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1.
Cereb Cortex ; 29(10): 4321-4333, 2019 09 13.
Artigo em Inglês | MEDLINE | ID: mdl-30561529

RESUMO

Blindness early in life induces permanent alterations in brain anatomy, including reduced surface area of primary visual cortex (V1). Bilateral enucleation early in development causes greater reductions in primary visual cortex surface area than at later times. However, the time at which cortical surface area expansion is no longer sensitive to enucleation is not clearly established, despite being an important milestone for cortical development. Using histological and MRI techniques, we investigated how reductions in the surface area of V1 depends on the timing of blindness onset in rats, ferrets and humans. To compare data across species, we translated ages of all species to a common neuro-developmental event-time (ET) scale. Consistently, blindness during early cortical expansion induced large (~40%) reductions in V1 surface area, in rats and ferrets, while blindness occurring later had diminishing effects. Longitudinal measurements on ferrets confirmed that early enucleation disrupted cortical expansion, rather than inducing enhanced pruning. We modeled the ET associated with the conclusion of the effect of blindness on surface area at maturity (ETc), relative to the normal conclusion of visual cortex surface area expansion, (ETdev). A final analysis combining our data with extant published data confirmed that ETc occurred well before ETdev.


Assuntos
Cegueira/patologia , Cegueira/fisiopatologia , Furões/anatomia & histologia , Furões/crescimento & desenvolvimento , Privação Sensorial/fisiologia , Córtex Visual/crescimento & desenvolvimento , Córtex Visual/patologia , Idade de Início , Animais , Córtex Cerebral/crescimento & desenvolvimento , Córtex Cerebral/patologia , Humanos , Ratos , Especificidade da Espécie
2.
Brain Topogr ; 31(4): 690-699, 2018 07.
Artigo em Inglês | MEDLINE | ID: mdl-29464519

RESUMO

Langguth et al. (2006) described a method for targeting primary auditory cortex (PAC) during transcranial magnetic stimulation (TMS) using the 10-20 electroencephalography system. Study aims were to measure the degree of accuracy in placing the TMS coil on the scalp overlying PAC using the 10-20 method and determine the extent to which accuracy depends on the hemisphere of the coil placement. Twelve participants underwent anatomical magnetic resonance imaging (MRI) of their head in a 3T scanner. Before imaging, a fiducial marker was placed on their scalp corresponding to the TMS coil position. MRI scans were analyzed to determine the distance from the fiducial marker to PAC for each participant. On average, the 10-20 method resulted in distances in the medial-lateral, anterior-posterior, and inferior-superior dimensions that were within a few millimeters (~ 4 mm) of each other between the left and right hemispheres. The fiducial marker was, on average, 10.4 mm superior and 10.8 mm posterior to the optimal scalp location that minimized the distance to PAC. Individual asymmetries and other systematic differences found in this study raise important considerations to keep in mind that might necessitate using an MRI-guided method of coil-positioning when targeting PAC for TMS.


Assuntos
Córtex Auditivo/diagnóstico por imagem , Zumbido/terapia , Estimulação Magnética Transcraniana/métodos , Adulto , Idoso , Eletroencefalografia , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Zumbido/diagnóstico por imagem
3.
Cereb Cortex ; 27(8): 3970-3979, 2017 08 01.
Artigo em Inglês | MEDLINE | ID: mdl-27422412

RESUMO

Current research in connectomics highlights that self-organized functional networks or "communities" of cortical areas can be detected in the adult brain. This perspective may provide clues to mechanisms of treatment response in psychiatric conditions. Here we examine functional brain community topology based on resting-state fMRI in adult Attention-Deficit/Hyperactivity Disorder (ADHD; n = 22) and controls (n = 31). We sought to evaluate ADHD patterns in adulthood and their modification by short term stimulants administration. Participants with ADHD were scanned one or two weeks apart, once with medication and once without; comparison participants were scanned at one time-point. Functional connectivity was estimated from these scans and community detection applied to determine cortical network topology. Measures of change in connectivity profile were calculated via a graph measure, termed the Node Dissociation Index (NDI). Compared to controls, several cortical networks had atypical connectivity in adults with ADHD when withholding stimulants, as measured by NDI. In most networks stimulants significantly reduced, but did not eliminate, differences in the distribution of connections between key brain systems relative to the control sample. These findings provide an enriched model of connectivity in ADHD and demonstrate how stimulants may exert functional effects by altering connectivity profiles in the brain.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/tratamento farmacológico , Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia , Encéfalo/efeitos dos fármacos , Encéfalo/fisiopatologia , Estimulantes do Sistema Nervoso Central/uso terapêutico , Adolescente , Adulto , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico por imagem , Encéfalo/diagnóstico por imagem , Estudos de Coortes , Conectoma , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Vias Neurais/diagnóstico por imagem , Vias Neurais/efeitos dos fármacos , Vias Neurais/fisiopatologia , Escalas de Graduação Psiquiátrica , Descanso , Resultado do Tratamento , Adulto Jovem
4.
J Int Neuropsychol Soc ; 18(3): 511-20, 2012 May.
Artigo em Inglês | MEDLINE | ID: mdl-22433515

RESUMO

Difficulty with selective attention is a frequent complaint of adult patients with ADHD, but selective attention tasks have not provided robust evidence of attentional dysfunction in this group. Two experiments examine this puzzle by distinguishing between failures of spatial selection and problems due to sensitivity to perceptual interference. In Experiment 1, we measured the level of perceptual interference generated by targets in crowded displays with nearby distractors by comparing luminance thresholds in both distractor-present (noise) and distractor-absent (clean) displays. ADHD and control participants had comparable thresholds for clean displays, but ADHD individuals had elevated thresholds to crowded displays. These effects could be explained in two distinct ways. Deficits may have arisen from amplified visual interference in the noise condition, or from abnormalities in top-down attentional processes that reduce visual interference. Experiment 2 adjusted for individual perceptual differences with clean and noise displays, before measuring visual interference resolution at attended versus unattended locations. ADHD and control groups had comparable interference resolution at attended locations. These results suggest that perceptual interference rather than spatial attention deficits may account for some deficits in ADHD. This putative deficit in sensory function highlights a potential early-stage perceptual processing deficit in ADHD distinct from selective attention.


Assuntos
Transtorno do Deficit de Atenção com Hiperatividade/fisiopatologia , Atenção/fisiologia , Mascaramento Perceptivo/fisiologia , Percepção Visual/fisiologia , Logro , Adolescente , Adulto , Transtorno do Deficit de Atenção com Hiperatividade/diagnóstico , Sinais (Psicologia) , Feminino , Humanos , Inteligência , Masculino , Testes Neuropsicológicos , Estimulação Luminosa , Adulto Jovem
5.
PLoS One ; 7(1): e30468, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-22276205

RESUMO

BACKGROUND: Cognitive abilities, such as working memory, differ among people; however, individuals also vary in their own day-to-day cognitive performance. One potential source of cognitive variability may be fluctuations in the functional organization of neural systems. The degree to which the organization of these functional networks is optimized may relate to the effective cognitive functioning of the individual. Here we specifically examine how changes in the organization of large-scale networks measured via resting state functional connectivity MRI and graph theory track changes in working memory capacity. METHODOLOGY/PRINCIPAL FINDINGS: Twenty-two participants performed a test of working memory capacity and then underwent resting-state fMRI. Seventeen subjects repeated the protocol three weeks later. We applied graph theoretic techniques to measure network organization on 34 brain regions of interest (ROI). Network modularity, which measures the level of integration and segregation across sub-networks, and small-worldness, which measures global network connection efficiency, both predicted individual differences in memory capacity; however, only modularity predicted intra-individual variation across the two sessions. Partial correlations controlling for the component of working memory that was stable across sessions revealed that modularity was almost entirely associated with the variability of working memory at each session. Analyses of specific sub-networks and individual circuits were unable to consistently account for working memory capacity variability. CONCLUSIONS/SIGNIFICANCE: The results suggest that the intrinsic functional organization of an a priori defined cognitive control network measured at rest provides substantial information about actual cognitive performance. The association of network modularity to the variability in an individual's working memory capacity suggests that the organization of this network into high connectivity within modules and sparse connections between modules may reflect effective signaling across brain regions, perhaps through the modulation of signal or the suppression of the propagation of noise.


Assuntos
Encéfalo/anatomia & histologia , Encéfalo/fisiologia , Memória de Curto Prazo/fisiologia , Adulto , Mapeamento Encefálico , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Adulto Jovem
6.
Proc Natl Acad Sci U S A ; 108(27): 11241-5, 2011 Jul 05.
Artigo em Inglês | MEDLINE | ID: mdl-21709236

RESUMO

Teenagers are often impulsive. In some cases this is a phase of normal development; in other cases impulsivity contributes to criminal behavior. Using functional magnetic resonance imaging, we examined resting-state functional connectivity among brain systems and behavioral measures of impulsivity in 107 juveniles incarcerated in a high-security facility. In less-impulsive juveniles and normal controls, motor planning regions were correlated with brain networks associated with spatial attention and executive control. In more-impulsive juveniles, these same regions correlated with the default-mode network, a constellation of brain areas associated with spontaneous, unconstrained, self-referential cognition. The strength of these brain-behavior relationships was sufficient to predict impulsivity scores at the individual level. Our data suggest that increased functional connectivity of motor-planning regions with networks subserving unconstrained, self-referential cognition, rather than those subserving executive control, heightens the predisposition to impulsive behavior in juvenile offenders. To further explore the relationship between impulsivity and neural development, we studied functional connectivity in the same motor-planning regions in 95 typically developing individuals across a wide age span. The change in functional connectivity with age mirrored that of impulsivity: younger subjects tended to exhibit functional connectivity similar to the more-impulsive incarcerated juveniles, whereas older subjects exhibited a less-impulsive pattern. This observation suggests that impulsivity in the offender population is a consequence of a delay in typical development, rather than a distinct abnormality.


Assuntos
Comportamento do Adolescente/fisiologia , Criminosos/psicologia , Comportamento Impulsivo/fisiopatologia , Adolescente , Comportamento do Adolescente/psicologia , Algoritmos , Atenção/fisiologia , Encéfalo/crescimento & desenvolvimento , Encéfalo/fisiopatologia , Função Executiva/fisiologia , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Modelos Neurológicos , Córtex Motor/crescimento & desenvolvimento , Córtex Motor/fisiopatologia , Rede Nervosa/fisiopatologia , Prisioneiros/psicologia , Adulto Jovem
7.
Neurobiol Aging ; 32(9): 1634-50, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-19913944

RESUMO

Several recent studies have documented age-related changes in brain activity--less amygdala activity and higher prefrontal activity in response to emotional stimuli. Using functional magnetic resonance imaging (fMRI), we examined whether aging also affects the maintenance of activity to emotional stimuli and whether maintenance differs by the valence (negative, neutral and positive) of the pictures. Younger participants had a larger volume of activity in the amygdala but less in the prefrontal cortex than the old. The old showed more habituation to highly arousing negative but not positive or neutral stimuli in prefrontal cortex as compared to younger participants. Thus prefrontal cortex activity indexes emotion in the elderly, but not the young. Amplified prefrontal activity suggests elderly increase cognitive control for negative, highly arousing emotional stimuli, but it is not maintained. Taken together, age-related increases in prefrontal activity and reduced amygdala activity may underlie observed affective changes in aging.


Assuntos
Envelhecimento/fisiologia , Tonsila do Cerebelo/fisiologia , Emoções/fisiologia , Habituação Psicofisiológica/fisiologia , Córtex Pré-Frontal/fisiologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Envelhecimento/psicologia , Feminino , Humanos , Masculino , Adulto Jovem
8.
Front Syst Neurosci ; 4: 10, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20514143

RESUMO

Recent years have witnessed a surge of investigations examining functional brain organization using resting-state functional connectivity MRI (rs-fcMRI). To date, this method has been used to examine systems organization in typical and atypical developing populations. While the majority of these investigations have focused on cortical-cortical interactions, cortical-subcortical interactions also mature into adulthood. Innovative work by Zhang et al. (2008) in adults have identified methods that utilize rs-fcMRI and known thalamo-cortical topographic segregation to identify functional boundaries in the thalamus that are remarkably similar to known thalamic nuclear grouping. However, despite thalamic nuclei being well formed early in development, the developmental trajectory of functional thalamo-cortical relations remains unexplored. Thalamic maps generated by rs-fcMRI are based on functional relationships, and should modify with the dynamic thalamo-cortical changes that occur throughout maturation. To examine this possibility, we employed a strategy as previously described by Zhang et al. to a sample of healthy children, adolescents, and adults. We found strengthening functional connectivity of the cortex with dorsal/anterior subdivisions of the thalamus, with greater connectivity observed in adults versus children. Temporal lobe connectivity with ventral/midline/posterior subdivisions of the thalamus weakened with age. Changes in sensory and motor thalamo-cortical interactions were also identified but were limited. These findings are consistent with known anatomical and physiological cortical-subcortical changes over development. The methods and developmental context provided here will be important for understanding how cortical-subcortical interactions relate to models of typically developing behavior and developmental neuropsychiatric disorders.

9.
Behav Brain Res ; 196(1): 134-8, 2009 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-18805443

RESUMO

We used functional magnetic resonance imaging (fMRI) to examine responses within auditory cortical fields during the passive listening of pure tone (PT) and frequency modulated (FM) stimuli in seven early blind (EB), five late blind (LB) and six sighted control (SC) individuals. Subjects were scanned using a "sparse sampling" imaging technique while listening to PT and FM sounds presented at either low (400 Hz) or high (4 kHz) center frequencies. When high tones were directly compared to low tones, the resulting activation maps showed a general tonotopic organization within the superior and middle temporal lobes at statistically significant thresholds for the SC and LB groups while the EB group showed a comparable tonotopic organization but only at statistically non-significance thresholds. A contrast of all tonal stimuli to a quiet baseline similarly revealed significantly less signal volume in the EB than in either the LB or SC groups. These results suggest that EB does not alter inherent patterns of tonotopic organization but rather, under low-demand listening conditions, results in a more efficient processing of simple auditory stimuli within the early stages of the auditory hierarchy. While these effects must be interpreted cautiously due to the small sample sizes, they indicate that functional responses in auditory cortical areas are altered by visual deprivation and that intramodal auditory plasticity may underlie previously reported auditory advantages observed in the blind.


Assuntos
Córtex Auditivo/fisiopatologia , Percepção Auditiva/fisiologia , Cegueira/fisiopatologia , Aprendizagem por Discriminação/fisiologia , Estimulação Acústica/métodos , Adulto , Audiometria de Tons Puros/métodos , Córtex Auditivo/patologia , Cegueira/psicologia , Encéfalo/patologia , Encéfalo/fisiopatologia , Feminino , Lateralidade Funcional/fisiologia , Audição/fisiologia , Humanos , Percepção Sonora/fisiologia , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Percepção da Altura Sonora/fisiologia , Lobo Temporal/patologia , Lobo Temporal/fisiopatologia , Fatores de Tempo , Adulto Jovem
10.
Psychopharmacology (Berl) ; 201(2): 183-93, 2008 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-18685833

RESUMO

BACKGROUND: Methamphetamine (MA)-dependent individuals prefer smaller immediate over larger delayed rewards in delay discounting (DD) tasks. Human and animal data implicate ventral (amygdala, ventral striatum, ventrolateral prefrontal cortex insula) and dorsal (dorsolateral prefrontal cortex, dorsal anterior cingulate cortex and posterior parietal cortex) systems in DD decisions. The ventral system is hypothesized to respond to the salience and immediacy of rewards while the dorsal system is implicated in the process of comparison and choice. METHODS: We used functional Magnetic Resonance Imaging to probe the neural correlates of DD in 19 recently abstinent MA-dependent patients and 17 age- and gender-matched controls. RESULTS: Hard DD choices were associated with greatest activation in bilateral middle cingulate, posterior parietal cortex (PPC), and the right rostral insula. Control subjects showed more activation than MA patients bilaterally in the precuneus and in the right caudate nucleus, anterior cingulate cortex (ACC), and dorsolateral prefrontal cortex (DLPFC). Magnitude of discounting was correlated with activity in the amygdala, DLPFC, posterior cingulate cortex and PPC. CONCLUSIONS: Our findings were consistent with a model wherein dorsal cognitive systems modulate the neural response of ventral regions. Patients addicted to MA, who strongly prefer smaller immediate over larger delayed rewards, activate the dorsal cognitive control system in order to overcome their preference. Activation of the amygdala during choice of delayed rewards was associated with a greater degree of discounting, suggesting that heavily discounting MA-dependent individuals may be more responsive to the negative salience of delayed rewards than controls.


Assuntos
Transtornos Relacionados ao Uso de Anfetaminas/diagnóstico , Comportamento Aditivo/diagnóstico , Comportamento de Escolha/fisiologia , Córtex Pré-Frontal/fisiologia , Adulto , Transtornos Relacionados ao Uso de Anfetaminas/psicologia , Tonsila do Cerebelo/anatomia & histologia , Tonsila do Cerebelo/efeitos dos fármacos , Tonsila do Cerebelo/fisiologia , Comportamento Aditivo/induzido quimicamente , Comportamento Aditivo/psicologia , Comportamento de Escolha/efeitos dos fármacos , Interpretação Estatística de Dados , Feminino , Giro do Cíngulo/anatomia & histologia , Giro do Cíngulo/efeitos dos fármacos , Giro do Cíngulo/fisiologia , Humanos , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Modelos Anatômicos , Lobo Parietal/anatomia & histologia , Lobo Parietal/efeitos dos fármacos , Lobo Parietal/fisiologia , Córtex Pré-Frontal/anatomia & histologia , Córtex Pré-Frontal/efeitos dos fármacos
11.
Psychon Bull Rev ; 15(2): 272-7, 2008 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18488639

RESUMO

Self-report surveys and behavioral tasks indicate greater risk-taking behavior in adolescents as compared with adults. However, the underlying causes of these behavioral differences remain unclear. The present study examined the possibility that adolescents may be more susceptible to immediate positive and negative outcomes than adults. We compared the behavior of adolescents and adults on a modified version of the Balloon Analogue Risk Task (Lejuez et al., 2002). The task required that participants press a button to "inflate" a series of balloons on a computer screen. Balloons inflated until either the participant released the button ("saved" balloons) or the balloon "burst." Accumulated points increased as the duration of the buttonpress increased; however, simultaneously, the likelihood that the balloon would burst also increased. Adolescents inflated balloons to a larger size prior to saving them than adults did, suggesting relatively higher levels of risk taking, although the adolescents' behavior was not uniformly risk prone. Further, in comparison with adults, behavior in adolescents was more influenced by whether a balloon was saved or had burst on the preceding trial, suggesting that sensitivity to immediate consequences is one mechanism that underlies the observed difference in risk taking.


Assuntos
Comportamento do Adolescente/psicologia , Assunção de Riscos , Adolescente , Adulto , Demografia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Inquéritos e Questionários
12.
J Neurosci ; 27(40): 10734-41, 2007 Oct 03.
Artigo em Inglês | MEDLINE | ID: mdl-17913907

RESUMO

Early onset blindness leads to a dramatic alteration in the way the world is perceived, a change that is detectable in the organization of the brain. Several studies have confirmed that blindness leads to functional alterations in occipital cortices that normally serve visual functions. These reorganized brain regions respond to a variety of tasks and stimuli, but their specific functions are unclear. In sighted individuals, several studies have reported preparatory activity in retinotopic areas, which enhances perceptual sensitivity. "Baseline shifts," changes in activity associated with a cue predicting an upcoming event, provides a marker for attentional modulation. Here we demonstrate that, in early blind subjects, medial occipital areas produced significant blood oxygenation level-dependent (BOLD) responses to a cue signaling an auditory discrimination trial but not to a cue indicating a no-trial period. Furthermore, the amplitude of the BOLD response in the anterior calcarine sulcus of early blind subjects correlated with their discrimination performance on the auditory backward masking task. Preparatory BOLD responses also were present in auditory cortices, although they were more robust in blind than sighted control subjects. The pattern of response in visual areas is similar to preparatory effects observed during visual selective attention in sighted subjects and consistent with the hypothesis that the mechanisms implicated in visual attention continue to modulate occipital cortex in the early blind. A possible source of this top-down modulation may be the frontoparietal circuits that retain their connectivity with the reorganized occipital cortex and as a result influence processing of nonvisual stimuli in the blind.


Assuntos
Atenção/fisiologia , Percepção Auditiva/fisiologia , Cegueira/patologia , Julgamento/fisiologia , Lobo Occipital/fisiopatologia , Estimulação Acústica , Adulto , Cegueira/fisiopatologia , Mapeamento Encefálico , Sinais (Psicologia) , Feminino , Humanos , Processamento de Imagem Assistida por Computador , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Lobo Occipital/irrigação sanguínea , Oxigênio/sangue , Valor Preditivo dos Testes , Tempo de Reação , Reconhecimento Psicológico/fisiologia
13.
Neuropsychologia ; 45(10): 2307-21, 2007 Jun 11.
Artigo em Inglês | MEDLINE | ID: mdl-17397882

RESUMO

What happens in vision-related cortical areas when congenitally blind (CB) individuals orient attention to spatial locations? Previous neuroimaging of sighted individuals has found overlapping activation in a network of frontoparietal areas including frontal eye fields (FEF), during both overt (with eye movement) and covert (without eye movement) shifts of spatial attention. Since voluntary eye movement planning seems irrelevant in CB, their FEF neurons should be recruited for alternative functions if their attentional role in sighted individuals is only due to eye movement planning. Recent neuroimaging of the blind has also reported activation in medial occipital areas, normally associated with visual processing, during a diverse set of non-visual tasks, but their response to attentional shifts remains poorly understood. Here, we used event-related fMRI to explore FEF and medial occipital areas in CB individuals and sighted controls with eyes closed (SC) performing a covert attention orienting task with endogenous verbal cues and spatialized auditory targets. We found robust stimulus-locked FEF activation of all CB subjects, similar to and stronger than in SC, suggesting that FEF plays a role in endogenous orienting of covert spatial attention even in individuals in whom voluntary eye movements are irrelevant. We also found robust activation in bilateral medial occipital cortex in CB but not in SC subjects. The response decreased below baseline following endogenous verbal cues but increased following auditory targets, suggesting that the medial occipital area in CB does not directly engage during cued orienting of attention but may be recruited for processing of spatialized auditory targets.


Assuntos
Atenção/fisiologia , Cegueira/patologia , Cegueira/fisiopatologia , Lobo Occipital/fisiopatologia , Percepção Espacial/fisiologia , Campos Visuais/fisiologia , Estimulação Acústica/métodos , Adulto , Análise de Variância , Mapeamento Encefálico , Comportamento de Escolha/fisiologia , Movimentos Oculares/fisiologia , Feminino , Lateralidade Funcional/fisiologia , Humanos , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Lobo Occipital/irrigação sanguínea , Orientação/fisiologia , Oxigênio/sangue
14.
J Cogn Neurosci ; 19(2): 315-30, 2007 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-17280519

RESUMO

Visual deprivation early in life results in occipital cortical responsiveness across a broad range of perceptual and cognitive tasks. In the reorganized occipital cortex of early blind (EB) individuals, the relative lack of specificity for particular sensory stimuli and tasks suggests that attention effects may play a prominent role in these areas. We wished to establish whether occipital cortical areas in the EB were responsive to stimuli across sensory modalities (auditory, tactile) and whether these areas maintained or altered their activity as a function of selective attention. Using a three-stimulus oddball paradigm and event-related functional magnetic resonance imaging, auditory and tactile tasks presented separately demonstrated that several occipital regions of interest (ROIs) in the EB, but not sighted controls (SCs), responded to targets and task-irrelevant distracter stimuli of both modalities. When auditory and tactile stimuli were presented simultaneously with subjects alternating attention between sensory streams, only the calcarine sulcus continued to respond to stimuli in both modalities. In all other ROIs, responses to auditory targets were as large or larger than those observed in the auditory-alone condition, but responses to tactile targets were attenuated or abolished by the presence of unattended auditory stimuli. Both auditory and somatosensory cortices responded consistently to auditory and tactile targets, respectively. These results reveal mechanisms of orienting and selective attention within the visual cortex of EB individuals and suggest that mechanisms of enhancement and suppression interact asymmetrically on auditory and tactile streams during bimodal sensory presentation.


Assuntos
Atenção/fisiologia , Cegueira/patologia , Imageamento por Ressonância Magnética , Lobo Occipital/irrigação sanguínea , Lobo Occipital/fisiopatologia , Sensação/fisiologia , Adulto , Análise de Variância , Mapeamento Encefálico , Discriminação Psicológica , Feminino , Lateralidade Funcional , Humanos , Processamento de Imagem Assistida por Computador , Masculino , Pessoa de Meia-Idade , Oxigênio/sangue , Estimulação Física/métodos , Tempo de Reação , Limiar Sensorial/fisiologia
15.
Hear Res ; 211(1-2): 1-6, 2006 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-16256283

RESUMO

For blind individuals, audition provides critical information for interacting with the environment. Individuals blinded early in life (EB) typically show enhanced auditory abilities relative to sighted controls as measured by tasks requiring complex discrimination, attention and memory. In contrast, few deficits have been reported on tasks involving auditory sensory thresholds (e.g., Yates, J.T., Johnson, R.M., Starz, W.J., 1972. Loudness perception of the blind. Audiology 11(5), 368-376; Starlinger, I., Niemeyer, W., 1981. Do the blind hear better? Investigations on auditory processing in congenital or early acquired blindness. I. Peripheral functions. Audiology 20(6), 503-509). A study of gap detection stands at odds with this distinction [Muchnik, C., Efrati, M., Nemeth, E., Malin, M., Hildesheimer, M., 1991. Central auditory skills in blind and sighted subjects. Scand. Audiol. 20(1), 19-23]. In the current investigation we re-examined gap detection abilities in the EB using a single-interval, yes/no method. A group of younger sighted control individuals (SCy) was included in the analysis in addition to EB and sighted age matched control individuals (SCm) in order to examine the effect of age on gap detection performance. Estimates of gap detection thresholds for EB subjects were nearly identical to SCm subjects and slightly poorer relative to the SCy subjects. These results suggest some limits on the extent of auditory temporal advantages in the EB.


Assuntos
Limiar Auditivo/fisiologia , Cegueira/fisiopatologia , Adulto , Idade de Início , Percepção Auditiva/fisiologia , Cegueira/congênito , Estudos de Casos e Controles , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade
16.
Neuropsychologia ; 43(13): 1901-10, 2005.
Artigo em Inglês | MEDLINE | ID: mdl-15869766

RESUMO

Early-onset blindness (EB) produces measurable advantages in auditory perception, attention, memory and language. Neville and Bavelier [Neville, H. J., & Bavelier, D. (2001) Variability of developmental plasticity. In J. L. McClelland, R. S. Siegler (Eds.) Mechanisms of cognitive development: Behavioral andellon symposia on cognition (pp. 271-301)] hypothesized that faster temporal processing underlies many auditory compensatory effects in the blind. We tested this hypothesis by comparing early-onset blind individuals and sighted counterparts (SC) by assessing their rates of perceptual consolidation, the accurate perceptual representation of auditory stimuli. Firstly, we first tested both groups on a temporal-order judgment task (TOJ). EB subjects had significantly lower TOJ thresholds than the SC subjects. Secondly, we assessed perceptual consolidation speed using auditory backward masking tasks, taking into account individual TOJ thresholds. Discrimination performance was unaffected at all mask delays in the EB group while the SC subjects needed a mask delay of 160 ms to perform comparably. A backward masking task using single tone stimuli found no differences between the EB and SC groups any mask delay. A simultaneous masking task demonstrated that the mask effectively impaired discrimination in EB subjects at sensory stages. These results suggest that advantages in perceptual consolidation may reflect a mechanism responsible for the short response times and better performance reported in early blind individuals across a number of complex auditory tasks.


Assuntos
Limiar Auditivo/fisiologia , Cegueira/fisiopatologia , Discriminação Psicológica/fisiologia , Mascaramento Perceptivo/fisiologia , Privação Sensorial/fisiologia , Percepção do Tempo/fisiologia , Adaptação Fisiológica/fisiologia , Adulto , Feminino , Humanos , Julgamento/fisiologia , Masculino , Pessoa de Meia-Idade , Tempo de Reação/fisiologia , Valores de Referência
17.
Brain Res Cogn Brain Res ; 18(2): 162-71, 2004 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-14736575

RESUMO

Human speech carries both linguistic content and information about the speaker's identity and affect. While neuroimaging has been used extensively to study verbal memory, there has been little attention to the neural basis of memory for voices. Evidence from studies of aphasia and auditory agnosia suggests that voice memory may rely on anatomically distinct areas in the right temporal and parietal lobes regions, but there is little data on the broader neural systems involved in voice memory. The present study tested the hypothesis that the neural systems involved in voice memory are functionally distinct from the systems involved in word recognition and are primarily located in the right cerebral hemisphere. Subjects performed two-back tasks in which they were required to alternately remember the voices speaking (Voice condition), and the words they produced (Word condition). A tone memory condition was also included, as a non-speech comparison. The contrast between the Voice and Word conditions revealed greater Voice-related effects in left temporal, right frontal and right medial parietal areas, while the Word-related effects appeared in left frontal and bilateral parietal areas. These findings map out a partially right-lateralized fronto-parietal network associated with voice memory, which can be distinguished from predominantly left-hemisphere regions associated with verbal working memory. These results provide further evidence that distinct neural systems are associated with the carrier waves of speech and word identity.


Assuntos
Estimulação Acústica/métodos , Percepção Auditiva/fisiologia , Córtex Cerebral/fisiologia , Memória/fisiologia , Voz/fisiologia , Adulto , Feminino , Humanos , Imageamento por Ressonância Magnética/métodos , Masculino , Som , Fala/fisiologia
18.
Schizophr Res ; 53(3): 171-9, 2002 Jan 15.
Artigo em Inglês | MEDLINE | ID: mdl-11738530

RESUMO

We found previously that a subgroup of schizophrenic patients who passed screening tests of attentional competence showed memory deficits on word memory tasks, but were comparable with controls on tone memory tasks. To better understand the nature of language-specific memory deficits in this subgroup of patients, the present experiment was designed to bypass early perceptual processing of verbal material and determine if patients continue to show impaired performance on verbal memory tasks. Patients who passed the screening tests ('discriminator' patients; DSz) received four serial position tasks. In two, familiar sounds or line drawings were presented and subjects were required to remember the word associated with each stimulus item. In the other two, subjects received hard-to-label auditory and visual stimuli (birdsongs or snowflakes).DSz patients showed large memory deficits compared with controls when required to remember words associated with the familiar sounds or drawings, providing clear evidence of deficits in verbal memory processes independent of sensory processing of verbal stimuli. The interaction between diagnosis and labeling was highly significant, confirming that these patients have particular difficulty with verbal as opposed to non-verbal memory. This was particularly striking on the auditory tests where two patients out-performed all controls on the birdsong test, but were below all controls on the easy-to-label sounds test. The verbal memory tests were easier than the non-verbal memory tests for controls, thus deconfounding task difficulty and deficit specificity.


Assuntos
Transtornos Cognitivos/diagnóstico , Transtornos Cognitivos/etiologia , Transtornos da Linguagem/diagnóstico , Transtornos da Linguagem/etiologia , Esquizofrenia/complicações , Atenção , Humanos , Transtornos da Memória/diagnóstico , Transtornos da Memória/etiologia , Testes Neuropsicológicos , Índice de Gravidade de Doença , Acústica da Fala
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