1.
Acta Biol Med Ger
; 39(1): 149-55, 1980.
Artigo
em Alemão
| MEDLINE
| ID: mdl-6968492
RESUMO
Single intravenous administration of 8 mg/kg of di-n-octyltin dichloride (DOTC) induced in mice a reversible decrease of thymus weight, thymocyte count and antibody titer against sheep red blood cells. After 14 days the values of treated animals were not lower than the values of control groups. The proportion of T and B lymphocytes in spleen and lymph nodes was found unchanged 4--5 days after administration of DOTC. concentrations of DOTC measured in thymus and spleen of treated mice were in the range of concentrations which are toxic for thymocytes and macrophages in vitro. The activity of di-n-alkyltin salts on the thymus of mice was independent of the length of the alkyl chains in the range of 4--8 C atoms.
Assuntos
Formação de Anticorpos/efeitos dos fármacos , Linfócitos/efeitos dos fármacos , Compostos Orgânicos de Estanho/farmacologia , Timo/anatomia & histologia , Animais , Linfócitos B/efeitos dos fármacos , Relação Dose-Resposta a Droga , Feminino , Cobaias , Contagem de Leucócitos , Masculino , Camundongos , Tamanho do Órgão/efeitos dos fármacos , Compostos Orgânicos de Estanho/metabolismo , Ratos , Baço/metabolismo , Linfócitos T/efeitos dos fármacos , Timo/metabolismo
2.
Pharmazie
; 32(10): 558-61, 1977 Oct.
Artigo
em Alemão
| MEDLINE
| ID: mdl-607209