"Kinetic NMR titration": including chemical shift information in the kinetic analysis of supramolecular reaction systems such as organic replicators.

Efficient harvesting of kinetic and thermodynamic information in supramolecular reaction systems comes from kinetic NMR titration, that is, the combined analysis of NMR integrals and chemical shifts. The method is introduced using a minimal self-replicating system studied at various temperatures.