Attitudes towards AI: measurement and associations with personality.

Artificial intelligence (AI) has become an integral part of many contemporary technologies, such as social media platforms, smart devices, and global logistics systems. At the same time, research on the public acceptance of AI shows that many people feel quite apprehensive about the potential of such technologies-an observation that has been connected to both demographic and sociocultural user variables (e.g., age, previous media exposure). Yet, due to divergent and often ad-hoc measurements of AI-related attitudes, the current body of evidence remains inconclusive. Likewise, it is still unclear if attitudes towards AI are also affected by users' personality traits. In response to these research gaps, we offer a two-fold contribution. First, we present a novel, psychologically informed questionnaire (ATTARI-12) that captures attitudes towards AI as a single construct, independent of specific contexts or applications. Having observed good reliability and validity for our new measure across two studies (N1 = 490; N2 = 150), we examine several personality traits-the Big Five, the Dark Triad, and conspiracy mentality-as potential predictors of AI-related attitudes in a third study (N3 = 298). We find that agreeableness and younger age predict a more positive view towards artificially intelligent technology, whereas the susceptibility to conspiracy beliefs connects to a more negative attitude. Our findings are discussed considering potential limitations and future directions for research and practice.

Recognizing the beauty in diversity: Exposure to body-positive content on social media broadens women's concept of ideal body weight.

By depicting an unrealistic share of skinny or toned body types, modern mass media have been found to shift users' perception of an ideal body toward narrow and often unattainable standards. In response to this, the "#bodypositivity" (BoPo) movement on social media has set out to challenge restrictive body ideals, advocating for more open-minded views toward the human physique. Matching BoPo's emphasis on diversity, we hypothesized that viewing body-positive online content alters women's concept of an ideal body to encompass a broader range of body shapes (on a spectrum from skinny to obese). The results of two pre-registered experiments (N1 = 191; N2 = 266) support our assumption, connecting BoPo not only to a larger mean ideal body shape but also to a diversification of weight-related standards. We discuss our work as a crucial extension of prior research, noting that the range found in people's bodily ideals may be (at least) as relevant as their central tendency. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Dysregulated expression and distribution of Kif5α in neurites of wobbler motor neurons.

Impaired axonal transport has been observed in patients with amyotrophic lateral sclerosis (ALS) and in animal models, suggesting that transport proteins likely play a critical role in the pathological mechanism of ALS. Dysregulation of Kinesin-family-member 5α (Kif5α), a neuron-specific isoform of heavy chain kinesin family, has been described in several neurological disorders, in humans and animal models, including ALS. In this study, we determined Kif5α expression by gene sequencing, quantitative reverse transcription-polymerase chain reaction, and western blot assay in the cervical spinal cord of wobbler mice and immunofluorescence staining in dissociated cultures of the ventral horn. Further, we observed the distribution of Kif5α and mitochondria along motor neuronal branches by confocal imaging. Our results showed that Kif5α expression was greatly dysregulated in wobbler mice, which resulted in altered distribution of Kif5α along motor neuronal branches with an abnormal mitochondrial distribution. Thus, our results indicate that dysregulation of Kif5 and therefore abnormal transport in motor neuronal branches in this ALS model could be causative for several pathological findings at the cellular level, like misallocation of cytoskeletal proteins or organelles like mitochondria.

Increased ROS-Dependent Fission of Mitochondria Causes Abnormal Morphology of the Cell Powerhouses in a Murine Model of Amyotrophic Lateral Sclerosis.

Amyotrophic lateral sclerosis (ALS) is the most common motor neuron disease in humans and remains to have a fatal prognosis. Recent studies in animal models and human ALS patients indicate that increased reactive oxygen species (ROS) play an important role in the pathogenesis. Considering previous studies revealing the influence of ROS on mitochondrial physiology, our attention was focused on mitochondria in the murine ALS model, wobbler mouse. The aim of this study was to investigate morphological differences between wild-type and wobbler mitochondria with aid of superresolution structured illumination fluorescence microscopy, TEM, and TEM tomography. To get an insight into mitochondrial dynamics, expression studies of corresponding proteins were performed. Here, we found significantly smaller and degenerated mitochondria in wobbler motor neurons at a stable stage of the disease. Our data suggest a ROS-regulated, Ox-CaMKII-dependent Drp1 activation leading to disrupted fission-fusion balance, resulting in fragmented mitochondria. These changes are associated with numerous impairments, resulting in an overall self-reinforcing decline of motor neurons. In summary, our study provides common pathomechanisms with other ALS models and human ALS cases confirming mitochondria and related dysfunctions as a therapeutic target for the treatment of ALS.

User Responses to a Humanoid Robot Observed in Real Life, Virtual Reality, 3D and 2D.

Humanoid robots (i.e., robots with a human-like body) are projected to be mass marketed in the future in several fields of application. Today, however, user evaluations of humanoid robots are often based on mediated depictions rather than actual observations or interactions with a robot, which holds true not least for scientific user studies. People can be confronted with robots in various modes of presentation, among them (1) 2D videos, (2) 3D, i.e., stereoscopic videos, (3) immersive Virtual Reality (VR), or (4) live on site. A systematic investigation into how such differential modes of presentation influence user perceptions of a robot is still lacking. Thus, the current study systematically compares the effects of different presentation modes with varying immersive potential on user evaluations of a humanoid service robot. Participants (N = 120) observed an interaction between a humanoid service robot and an actor either on 2D or 3D video, via a virtual reality headset (VR) or live. We found support for the expected effect of the presentation mode on perceived immediacy. Effects regarding the degree of human likeness that was attributed to the robot were mixed. The presentation mode had no influence on evaluations in terms of eeriness, likability, and purchase intentions. Implications for empirical research on humanoid robots and practice are discussed.

Synthetic Indolactam V Analogues as Inhibitors of PAR2-Induced Calcium Mobilization in Triple-Negative Breast Cancer Cells.

Human proteinase-activated receptor 2 (PAR2), a transmembrane G-protein-coupled receptor (GPCR), is an attractive target for a novel anticancer therapy, as it plays a critical role in cell migration and invasion. Selective PAR2 inhibitors therefore have potential as anti-metastatic drugs. Knowing that the natural product teleocidin A2 is able to inhibit PAR2 in tumor cells, the goal of the present study was to elaborate structure-activity relationships and to identify potent PAR2 inhibitors with lower activity against the adverse target, protein kinase C (PKC). For this purpose, an efficient gram-scale total synthesis of indolactam V (i.e., the parent structure of all teleocidins) was developed, and a library of derivatives was prepared. Some compounds were indeed found to exhibit high potency as PAR2 inhibitors at low nanomolar concentrations with improved selectivity (relative to teleocidin A2). The pseudopeptidic fragment bridging the C3 and C4 positions of the indole core proved to be essential for target binding, whereas activity and target selectivity depends on the substituents at N1 or C7. This study revealed novel derivatives that show high efficacy in PAR2 antagonism combined with increased selectivity.

Venturing into the uncanny valley of mind-The influence of mind attribution on the acceptance of human-like characters in a virtual reality setting.

For more than 40years, the uncanny valley model has captivated researchers from various fields of expertise. Still, explanations as to why slightly imperfect human-like characters can evoke feelings of eeriness remain the subject of controversy. Many experiments exploring the phenomenon have emphasized specific visual factors in connection to evolutionary psychological theories or an underlying categorization conflict. More recently, studies have also shifted away focus from the appearance of human-like entities, instead exploring their mental capabilities as basis for observers' discomfort. In order to advance this perspective, we introduced 92 participants to a virtual reality (VR) chat program and presented them with two digital characters engaged in an emotional and empathic dialogue. Using the same pre-recorded 3D scene, we manipulated the perceived control type of the depicted characters (human-controlled avatars vs. computer-controlled agents), as well as their alleged level of autonomy (scripted vs. self-directed actions). Statistical analyses revealed that participants experienced significantly stronger eeriness if they perceived the empathic characters to be autonomous artificial intelligences. As human likeness and attractiveness ratings did not result in significant group differences, we present our results as evidence for an "uncanny valley of mind" that relies on the attribution of emotions and social cognition to non-human entities. A possible relationship to the philosophy of anthropocentrism and its "threat to human distinctiveness" concept is discussed.