Effects of exogenous antioxidants on oxidative stress in pregnancy.

OBJECTIVE: The present study evaluated the effects on gestation, in terms of oxidative stress, of two antioxidant factors-vitamin E and coenzyme Q10-during pregnancy, with the purpose of applying the results in further human clinical practice. METHODS: For each aspect we have studied, we used three types of female rats of Wistar race (un-pregnant, primiparous, multiparous), divided in 10 rats/group. From the blood we have sampled, we have determined the oxidative stress (OS) markers: malondialdehyde (MDA) and carbonylated proteins (CP), but also the markers of the antioxidant defense: the hydrogen donor capacity of the plasma (HD) and the sulfhydryl groups (SH). RESULTS: Vitamin E administration determines significant decreases of MDA and significant increases of CP and HD at primiparous, and also significant increases of SH groups at multiparous. In the case of pregnant animals that received CoQ10 in antioxidant complexes, we have observed an increase of oxidative stress (OS)-MDA in primiparous and CP in multiparous. CONCLUSIONS: In the case of Vitamin E, taking into account the benefits on redox homeostasis, the decrease of OS, the authors recommend vitamin E administration during pregnancy. However, because of the increase of the OS in the case of pregnant animals, the authors do not recommend the administration of CoQ(10) in antioxidant complexes during pregnancy.

[The early detection of diabetes mellitus and the active dispensary care of 1200 subjects with a genetic predisposition]. / Depistarea precoce a diabetului zaharat si dispensarizarea activa la 1200 subiecti cu predispozitie genetica.

Diabetes mellitus (DM) is a metabolic disease with a long-lasting chronic course, attending during its development by complications which affect the state of health and require additional measures from the social and economic point of view. The current strategy consists in the earliest possible detection of disease in groups of population selected according to the existent risk of developing a DM. This action is followed by an active dispensary care and by lessons of health education, aimed at preventing metabolic decompensations and the early occurrence of degenerative chronic complications. Taking into account these considerations in the present paper, authors analyse the possibility of detection of DM in 1,200 subjects genetically predisposed, a special stress being laid on the means of prevention, on the role of active dispensary care and on the place of health education in the therapy of DM and in the prevention of complications of this disease with an invalidating potential.