[Humoral link of autoimmune reactions to neuron-specific enolase in post-radiation encephalopathy patients]. / Doslidzhennia humoral'noï lanki autoimunnykh reaktsii do neirospetsyfichnoï ienolazy u khvorykh na postradiatsiinu entsefalopatiiu.

The purpose of this research was to study the humoral link of autoimmune response to the brain antigen i.e. neurospecific enolase (NSE) in liquidators of the Chernobyl accident aftereffects diagnosed as having "postradiation encephalopathy" (PREP). Determined in the PREP patients' serum were: NSE content, level of autoantibodies to NSE, concentration and size of the immune complexes (IC) as well as NSE content in the IC. The majority of PREP patients revealed high serum level of NSE and high level of autoantibodies to NSE. Concentration of small and middle-size IC was 2-3 times higher than normal. So the presence of circulating NSE and autoantibodies thereto in the liquidators' blood serum evidences of an organic lesion of the brain neurons, this causing the development of neurological syndromes. It is likely that at certain stages of the PREP pathogenesis there appear autoimmune responses to neuroantigens which prove the destructive effects of radiation on the CNS. Probably, in patients with PREP 2-3 degrees the autoimmune processes become chronic due to pathogenic action of free autoantibodies to NSE and of small NSE-anti-NSE complexes which are known to be the most pathogenic and capable of being fixed on complementary brain structures promoting their damage.

[The effect of the combined treatment of patients with postradiation encephalopathy on lipid peroxidation activity]. / Vplyv kompleksnoho likuvannia khvorykh z postradiatsiinoiu entsefalopatiieiu na aktyvnist' perekysnoho okyslennia lipidiv.

Conventionally healthy persons-donors and diseased subjects who had taken part in the elimination of the Chernobyl accident effects were evaluated for the activity of the process of free radical lipid peroxidation (LPO). The patient population demonstrated a significant elevation of blood levels of malonic dialdehyde, enhancement of intensity of spontaneous chemoluminescence together with a decrease in resistance of red cells to oxide. After the general course of therapy involving use of enterosorbents, antioxidants, and normobaric intermittent hypoxia, there was an appreciable decrease in the blood plasma LPO intensity, which observation was accompanied with improvement in general health of the patients.

[Rehabilitative treatment in functional disorder of the oculomotor nerve in patients with intracranial arterial aneurysm]. / Vosstanovitel'noe lechenie pri narushenii funktsii glazodvigatel'nogo nerva u bol'nykh s vnutricherepnymi arterial'nymi anevrizmami.

Data are reported by the authors on electric stimulation of the oculomotor muscles in 26 patients who underwent the operation of endovascular occlusion of saccular aneurysms of the supraclinoid portion of the internal carotid artery. This method of rehabilitation treatment proved effective and is recommended for wider use.