RESUMO
BACKGROUND: Nitric oxide was used as an important selective vasodilator in the treatment of acute respiratory failure accompanied with high pulmonary resistance in children and adults since late 80's. METHODS AND RESULTS: Paper includes remarks about nitric oxide physiology in organism. Group of 33 patients is presented (group I 26 newborns, group II 7 children) in which selective pulmonary vasodilation with nitric oxide was used. According to response to NO subject were classified into subgroups of responders, non-responders. In evaluation of oxygenation status OI (oxygenation index, A-a DO2 (alveoloarterial difference) and paO2/FiO2 were used. CONCLUSIONS: Significant differences of above mentioned values were revealed between responders and non-responders in group I (newborns). Significant differences were not revealed in group II (children). Results are in accordance with other papers.
Assuntos
Óxido Nítrico/uso terapêutico , Insuficiência Respiratória/tratamento farmacológico , Vasodilatadores/uso terapêutico , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , Síndrome da Persistência do Padrão de Circulação Fetal/complicações , Síndrome da Persistência do Padrão de Circulação Fetal/tratamento farmacológico , Insuficiência Respiratória/etiologia , Insuficiência Respiratória/fisiopatologiaRESUMO
Natrium nitrosum intoxication is usually associated with a subsequent methemoglobinemia. Beside it, nitrates can cause also some other pathological states. Treatment with the toluidine blue may have various adverse side effects. Newborn intoxication by natrium nitrosum developing after the intoxication of the bearing mother before the parturition has not been described yet. Our own observation is referred.
