Assuntos
Síndrome Coronariana Aguda/diagnóstico por imagem , Cardiopatias/diagnóstico por imagem , Imagem Multimodal , Miosite/complicações , Adulto , Biópsia , Fármacos Cardiovasculares/uso terapêutico , Erros de Diagnóstico , Ecocardiografia Doppler em Cores , Feminino , Cardiopatias/tratamento farmacológico , Cardiopatias/etiologia , Cardiopatias/imunologia , Humanos , Imunossupressores/uso terapêutico , Imageamento por Ressonância Magnética , Miosite/diagnóstico , Miosite/tratamento farmacológico , Miosite/imunologia , Valor Preditivo dos Testes , Tomografia de Coerência ÓpticaRESUMO
Carney complex (CNC) is a rare autosomal dominant syndrome. Spotty skin pigmentation is the major clinical manifestation of CNC, followed by cardiac myxomas, benign tumors that usually present with features from the classical triad of obstructive cardiac, embolic and non-specific constitutional symptoms (NCS). NCS are caused by the overproduction of interleukin-6 (IL-6), a pro-inflammatory cytokine which mediates the induction of intercellular adhesion molecule 1 (ICAM-1) and promotes endothelial dysfunction and atherosclerosis. Thus, myxomas may be directly linked to an increased risk of atherosclerotic events. We report here a case of a 74-year-old woman with left atrial myxoma, skin pigmentary abnormalities, thyroid disorder and extensive atherosclerosis, with non-embolic occlusion of infrarenal abdominal aorta.