[Pymadine, a new type of non-depolarizing muscle-relaxant antagonist]. / Pymadine, un nou tip de antagonist al miorelaxantelor nedepolarizante.

The paper presents the author's experience in post-anesthetic decurarization with a new antagonist of competitive curare. Presented for the first time in 1970, 4-amino-pyridine was found o tbe a substance with a different mode of action than that of reversible inhibitors of cholinesterase, without parasympaticomimetic effects, and without untoward effects on the cardio-circulatory function. It also has a central analeptic effect. This is why the authors consider the new drug as a powerful means for reversing the competitive neuromuscular blockage.

[Use of preparation ST 1341 (althesin) in endovesical interventions]. / Prilozhenie na preparata ST 1341 (altezin) pri endovezikalni namesi.

The clinical course of monoanesthesia using ST 1341 (Altezin) preparation during endovesical manipulations and transurethral operative interventions in urology is outlined. The observations are done in a series of 31 patients with systematic study of a number of changes in respiration and hemodynamics, and of their mental and physical state prior to anesthesia and in the period just after awakening. The technique of intravenous Altezin administration does not require special anesthesiologic apparatus. The increase in arterial pressure in the course of anesthesia is accompanied by speeding up of the pulse rate, which should be mandatorily monitored in hypertension patients. Changes in respiration are minimal and transitory. The quick recovery of consciousness and the lack of distressing feelings warrant to consider Altezin monoanesthesia as one of the methods of choice in endovesical urological practice.