[Validation of the early health-resort rehabilitation of patients who have undergone a cholecystectomy]. / Obosnovanie rannei kurortnoi reabilitastsii bol'nykh, perenesshikh kholetsistéktomiiu.

The paper addresses the issue of expediency of early sanatorium treatment of patients with prior cholecystectomy; indications and contraindications are determined as are optimal terms for refferring such patients to specialized departments of gastroenterologic sanatoria in Ukraine. Impact of sanatorium treatment on functional state of the liver and immune system in early periods after cholecystectomy was studied.

[Possibilities of prognostication of complications in duodenal ulcer]. / Vozmozhnosti prognozirovaniia oslozhnenii iazvennoi bolezni dvenadtsatiperstnoi kishki.

The authors investigated a prognostic value (with respect to the complications) of certain laboratory parameters used in the examination of the gastric juice in patients with duodenal ulcer (DU) as well as the prognostic value of certain anamnestic data. A total of 100 patients with DU who had been followed up for 5-6 years were under study. The results obtained demonstrated the most informative values for the DU-related complications turned to be the parameters of the performance of the defense mechanisms of the gastroduodenal area (the contents of mucous proteins, the coefficient of the gastric juice defense), the levels of gastric secretion and acidification (the quantity of the juice, the per hour discharge of hydrochloric acid) as well as the ratio between the coefficient of the defense and the coefficient of the pepsin aggression that reflected the ratio between the aggressive and defensive factors of the gastric juice. Defined discriminant functions permitted the prognostication of complications appearance correct within 80-90%.

[The diagnostic value of the histamine test in studying the gastric juice of patients with duodenal peptic ulcer]. / Diagnosticheskaia tsennost' gistaminovogo testa pri issledovanii zheludochnogo soka bol'nykh iazvennoi bolezn'iu dvenadtsatiperstnoi kishki.

Measurements were made of the content of pepsin and hydrochloric acid in gastric juice from 96 duodenal ulcer patients, obtained under the conditions of basal secretion and after histamine administration in the submaximal dose. The disease was marked by changes in the response to histamine on the part of gastric glands. In duodenal ulcer patients, histamine primarily stimulates pepsin secretion whereas in healthy subjects, secretion of hydrochloric acid is predominant. Based on the regularity thus revealed, a new test (the ratio of the histamine index of pepsin to the histamine index of hydrochloric acid) was developed. This test is of importance for the diagnosis of duodenal ulcer and predicting the gravity of the course it may run.

[The prognostic significance of the protein composition of the gastric juice in peptic ulcer]. / Prognosticheskoe znachenie belkovogo sostava zheludochnogo soka pri iazvennoi bolezni.

A study of 100 patients was done with the purpose of determining the prognostic value of the protein composition and coefficient of defense (ratio of mucus protein composition and coefficient of defense (ratio of mucus protein concentration to proteolytic activity) of the gastric juice and possibility of their use for evaluation of the severity of duodenal ulcer. Results indicate that changes of the protein composition and coefficient of defense of the gastric juice have a prognostic significance for determination of the severity of duodenal ulcer and appearance of complications. Discriminant functions allow to predict the further course of duodenal ulcer with a 70-80% precision.