RESUMO
In 1930 Gilbert Brown was prominent in the South Australian Branch of the British Medical Association and instrumental in the establishment of a Section of Anaesthetics. He was elected the first President of this scientifically and academically orientated section. He became the first President of the Australian Society of Anaesthetists from 1934-1939. He is commemorated by the Society in the Gilbert Brown Award for major contribution to a subject or event of the Society. The Australian and New Zealand College of Anaesthetists awards the Gilbert Brown Prize to the contributor judged to have made the best contribution at each Annual Scientific Meeting.
Assuntos
Anestesiologia/história , Austrália , História do Século XXRESUMO
Metabolism of halothane was studied in nine children receiving daily halothane anaesthetics (from 10 up to a maximum of 31) over periods of two to seven weeks. Serum bromide concentrations never exceeded 3.5 mmol/l, a concentration below the toxic threshold. Repeated halothane anaesthetics at short intervals did not induce the reductive metabolism of halothane as assessed by 2-chloro-1,1,1-trifluoroethane (CTF) in the expired breath. One patient developed viral hepatitis A during the course of anaesthetic administration; this patient was the only one whose serum bromide concentrations fell substantially and whose exhaled CTF concentration increased as more anaesthetics were administered.
Assuntos
Anestesia por Inalação , Halotano/metabolismo , Adulto , Brometos/sangue , Criança , Feminino , Halotano/análogos & derivados , Halotano/sangue , Humanos , Testes de Função Hepática , Masculino , Fatores de TempoRESUMO
Tracheal aspirates from 46 children were examined for the presence of fat-filled macrophages. They had no history suggestive of gastro-oesophageal reflux. The number of positive results from this group (46%) was compared with the number of positive results (73%) in a group of 40 children with proven gastro-oesophageal reflux. The difference in proportion of positive results between the two groups was statistically significant (P less than 0.05). In addition, subgroups of subjects, negative for gastro-oesophageal reflux and lower respiratory tract disease, were compared with children who had both conditions. A slightly greater difference, although at a similar level of significance, was found. The fact that 42% of subjects without lower respiratory tract disease or gastro-oesophageal reflux had tracheal aspirates positive for fat-filled macrophages would, however, suggest that this test is of limited clinical value and may need better quantitation before it can be recommended for widespread clinical use.
Assuntos
Refluxo Gastroesofágico/diagnóstico , Macrófagos/análise , Doenças Respiratórias/diagnóstico , Criança , Pré-Escolar , Feminino , Refluxo Gastroesofágico/complicações , Humanos , Masculino , Doenças Respiratórias/etiologia , Traqueia/citologiaRESUMO
A 7-week-old boy presented with symptoms and signs characteristic of infant botulism, and the diagnosis was confirmed by the detection of Clostridium botulinum type A organisms and toxin in the feces. The levels of organisms and toxin in the feces were measured throughout the 81-day period in hospital. The maximum levels detected were 2.46 x 10(8) C. botulinum type A colony-forming units and 64,000 mouse 100% lethal doses of type A toxin per g (wet weight) of feces. C. botulinum toxin was also detected in two samples of the patient's serum, collected 3 and 10 days after admission. Improvement in the patient's clinical condition occurred before the levels of organisms and toxin in the feces reached their maxima. A slight improvement may also have occurred while toxin was still present in the serum.
