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J Agric Food Chem ; 64(26): 5301-9, 2016 Jul 06.
Artigo em Inglês | MEDLINE | ID: mdl-27248479

RESUMO

Metabolism of chiral pesticides in crops is typically studied using achiral analytical methods and, consequently, the stereoisomer composition of residues is unknown. In this study, we developed an enantioselective GC-MS/MS method to quantify residues of the fungicides fenpropidin, fenpropimorph, and spiroxamine in plant matrices. In field trials, the fungicides were applied to grapevines, sugar beets, or wheat. Fenpropidin was metabolized with no or only weak enantioselectivity. For fenpropimorph, slightly enantioselective metabolism was observed in wheat but more pronounced in sugar beets. This enantioselectivity was due to different rates of metabolism and not due to interconversion of enantiomers. The four stereoisomers of spiroxamine were also metabolized at different rates, but selectivity was only found between diastereomers and not between enantiomers. trans-Spiroxamine was preferentially degraded in grapes and cis-spiroxamine in wheat. These findings may affect the consumer dietary risk assessment because toxicological end points were determined using racemic test substances.


Assuntos
Beta vulgaris/metabolismo , Praguicidas/metabolismo , Compostos de Espiro/metabolismo , Esteróis/biossíntese , Triticum/metabolismo , Vitis/metabolismo , Beta vulgaris/química , Cromatografia Gasosa-Espectrometria de Massas , Praguicidas/química , Compostos de Espiro/química , Estereoisomerismo , Espectrometria de Massas em Tandem , Triticum/química , Vitis/química
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