Sniffing out pain: An in vivo intranasal study of analgesic efficacy.

BACKGROUND: Orofacial pain is a common encounter in dentistry (affecting 12% of the population) and is a primary reason for patients seeking emergency care. Dentists often prescribe oral analgesics, which have disadvantages of decreased absorption rates and delayed onset. Intranasal (IN) delivery takes advantage of a large surface area of mucosal tissue for rapid absorption. The purpose of this study was to evaluate the efficacy of IN ketorolac for endodontic pain using a randomized, double-blind, placebocontrolled parallel design study. MATERIALS & METHODS: Twenty patients presenting with moderate to severe endodontic pain were selected to receive IN treatment with placebo (n = 10) or ketorolac (n = 10) 30 minutes before endodontic treatment was started and immediately after the completion of endodontic treatment. Baseline pain levels were recorded before IN treatment. Pain levels were also recorded at 15 and 30 minutes after the initial IN dosing (before endodontic treatment); 30 minutes after completion of endodontic treatment; and 4, 8, and 12 hours after the initial IN spray. RESULTS: IN ketorolac alone or with endodontic treatment showed significantly better pain relief compared with IN placebo spray alone or with endodontic treatment at 30 minutes after the first or second intranasal dose and at 4 hours after the first intranasal dose. CONCLUSIONS: These results suggest that IN ketorolac may provide a novel and efficacious method for pain relief in endodontic pain patients. How to cite the article: Maroli S, Srinath HP, Goinka C, Yadav NS, Bhardwaj A, Varghese RK. Sniffing out pain: An in vivo intranasal study of analgesic efficacy. J Int Oral Health 2014;6(1):66-71.

To evaluate and compare the porosities in the acrylic mandibular denture bases processed by two different polymerization techniques, using two different brands of commercially available denture base resins - an in vitro study.

BACKGROUND: The aim of this study was to evaluate and compare the porosities in the mandibular acrylic denture bases processed by heat and microwave polymerization techniques, using two different brands of commercially available denture base resins. MATERIALS & METHODS: Two brands of heat activated denture base resins, DPI plain and Acralyn H cross linked denture base resins designed for conventional water bath polymerization, were used to prepare 48 test specimens of mandibular acrylic denture bases. The test specimens were processed using one cycle of conventional water bath polymerization and one cycle of microwave polymerization. The absolute density of acrylic resin was used to calculate the percent mean porosity of each mandibular acrylic denture base by use of various equations. RESULTS: Anova analysis reveals highly significant difference between mean percent porosity values of whole denture bases of all groups. Statistics reveals that heat polymerized groups have lesser mean percent porosity values than microwave polymerized groups. It also reveals that denture bases processed with Acralyn H cross linked denture base resin have lesser mean percent porosity values than denture bases processed with DPI Plain denture base resin. CONCLUSION: Specimens processed with Acralyn H cross linked denture base resin by conventional heat polymerization technique has the least mean percent porosity and specimens processed with DPI Plain denture base resin by microwave polymerization technique has the highest mean percent porosity. How to cite the article: Kasina SP, Ajaz T, Attili S, Surapaneni H, Cherukuri M, Srinath HP. To evaluate and compare the porosities in the acrylic mandibular denture bases processed by two different polymerization techniques, using two different brands of commercially available denture base resins - an in vitro study. J Int Oral Health 2014;6(1):72-7.