[Secretion of inflammatory cytokines and prostaglandins by fetal trophoblast cells induces uterine contraction and labor onset]. / Die Sekretion inflammatorischer Zytokine bzw. Prostaglandine durch fetale Trophoblastzellen induziert Wehentätigkeit und Geburtsbeginn.

OBJECTIVE: Induce infection-associated cytokines intrauterine secretion of prostaglandins and term labor? METHODS: Concentrations of Il-6, Il-1 beta, TNF-alpha, PGF2 and PGF2 alpha were determined in cervical secretions and amniotic fluid during spontaneous term labor. The supernatant of amnion-, chorion-, decidua- and trophoblast cells, cultured after elective cesarean section or spontaneous delivery, was analysed for cytokine- and prostaglandin activity. RESULTS: Term labor always is associated with intrauterine cytokine- and prostaglandin release. Increased production of cytokines and prostaglandins in case of normal term labor only was found by fetal trophoblast cells. CONCLUSIONS: Signal for parturition is of trophoblast and therefore of fetal origin.