1.
Zh Nevrol Psikhiatr Im S S Korsakova
; 112(3 Pt 1): 39-43, 2012.
Artigo
em Russo
| MEDLINE
| ID: mdl-22677754
RESUMO
We conducted a comparative study on the effect of active compounds of pantogam and pantogam active (calcium D(R)-homopantothenate and calcium DL(RS)-homopantothenate) and its L(S)-isomer on the receptors of main brain neuromediators in rats using in vitro radioligand binding analysis. All three compounds interact with binding sites of specific GABA-A and, in particular, GABA-B receptor ligands. Racemate and S-enantiomer, but not its R-form, competed to a moderate degree for D2-receptor binding sites. In all cases, degrees of interaction with receptors were ranged as follows: S-isomer>racemate>R-isomer. These qualitative and quantitative differences are assumed to contribute to pharmacological activity of both drugs.
Assuntos
Encéfalo/efeitos dos fármacos , Ácido Pantotênico/análogos & derivados , Receptores de Dopamina D2/metabolismo , Receptores de GABA-A/metabolismo , Receptores de GABA-B/metabolismo , Ácido gama-Aminobutírico/análogos & derivados , Animais , Encéfalo/metabolismo , Ácido Pantotênico/química , Ácido Pantotênico/farmacocinética , Ácido Pantotênico/farmacologia , Ensaio Radioligante , Ratos , Estereoisomerismo , Ácido gama-Aminobutírico/química , Ácido gama-Aminobutírico/farmacocinética , Ácido gama-Aminobutírico/farmacologia
2.
Biokhimiia
; 31(5): 881-6, 1966.
Artigo
em Russo
| MEDLINE
| ID: mdl-6001324