1.
Pharmazie
; 59(10): 814-5, 2004 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15544065
RESUMO
A dissolution test for oral veterinary pastes with ivermectin using the Ph. Eur. paddle apparatus was developed. Sink conditions were achieved with sodium lauryl sulphate in a concentration of 0.5% as dissolution medium. By means of HPLC fast degradation of ivermectin was observed in HCl 0.1 M solution. Rotation speed of the paddle at 75 rpm was appropriate as demonstrated in a study comparing two different products.