RESUMO
The results were evaluated of cytological and histological examination of 215 bone biopsies taken with an electric minidrill in 211 patients with suspected malignancies in bones. 171 biopsies were taken in 167 patients with a known malignancy. In 78 cases a malignancy was demonstrated including 4 cases of a second primary malignancy. 44 biopsies of patients without a known primary malignancy resulted in 19 cases of malignancy, mainly metastatic disease. There were no primary bone tumours. Follow-up showed a false negative result in 5 patients, all with known primary malignancies. Follow-up of the patients without known malignancies showed no false negatives. The sensitivity of cytology alone was 92% and the sensitivity of histology alone was 76%. The combination of cytology and histology resulted in a sensitivity of 95%. The specificity of the procedure was 100%.
Assuntos
Biópsia/métodos , Neoplasias Ósseas/patologia , Osso e Ossos/patologia , Biópsia/instrumentação , Reações Falso-Negativas , Humanos , Equipamentos Ortopédicos , Estudos Retrospectivos , Sensibilidade e EspecificidadeRESUMO
The effects of single-donor (SD) and multiple-donor (MD) platelet transfusions in 34 cancer patients with severe thrombocytopenia and haemorrhages were compared in a randomised study. Platelet recovery values in both groups were similar after the first transfusion. After the second transfusion platelet recovery values were significantly better in those receiving SD transfusions. Platelet recovery values gradually declined with subsequent MD transfusions. These results suggest early alloimmunisation in the MD transfused patients only. MD transfusions were estimated to be no longer effective after about nine transfusions. Platelet recovery values were better indicators of early sensitisation than was the lymphocytotoxicity test. Restriction of the number of donors per transfusion may postpone the development of refractoriness to random-donor platelet transfusions in thrombocytopenic patients.
