Cancer-preventive activities of secondary metabolites from leaves of the bilberry Vaccinium smallii A. Gray.

Ten secondary metabolites including flavonoids (1-8), caffeic (9) and chlorogenic (10) acids were structurally identified from the extract of Sakhalin bilberry Vaccinium smallii leaves and studied in vitro as potential cancer-preventive agents. The results showed that compounds 1-10 inhibited EGF-induced neoplastic transformation of mouse JB6 Cl 41 P+ cells in soft agar with an inhibition concentration (INCC50) of 20-80 µm. Moreover, all these natural products were non-toxic against JB6 Cl 41 P+ cells up to a concentration of 200 µm.

[Rehabilitation of patients with acute uncomplicated myocardial infarct according to 3 1/2-week program]. / Opyt rehabilitatsii bol'nykh ostrym neoslozhnennym infarktom miokarda po 3 1/2-nedel'noi programme

The study was conducted in 220 patients with uncomplicated localized primary myocardial infarction, aged 30 to 65 years, rehabilitated according to the 3 1/2-week programme. The control group was composed of 110 patients rehabilitated according to the 5-week programme. At the hospital stage of rehabilitation it has been established that the contractile activity of the myocardium is the same in both groups of patients and is characterized by hypodynamia. On this basis it was concluded that further physical rehabilitation of these patients should be conducted at a moderate pace with an obligatory control of exercise tolerance. The dynamic observation 1--2 years after myocardial infarction has demonstrated that the physical capacity for work is higher among the patients rehabilitated according to the 3 1/2-week programme, than among the control group patients. The 3 1/2-week rehabilitation does not increase the number of complications, either in the acute period of the disease, or 1--2 years after it. This permits to recommend the 3 1/2-week rehabilitation programme for the patients with acute uncomplicated primary infarction.