RESUMO
India is expected to witness rapid growth in electricity use over the next two decades. Here, we introduce a custom regression model to project electricity consumption in India over the coming decades, which includes a bottom-up estimate of electricity consumption for two major growth drivers, air conditioning, and vehicle electrification. The model projections are available at a customizable level of spatial aggregation at an hourly temporal resolution, which makes them useful as inputs to long-term electricity infrastructure planning studies. The approach is used to develop electricity consumption data sets spanning various technology adoption and growth scenarios up to the year 2050 in five-year increments. The aim of the data is to provide a range of scenarios for India's demand growth given new technology adoption. With long-term hourly demand projections serving as an essential input for electricity infrastructure modeling, this data publication enables further work on energy efficiency, generation, and transmission expansion planning for a fast-growing and increasingly important region from a global climate mitigation perspective.
RESUMO
Multigram drug depot systems for extended drug release could transform our capacity to effectively treat patients across a myriad of diseases. For example, tuberculosis (TB) requires multimonth courses of daily multigram doses for treatment. To address the challenge of prolonged dosing for regimens requiring multigram drug dosing, we developed a gastric resident system delivered through the nasogastric route that was capable of safely encapsulating and releasing grams of antibiotics over a period of weeks. Initial preclinical safety and drug release were demonstrated in a swine model with a panel of TB antibiotics. We anticipate multiple applications in the field of infectious diseases, as well as for other indications where multigram depots could impart meaningful benefits to patients, helping maximize adherence to their medication.
