RESUMO
AIM: We compared post-breakfast closed-loop glucose control either matched with a carbohydrate-matching bolus or a weight-dependent bolus. METHODS: Twelve adults with type 1 diabetes consumed a 75 g CHO breakfast on two occasions. In random order, the breakfast was accompanied by a full carbohydrate-matching insulin bolus (8.30 U [7.50 U-11.50 U]) or a partial weight-dependent insulin bolus (0.047 U/kg; 3.45 U [2.95 U-3.75 U]). Postprandial glucose was regulated by sensor-responsive insulin and glucagon delivery. RESULTS: Glucose control after the weight-dependent bolus was safe and feasible (glucose values returned to pre-prandial levels after 5 h). However, 5-hr incremental area under the curve and percentage of time above 10 mmol/L were lower after the full bolus compared to the partial bolus (IAUC, 2.1 [0.8-4.2] mmol/L/hr vs 8.3 [6.5-11.4] mmol/L/hr; time in hyperglycaemia, 24% [6%-29%] vs 50% [25%-63%]; P < 0.001). CONCLUSIONS: Post-breakfast closed-loop glucose control without carbohydrate counting, but based on weight-dependent bolus is feasible but a carbohydrate-matching bolus provides better glucose control. CLINICAL TRIAL REGISTRY: NCT01519102.
Assuntos
Desjejum , Diabetes Mellitus Tipo 1/tratamento farmacológico , Carboidratos da Dieta/metabolismo , Hiperglicemia/tratamento farmacológico , Hipoglicemiantes/administração & dosagem , Insulina/administração & dosagem , Período Pós-Prandial , Adulto , Algoritmos , Biomarcadores/metabolismo , Glicemia/metabolismo , Canadá , Estudos Cross-Over , Diabetes Mellitus Tipo 1/metabolismo , Esquema de Medicação , Feminino , Humanos , Hiperglicemia/metabolismo , Masculino , Pâncreas Artificial , Resultado do TratamentoRESUMO
This study investigates the relationship between burnout as measured by the Maslach Burnout Inventory and locus of control as measured by the Adult Nowicki-Strickland Internal-External Locus of Control (ANS-IE) for 82 dentists. Significant Pearson correlations between two Maslach subscales and locus of control show Personal Accomplishment to be negatively associated -.31 and Emotional Exhaustion to be positively correlated .21 to externality.
Assuntos
Esgotamento Profissional/psicologia , Odontólogos/psicologia , Controle Interno-Externo , Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inventário de PersonalidadeRESUMO
This study investigated the associations of Locus of Control (Children Nowicki-Strickland Internal-External Control Scale) with state and trait anxiety (State-Trait Anxiety Inventory for Children) in 302 children aged 9 to 12 yr. No significant differences were found between the groups. No significant correlations were found between the anxiety measures and externality for the 31 children from maritally disrupted families, but significant positive Pearson correlations were found for the 271 children of intact families. The results are discussed in terms of the possibility of under-reporting of marital disruption by children.
