratory coherence.

In this study, we explored the role of feedforward mechanisms in triggering cardiorespiratory adjustments before the onset of exercise. To isolate the feedforward aspects, we examined the effect of exercise anticipation on cardiorespiratory coherence. Twenty-nine healthy males (age = 18.8 [0.96] years) were subjected to bicycle (BE) and handgrip exercise (H) at two different intensities, viz., low and high. Bicycle exercise was performed in a unilateral (left- and right-sided) or bilateral mode, whereas handgrip was performed only in a unilateral mode. Single-lead ECG and respiratory rhythm, measured in the 5 min of anticipation phase before the onset of exercise, were used for analysis. Coherence was computed between ECG-derived instantaneous heart rate and respiratory signal. Average coherence in the high-frequency band (0.15-0.4 Hz) was used to estimate respiratory sinus arrhythmia (RSA). We found that coherence decreased with the anticipation of exercise relative to baseline (baseline = 0.54 [0.16], BE = 0.41 [0.12], H = 0.39 [0.12], p < 0.001). The decrease was greater for high intensity exercise (low = 0.42 [0.11], high = 0.37 [0.1], p < 0.001). The fall of coherence with intensity was stronger for bicycle exercise (BE: low = 0.44 [0.12], high = 0.37 [0.12], H: low = 0.4 [0.12], high = 0.37 [0.12], p = 0.00433). The expectation of bilateral exercise resulted in lower coherence compared to unilateral exercise (right-sided = 0.45 [0.16], left-sided = 0.4 [0.16], bilateral = 0.36 [0.15], unilateral vs. bilateral: p < 0.001), and the left-sided exercise had lower coherence compared to that of the right (left-sided vs. right-sided: p = 0.00925). Handgrip exercise showed similar trend (right-sided = 0.4 [0.15], left-sided = 0.37 [0.14], p = 0.0056). In conclusion, feedforward RSA adjustments in anticipation of exercise covaried with subsequent exercise-related features like intensity, muscle mass (unilateral vs. bilateral), and the exercise side (left vs. right). The left versus the right difference in coherence indicates autonomic asymmetry. Feedforward changes in RSA are like those seen during actual exercise and might facilitate the rapid phase transition between rest and exercise.

Feasibility of home-based tracking of insulin resistance from vascular stiffness estimated from the photoplethysmographic finger pulse waveform.

Objective.In this study we explored the utility of post-prandial vascular stiffness as a surrogate measure for estimating insulin resistance, which is a pre-diabetic condition.Approach.A cohort of 51 healthy young adults with varying body mass index (BMI) values was studied using fasting plasma values of insulin and glucose, fasting and post-meal finger photoplethysmography (PPG) and electrocardiogram (ECG). Insulin resistance was estimated by homeostatic model assessment for insulin resistance 2 (HOMA-IR2) using fasting plasma insulin and glucose. Vascular stiffness was estimated by reciprocal of pulse arrival time (rPAT) from ECG and finger PPG at five time points from fasting to 2 h post-oral glucose ingestion. We examined if insulin resistance correlates with meal-induced vascular stiffness changes, supporting the feasibility of using finger PPG to estimate insulin resistance.Main results.HOMA-IR2 was positively correlated with an early rise (0 to 30 min post-meal) and delayed fall (30 to 120 min post-meal) of rPAT. Correlation persisted even after the effect of BMI has been partialled out in subgroup analysis. We conclude that finger PPG-based pulse waveform and single-lead ECG has the potential to be used as a non-invasive method for the assessment of insulin resistance.Significance.As both signals, namely ECG and PPG, can be easily acquired using wearable and other low-cost sensing systems, the present study can serve as a pointer to develop accessible strategies for monitoring and longitudinal tracking of insulin resistance in health and pathophysiological states.

Using epidemic simulators for monitoring an ongoing epidemic.

Prediction of infection trends, estimating the efficacy of contact tracing, testing or impact of influx of infected are of vital importance for administration during an ongoing epidemic. Most effective methods currently are empirical in nature and their relation to parameters of interest to administrators are not evident. We thus propose a modified SEIRD model that is capable of modeling effect of interventions and inward migrations on the progress of an epidemic. The tunable parameters of this model bear relevance to monitoring of an epidemic. This model was used to show that some of the commonly seen features of cumulative infections in real data can be explained by piecewise constant changes in interventions and population influx. We also show that the data of cumulative infections from twelve Indian states between mid March and mid April 2020 can be generated from the model by applying interventions according to a set of heuristic rules. Prediction for the next ten days based on this model, reproduced real data very well. In addition, our model also reproduced the time series of recoveries and deaths. Our work constitutes an important first step towards an effective dashboard for the monitoring of epidemic by the administration, especially in an Indian context.

Differentiated effects of deep brain stimulation and medication on somatosensory processing in Parkinson's disease.

OBJECTIVES: Deep brain stimulation (DBS) and dopaminergic medication effectively alleviate the motor symptoms in Parkinson's disease (PD) patients, but their effects on the sensory symptoms of PD are still not well understood. To explore early somatosensory processing in PD, we recorded magnetoencephalography (MEG) from thirteen DBS-treated PD patients and ten healthy controls during median nerve stimulation. METHODS: PD patients were measured during DBS-treated, untreated and dopaminergic-medicated states. We focused on early cortical somatosensory processing as indexed by N20m, induced gamma augmentation (31-45Hz and 55-100Hz) and induced beta suppression (13-30Hz). PD patients' motor symptoms were assessed by UPDRS-III. RESULTS: Using Bayesian statistics, we found positive evidence for differentiated effects of treatments on the induced gamma augmentation (31-45Hz) with highest gamma in the dopaminergic-medicated state and lowest in the DBS-treated and untreated states. In contrast, UPDRS-III scores showed beneficial effects of both DBS and dopaminergic medication on the patients' motor symptoms. Furthermore, treatments did not affect the amplitude of N20m. CONCLUSIONS: Our results suggest differentiated effects of DBS and dopaminergic medication on cortical somatosensory processing in PD patients despite consistent ameliorating effects of both treatments on PD motor symptoms. SIGNIFICANCE: The differentiated effect suggests differences in the effect mechanisms of the two treatments.

Worsening of Verbal Fluency After Deep Brain Stimulation in Parkinson's Disease: A Focused Review.

Worsening of verbal fluency after treatment with deep brain stimulation in Parkinson's disease patients is one of the most often reported cognitive adverse effect. The underlying mechanisms of this decline are not well understood. The present focused review assesses the evidence for the reliability of the often-reported decline of verbal fluency, as well as the evidence for the suggested mechanisms including disease progression, reduced medication levels, electrode positions, and stimulation effect vs. surgical effects. Finally, we highlight the need for more systematic investigations of the large degree of heterogeneity in the prevalence of verbal fluency worsening after DBS, as well as provide suggestions for future research.