1.
Biochem Biophys Res Commun
; 401(1): 32-6, 2010 Oct 08.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20828540
RESUMO
Hereditary tyrosinemia type 1 is an autosomal recessive metabolic disorder, which is caused by a defective fumarylacetoacetate hydrolase enzyme, and consequently metabolites such as succinylacetone and p-hydroxyphenylpyruvate accumulate. We used a modified comet assay to determine the effect of these metabolites on base- and nucleotide excision repair pathways. Our results indicate that the metabolites affected the repair mechanisms differently, since the metabolites had a bigger detrimental effect on BER than on NER.
Assuntos
Reparo do DNA , Heptanoatos/metabolismo , Ácidos Fenilpirúvicos/metabolismo , Tirosinemias/genética , Tirosinemias/metabolismo , Linhagem Celular , Ensaio Cometa , Humanos , Peróxido de Hidrogênio/toxicidade
2.
S Afr Med J
; 96(9 Pt 2): 854-60, 2006 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17077909