RESUMO
A unique separator was developed which allowed automatic separation and peak collection using semi-preparative supercritical fluid chromatography (SFC). A peak detector switched the effluent between waste and special collection cassettes. Up to 50 mg of various solutes were injected onto a 21-mm I.D. Cyano column. The entire flow path was contained and no aerosols were generated. Collection efficiency was as high as 95%. Peak purity was often greater than 99. 9%. Typical run times were less than 10 min. An analytical SFC was used to screen the performance of a wide range of mobile and stationary phases for the elution of more than 60 miscellaneous small drug compounds. The best 'universal' gradient employed 0.4% isobutyl or isopropylamine dissolved in methanol, then mixed from 5 to 55% into carbon dioxide at 10%/min. Flow rate was 50 ml/min. The analytical SFC was shown to be a good predictor of the semi-prep instrumental performance.
Assuntos
Cromatografia/instrumentação , Cromatografia/métodos , Biblioteca de Peptídeos , Ácido 4-Aminobenzoico/química , Antipirina/isolamento & purificação , Benzamidas/química , Butilaminas/química , Dióxido de Carbono/química , Técnicas de Química Combinatória/métodos , Imipramina/isolamento & purificação , Metanol/química , Procaína/isolamento & purificação , Propilaminas/química , Fatores de Tempo , para-AminobenzoatosRESUMO
Recent advances in the evaluation of the amputation stump, the materials that are available for prosthetic application, techniques of improving socket fit, and prosthetic finishings promise to dramatically improve amputee function. Precision casting techniques for providing optimal fit of the amputation stump using materials such as alginate are described. The advantages of transparent check sockets for fitting the complicated amputation stump are described. Advances in research that promise to provide more functional prosthetic feet and faster and more reliable socket molding are the use of CAD-CAM (computer aided design-computer aided manufacturing) and the use of gait analysis techniques to aid in the alignment of the prosthesis after socket fitting. Finishing techniques to provide a more natural appearing prosthesis are described. These advances will gradually spread to the entire prosthetic profession.
Assuntos
Membros Artificiais , Amputação Cirúrgica/reabilitação , Humanos , Perna (Membro)/diagnóstico por imagem , Perna (Membro)/cirurgia , Desenho de Prótese , XerorradiografiaRESUMO
Education costs are causing part-time dental educators to be compensated at inappropriately low levels. By using a deferred compensation plan, the dental school can provide to the part-time educator, a greater return at a time when that money will be of more benefit. Through contractual agreement with the dental school, as drawn up by appropriate financial and legal counsel, a plan can be constructed that can significantly increase the real value of part-time earnings, usually payable at some time in the future, at no additional cost to either the dental school or the part-time dental educator.
