RESUMO
A systematic review of randomized, controlled, prospective clinical studies is described (8 trials; N = 1674 patients), with > 100 patients in each, which evaluated functional outcomes with hylan G-F 20 in secondary analyses. Hylan G-F 20 significantly improved Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) physical function versus appropriate/conventional care or corticosteroid, it significantly improved loss of activity versus saline, and it had similar functional improvements compared with progressive knee exercises or nonsteroidal anti-inflammatory drugs. Functional improvements with hylan G-F 20 also improved with pain relief. Hylan G-F 20 should be considered as part of a multimodal arthritis treatment regimen that focuses on improving function.
Assuntos
Materiais Biocompatíveis/uso terapêutico , Ácido Hialurônico/análogos & derivados , Osteoartrite do Joelho/tratamento farmacológico , Osteoartrite do Joelho/fisiopatologia , Corticosteroides/uso terapêutico , Anti-Inflamatórios não Esteroides/uso terapêutico , Materiais Biocompatíveis/administração & dosagem , Terapia Combinada , Avaliação da Deficiência , Terapia por Exercício , Humanos , Ácido Hialurônico/administração & dosagem , Ácido Hialurônico/uso terapêutico , Injeções Intra-Articulares , Osteoartrite do Joelho/terapia , Dor/tratamento farmacológico , Dor/fisiopatologia , Medição da Dor , Paracentese , Ensaios Clínicos Controlados Aleatórios como Assunto , Resultado do TratamentoRESUMO
A high school tennis player had recurrent ankle sprains that were initially attributed to incomplete rehabilitation. A closer look revealed subtle symptoms of Charcot-Marie-Tooth disease (CMT), a common, inherited neuromuscular disorder. This case underscores the importance of a wide differential diagnosis when encountering recurrent conditions. Early diagnosis of CMT is imperative so that appropriate injury-prevention measures can be taken.
