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1.
Tex Heart Inst J ; 51(1)2024 02 07.
Artigo em Inglês | MEDLINE | ID: mdl-38321789

RESUMO

Erdheim-Chester disease is a rare histiocytosis that primarily affects the skeletal system, but cardiovascular manifestations occur in 75% of cases and are associated with a poor prognosis. Given the small number of cases, the evolution and management of the disease are uncertain. Therefore, it is important to report and share Erdheim-Chester cases. This report presents the case of a young patient with constrictive pericarditis and mitral valve regurgitation resulting from Erdheim-Chester disease.


Assuntos
Doença de Erdheim-Chester , Insuficiência da Valva Mitral , Humanos , Valva Aórtica , Doença de Erdheim-Chester/complicações , Insuficiência da Valva Mitral/complicações , Pericardiectomia
2.
Biomaterials ; 27(17): 3201-8, 2006 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-16497373

RESUMO

This work investigated the impact of implantation sites on the biocompatibility of alginate encapsulated pig islets. Non-diabetic rats were implanted with adult pig islets encapsulated in alginate either intraperitoneally (IP; n=25), subcutaneously (SC; n=37) or under the kidney capsule (KC; n=34). Capsule biocompatibility (retrieval rate, capsule diameter, degree of capsule broken and cellular overgrowth, CD68/CD3 staining) as well as islets viability and functionality were assessed until 30 days after transplantation. Implantation site did not significantly influence the biocompatibility of empty alginate capsules after transplantation (n=48). Most of the empty capsules (>90%) were retrieved after harvesting and were free of cellular overgrowth until day 30 post-transplantation. Three days after implantation, no significant difference for encapsulated pig islets was observed in terms of capsule biocompatibility and islet functionality in peritoneum, KC or subcutaneously. However, between days 5 and 30 after transplantation, explanted capsules from IP demonstrated a higher degree of broken capsules (>13%) and capsules with severe cellular overgrowth (>50%, CD68+ infiltration) than capsules removed from SC and KC (p<0.05). This was associated with a significant reduction of islet viability, insulin content and insulin secretion. In rats, the peritoneum site seems not appropriate for promoting the engraftment of encapsulated pig islets. Kidney subcapsular and subcutaneous spaces represent an interesting alternative.


Assuntos
Alginatos/química , Materiais Biocompatíveis/química , Transplante das Ilhotas Pancreáticas/métodos , Ilhotas Pancreáticas/citologia , Transplante Heterólogo/métodos , Animais , Antígenos CD/biossíntese , Antígenos de Diferenciação Mielomonocítica/biossíntese , Complexo CD3/biossíntese , Sobrevivência Celular , Transplante de Células , Rim/metabolismo , Masculino , Ratos , Ratos Wistar , Suínos , Fatores de Tempo
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