RESUMO
The study investigated the possibility of influencing immunotoxic effects of Cd through ascorbic acid. Guinea pigs with high and low intake of ascorbic acid were perorally exposed to cadmium chloride (1 mg Cd/animal/day). The daily vitamin C intake was 2 and 100 mg per animal, respectively. Phagocytic activity of polymorphonuclear leucocytes and monocytes as well as the percentage of active and total T lymphocytes in peripheral blood of animals were evaluated. Five- and 12-week experiments showed a mutual potentiation of negative effects of Cd on the immune system by suboptimal intake of ascorbic acid. Toxic effects of Cd on the immune system can be reduced by a sufficient intake of vitamin C.
Assuntos
Ácido Ascórbico/farmacologia , Intoxicação por Cádmio/prevenção & controle , Cádmio/toxicidade , Imunidade Celular/efeitos dos fármacos , Animais , Ácido Ascórbico/administração & dosagem , Ácido Ascórbico/uso terapêutico , Deficiência de Ácido Ascórbico/imunologia , Peso Corporal/efeitos dos fármacos , Interações Medicamentosas , Exposição Ambiental , Cobaias , Fígado/efeitos dos fármacos , Ativação Linfocitária/efeitos dos fármacos , Masculino , Monócitos/efeitos dos fármacos , Monócitos/imunologia , Neutrófilos/efeitos dos fármacos , Neutrófilos/imunologia , Tamanho do Órgão/efeitos dos fármacos , Fagocitose/efeitos dos fármacos , Formação de Roseta , Baço/efeitos dos fármacos , Linfócitos T/efeitos dos fármacos , Linfócitos T/imunologiaRESUMO
Immune functions were examined in male rats following 28 day oral administration of formaldehyde by gastric tube at dose levels of 0, 20, 40, and 80 mg/kg. Routine parameters examined included hematology, clinical chemistry, and body, thymus, kidney, and liver weights. In addition, cellularity of spleen and lymph nodes, histology of spleen, thymus, lymph nodes, liver kidney, small and large intestines, and histochemistry of spleen and lymph nodes were evaluated. Immune parameters evaluated included serum hemagglutinin antibody response; antibody plaque forming cell response to sheep erythrocytes (lymphocyte-dependent antigen); microbicidal activity of Candida albicans; and phagocytic activity by adhesion of microspheric hydrophilic synthetic particles to leukocyte cell membrane. Body weights were slightly decreased at high dose level (80 mg/kg). The difference was significant when compared to the controls. The lymph node weights were significantly increased in rats receiving formaldehyde. The cellularity of lymphoid organs was not influenced after 28 day exposure to formaldehyde.
