Universal ichthyosiform trichophyton violaceum in myxoedema.

In a man aged 29 following thyroidectomy complicated by myxoedema an onychomycotic infection of long duration spread suddenly and fast onto the skin. A serious traffic accident coincided with the insidious onset of myxoedema. The patient was very irregular in taking medicines and continuously on sick pay. Myxoedema worsened and the ringworm progressed into a generalized ichthyosiform--universal mycotic--condition.

Acrokerato - Elastoidosis Lineaius Manus.

A Variant of acrokerato elastoidosis characterized by linear, scaly, hyperkeratotic, fissured and transluscent papules on sides of thumbs and index fingers, was seen in 55 male patients, above the age, of fifty years. Actinic damage and repeated trauma were not evident. The term acrokerato - elastodosis linearis manus is suggested for this variant.

A separation of clinical from epidermal thinning effect in the topical glucocorticoid clobetasone butyrate.

Clobetasone butyrate ointment has been shown to be more effective in treating psoriasis and eczema than flurandrenolone ointment yet to cause less epidermal thinning in a human experimental model. This is an indication that the clinical activity of topical glucocorticoids may not necessarily be inseparable from their propensity to cause atrophy of the skin.

Elastotic degeneration. A light and electron microscopic study.

The formation of elastotic material in the dermis of the exposed skin of elderly persons, and of two younger patients with manifestations of precocious degeneration, was studied by light and by electron microscopy. Initially fine filaments or apparently granular material, or both, appeared around collagen fibres, which were mildly altered. On the exposed sites there was gradual loss of matrix and striation of the collagen forming an amorphous substance in which scattered, optically dense material appeared. Several appearances were common to all subjects.