[Changes in lipid fractions of blood during the treatment of hypertension with prazosin and trasicor]. / Sdvigi fraktsii lipidov krovi pri korrektsii arterial'no'i gipertenzii prazozinom i trazikorom.

The paper deals with the study into the benefits of prazosin and trasicor used in arterial hypertension. Their effects on the blood lipid composition were evaluated. With prazosin, the steady antihypertensive effect was reached in 81.0%, whereas with trasicor, it was attained in 46%. When prazosin was given, total cholesterol and triglycerides were statistically significantly decreased by 6.8 and 14.8%, respectively, while high density lipoproteins was increased by 9.1%. When trasicor was administered, no changes were observed in the spectrum of serum lipids. Thus, prazosin is effective in correcting two major risk factors for coronary heart disease, namely arterial hypertension and hyperlipoproteinemia, thereby reducing a risk for coronary heart disease.

[Direct recording of electrical activity of human sinoatrial node]. / Priamaia registratsiia élektricheskoi aktivnosti sinoatrial'nogo uzla u cheloveka.

The authors developed a method for recording the electrical activity directly from the human sinus node through the right subclavian vein. Electrical activity of the sinoatrial node (SA) was studied in 179 patients with CHD (angina pectoris, myocardial infarction). The sick-sinus syndrome (SSS) was revealed in 86 patients. The duration of slow deflection Sd, Ss -- P interval (from the onset of Ss to the onset of P wave), P -- A1 interval (from the onset of P wave to the first atrial spike) was prolonged in cases with SSS. The duration of Sd, Ss -- P and P -- A1 decreased after nitroglycerine and atropine administration but increased after benzodixin administration. The data on direct pacing of the SA node and the changes in the duration of phase Sd and Ss after the administration of drugs confirm that slow deflection Sd and rapid preatrial deflection Ss reflect the electrical activity of the SA node.