Power Doppler ultrasound appearances of neonatal ischaemic brain injury.

Following neonatal ischaemic brain injury, irregular vessels increase in size owing to luxury perfusion. These may be demonstrated by conventional colour flow Doppler (CFD) imaging at the periphery of the infarcted area. We present a case in which power Doppler imaging (PDI) was performed in addition to CFD in a neonate with unexplained seizures and which proved more sensitive than CFD in demonstrating luxury perfusion. Ultrasound appearances were compared with those seen on cranial CT. PDI can be a useful adjunct to conventional CFD examination of the neonatal brain in cerebral infarction.

Emergency transjugular intrahepatic portosystemic shunt prior to liver transplantation.

Transjugular intrahepatic portosystemic shunt (TIPSS) is a new development in the management of severe variceal haemorrhage which has been established in adult patients. We have successfully adapted this technique for children and describe our initial experience in the case of a 9-year-old boy who presented with acute and chronic liver failure and uncontrollable life-threatening bleeding from oesophageal and gastric varices, despite intensive medical management including sclerotherapy. A 10-mm TIPSS was successfully placed with immediate reduction in portal pressure and cessation of variceal bleeding. The patient's condition stabilised sufficiently for him to undergo liver transplantation 2 days later, at which time the TIPSS was patent.

Reproducibility of bone ages when performed by radiology registrars: an audit of Tanner and Whitehouse II versus Greulich and Pyle methods.

This audit analysed the Tanner and Whitehouse II twenty bone (TW2) method of bone age assessment which was used in our department, and compared it with the Greulich and Pyle (GP) method. 50 previous bone ages were independently re-calculated by each of three registrars using both techniques, with the time taken to perform each assessment being recorded. For each method the interobserver variation was analysed in terms of the spread of results. The intraobserver variation in TW2 was determined by comparing the bone age originally reported with that subsequently calculated on the same film by the same registrar. The average spread of results was 0.74 years for TW2 method, and 0.96 years for the GP method and this difference is not statistically significant at the 5% level. The average intraobserver variation to TW2 was 0.33 years, but with 95% confidence limits of -0.87 to +1.53 years. The average time taken was 7.9 min for TW2 and 1.4 min for GP assessments. It was concluded that the GP method gave similar reproducibility and was faster than the TW2 method. Following clinical discussion the routine departmental bone age assessment method was changed from the TW2 to the GP method.

Measurement of tissue-bound amiodarone and its metabolites by computed tomography.

Amiodarone is strongly tissue-bound and serum levels are a poor guide to therapeutic efficacy. The electrocardiographic measure of the QT interval corrected for heart rate (QTc) is a better guide but is unhelpful in patients with bundle branch block or U-waves on the electrocardiogram. Myocardial amiodarone levels are the most accurate guide but are not easy to obtain. There is, however, a relationship between myocardial concentration and hepatic concentration of amiodarone and its metabolites. Since amiodarone contains iodine, and there is hepatic uptake, the increased hepatic attenuation from single slice computed tomography was compared with serum levels and the electrocardiographic QTc in 12 patients before and during amiodarone therapy. Hepatic attenuation increased by a mean value of 18.25 HU over a 12 month study period. This increase correlated well with increased QTc (r = 0.83) and with serum amiodarone levels (r = 0.89), but less well with serum desethyl amiodarone levels (r = 0.43). An iodine-containing phantom was used to construct a curve of attenuation against iodine concentration in mol/l. Thus an indirect measurement of amiodarone concentration in g/l wet weight of liver could be determined.