Assuntos
Técnicas Bacteriológicas , Coleta de Amostras Sanguíneas , Agulhas , Sangue , Meios de Cultura , HumanosAssuntos
Alopurinol/efeitos adversos , Arterite/induzido quimicamente , Coformicina/efeitos adversos , Hipersensibilidade a Drogas/etiologia , Ribonucleosídeos/efeitos adversos , Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/secundário , Idoso , Coformicina/análogos & derivados , Humanos , Neoplasias Pulmonares/tratamento farmacológico , Neoplasias Pulmonares/secundário , Masculino , Necrose , PentostatinaRESUMO
A neonate who died 12 days after birth from complications related to a congenital neuroblastoma is described. Hypertension and congestive heart failure occurred soon after birth. Hospital course was marked by a consumptive coagulopathy and the development of acute renal and hepatic failure. At autopsy the heart was hypertrophied but normally formed. Although there was elevated urinary excretion of vanilmandelic acid and homovanillic acid, levels of epinephrine, norepinephrine, metanephrine, and normetanephrine were not documented. This case shows that a congenital neuroblastoma may be associated with hypertension and cardiomegaly in the neonatal period.
Assuntos
Cardiomegalia/complicações , Hipertensão Pulmonar/complicações , Neuroblastoma/complicações , Catecolaminas/urina , Insuficiência Cardíaca/complicações , Humanos , Hipertensão Pulmonar/urina , Lactente , Recém-Nascido , Neuroblastoma/congênito , Neuroblastoma/patologia , Neoplasias Retroperitoneais/complicações , Neoplasias Retroperitoneais/congênito , Neoplasias Retroperitoneais/patologiaRESUMO
The case of a 15-year-old white boy with a clinical diagnosis of von Recklinghausen neurofibromatosis and a history of multiple fractures of long bones is presented. Radiographic studies and tissue biopsy revealed the presence of multiple nonossifying fibromas of bone. Review of the clinical features and correlation with the pathologic data support a diagnosis of Jaffe-Campanacci syndrome, a malformation syndrome different from but possibly related to von Recklinghausen neurofibromatosis.
Assuntos
Neoplasias Ósseas/patologia , Fibroma/patologia , Transtornos da Pigmentação/patologia , Adolescente , Neoplasias Ósseas/diagnóstico por imagem , Diagnóstico Diferencial , Fibroma/diagnóstico por imagem , Humanos , Masculino , Neurofibromatose 1/patologia , Radiografia , SíndromeRESUMO
Ibuprofen is a non-steroidal anti-inflammatory agent which is relatively safe and effective for the treatment of inflammatory disorders, but there are several reports of acute poisoning due to ibuprofen overdosage. Although the majority of ibuprofen overdosages are not very serious, acute renal failure, hepatic failure, and hypotension and coma have been described. We report here the case of a 48-year-old male who committed suicide by ingesting overdosages of both ibuprofen and acetaminophen. The case is unique because of the role ibuprofen played in his death, and because we were able to measure levels of ibuprofen in tissues obtained from post mortem examination. Tissue levels of ibuprofen have not previously been reported in humans.