[Choice of antibacterial therapy with the use of a computerized consultation system]. / Vybor antibakterial'noi terapii s pomoshch'iu komp'iuternoi konsul'tativnoi sistemy.

The principle for a consulting system ensuring selection of a "theoretically optimal" antibiotic or antibacterial drug combination for the treatment of severe pyo-septic conditions in critically ill patients is described. The system is an addition to an automated case history, which ensures its efficacy. The algorithms are based on the analysis of the literary data and the results of many years of studying microorganisms in infectious foci.

[Peritonitis as aerobic-anaerobic infection]. / Peritonit kak aérobno-anaérobnaia infektsiia.

Results of clinico-microbiological examinations of 147 patients with peritonitis were analyzed. Strict anaerobic technique was used. It was established that in most cases peritonitis represented a mixed anaerobic aerobic infection (59.2%). The coliform microorganisms were dominating among aerobic ones, bacteroids-among anaerobic ones. The microbic character of inflammation (from abacterial to mixed forms) is dependent on the level (localization) of the inflammation source, duration of the inflammatory process. Mixed aerobic-anaerobic peritonitis has characteristic clinical features and requires an adequate antibacterial therapy.

[Possibilities of early roentgenologic diagnosis of surgical infection of soft tissues]. / Vozmozhnosti rannei rentgenodiagnostiki khirurgicheskoi infektsii miagkikh tkanei.

Findings of clinico-roentgenological examinations of 23 patients with an early stage of the surgical infection of soft tissues (necrotic cellulitis, fasciitis) developing without gas formation are described. Typical roentgenological symptoms were found. It was established that roentgenological symptoms often leave behind the wide clinical picture. It helps to begin timely curative measures.

[Head-space gas chromatographic analysis in the rapid diagnosis of anaerobic infections]. / Parofaznyi gazokhromatograficheskii analiz v ékspress-diagnostike anaérobnykh infektsii.

The comparison of the results obtained by the gas-chromatographic vapor-phase analysis and by the bacteriological analysis of exudate samples, taken from patients with intraperitoneal and intrapleural infections, has demonstrated high reliability of the chromatographic method. Despite the presence of some discrepancies between the results of the vapor-phase analysis and the bacteriological analysis due to the difficulties of the microbiological isolation of anaerobes and the specific features of their metabolism, the diagnostic value of the gas-chromatographic method has been confirmed.

[Theoretical basis of algorithmic management in the early period of surgical infection]. / Teoreticheskie osnovy algoritmicheskogo vedeniia rannego perioda khirurgicheskoi infektsii.

The classical theory of algorithms was used in the clinic of surgical infections. The principles described are necessary in acute cases for the selection of correct methods of treatment of severe suppurations in the period when results of some laboratory analyses are not available yet.

[Clinical picture, diagnosis and treatment of anaerobic abscess of the lung and pleurisy]. / Klinika, diagnostika i lechenie anaérobnykh abstsessov legkikh i plevrita.

Bacteriological examinations of 65 patients with abscesses of lungs and pleuritis have shown that non-sporulating anaerobic bacteria were isolated in 85% of purulent foci (without a concomitant aerobic microflora). Express-methods of diagnosis taking only 30-40 minutes give opportunities for early etiotropic therapy. Best results of treatment of anaerobic abscesses of lungs and pleuritis were obtained by a combination of sufficient drainage with the purposeful antianaerobic therapy.

[Features of the current stage in the study of surgical infection]. / Osobennosti sovremennogo étapa izucheniia khirurgicheskoi infektsii.

The article analyzes scientific problems for studying infection. Attention is paid to another role than that attributed by surgeons to staphylococci, gram-negative bacillus flora and anaerobes. A revision of the routinely used classification of surgical infections is shown to be necessary since their traditional division into purulent, putrifactive, anaerobic and specific ones is not up to the present state of science. It is noted that anaerobes take part in the appearance of 87% of postoperative complications and similar hospital infections.

[Nonclostridial anaerobic soft tissue infections]. / Neklostridial'nye anaérobnye infektsii miagkikh tkanei.

Fourteen cases of nonclostridial anaerobic infections of soft tissues caused by peptococci, peptostreptococci, bacteroids or their combinations with E. coli, Proteus, and Staphylococcus aureus were studied. They are characterized by a rapid spread of serous-suppurative inflammation and the causative agents in loose fibrous connective tissue of subcutaneous adipose tissue (cellutitis), surface fascia (fasciitis), or skeletal muscles (myositis). Dissolution of intercellular structures of the connective tissue, extensive necroses, mild leukocyte reaction, and a wide peripheral zone of toxic edema are observed in the focus of inflammation. This is due to a high toxicity and enzymatic activity of the causative agents. Gas formation is observed when anaerobes are combined with E. coli.

[Clinico-diagnostic value of the anaerobic method of study of the purulent foci in surgical patients]. / Kliniko-diagnosticheskoe znachenie anaérobnoi tekhniki issledovaniia gnoinykh ochagov u khirurgicheskikh bol'nykh.

The paper presents data of studying pyo-inflammatory diseases in 168 surgical patients. A large group of bacteria referred to strict anaerobes is shown to take part in pathogenesis of suppuration. These pathogenic agents are related with the appearance of 87% of hospital and endogenous infections and with the appearance of 39% of infections of the traumatic and other exogenous etiology. The aerobic infections made only 38% of the total amount of the patients examined, anaerobic infections made 16%. In the rest 46% of patients the diseases were of the mixed anaerobic-aerobic etiology.